F. W. Nicholas
A5053230157- Genetic and phenotypic traits in livestock
- Genetic Mapping and Diversity in Plants and Animals
- Animal Genetics and Reproduction
- Cancer-related molecular mechanisms research
- Genomics and Phylogenetic Studies
- Chromosomal and Genetic Variations
- Human-Animal Interaction Studies
- Veterinary Orthopedics and Neurology
- Genetic diversity and population structure
- Glycosylation and Glycoproteins Research
- Animal Disease Management and Epidemiology
- Microbial infections and disease research
- Hip disorders and treatments
- Fish Ecology and Management Studies
- Helminth infection and control
- Galectins and Cancer Biology
- Veterinary Equine Medical Research
- Genetics and Plant Breeding
- Insect and Pesticide Research
- Vector-Borne Animal Diseases
- Congenital heart defects research
- Molecular Biology Techniques and Applications
- T-cell and Retrovirus Studies
- Australian Indigenous Culture and History
- Wheat and Barley Genetics and Pathology
The University of Sydney
2015-2025
University of Kansas
2013
University of Kansas Medical Center
2013
The University of Kansas Cancer Center
2013
Centennial College
2009
Sydney Hospital
1980
To understand the biology and evolution of ruminants, cattle genome was sequenced to about sevenfold coverage. The contains a minimum 22,000 genes, with core set 14,345 orthologs shared among seven mammalian species which 1217 are absent or undetected in noneutherian (marsupial monotreme) genomes. Cattle-specific evolutionary breakpoint regions chromosomes have higher density segmental duplications, enrichment repetitive elements, species-specific variations genes associated lactation immune...
Sheep (Ovis aries) are a major source of meat, milk, and fiber in the form wool represent distinct class animals that have specialized digestive organ, rumen, carries out initial digestion plant material. We developed analyzed high-quality reference sheep genome transcriptomes from 40 different tissues. identified highly expressed genes encoding keratin cross-linking proteins associated with rumen evolution. also involved lipid metabolism had been amplified and/or altered tissue expression...
The genetic structure of sheep reflects their domestication and subsequent formation into discrete breeds. Understanding is essential for achieving improvement through genome-wide association studies, genomic selection the dissection quantitative traits. After identifying first set SNP sheep, we report on levels variability both within between a diverse sample ovine populations. Then, using cluster analysis partitioning variation, demonstrate are characterised by weak phylogeographic...
ABSTRACT Possibilities for increased rates of genetic change in dairy cattle through embryo transfer and splitting are examined, using the multiple ovulation systems previously proposed. These involve from 1-year-old females (juvenile scheme, generation interval 1·8 years) after 1 lactation (adult 3·7 years), with use males at similar ages. Though selection is less accurate than conventional progeny testing, annual rate improvement can be increased, even doubled. If number transfers...
The international Dog10K project aims to sequence and analyze several thousand canine genomes. Incorporating 20 × data from 1987 individuals, including 1611 dogs (321 breeds), 309 village dogs, 63 wolves, four coyotes, we identify genomic variation across the canid family, setting stage for detailed studies of domestication, behavior, morphology, disease susceptibility, genome architecture function.
The extent of linkage disequilibrium (LD) within a population determines the number markers that will be required for successful association mapping and marker-assisted selection. Most studies on LD in cattle reported to date are based microsatellite or small numbers single nucleotide polymorphisms (SNPs) covering one only few chromosomes. This is first comprehensive study by analyzing data 1,546 Holstein-Friesian bulls genotyped 15,036 SNP all regions autosomes. Furthermore, most have used...
Abstract Background We present the genome sequence of tammar wallaby, Macropus eugenii , which is a member kangaroo family and first representative iconic hopping mammals that symbolize Australia to be sequenced. The has many unusual biological characteristics, including longest period embryonic diapause any mammal, extremely synchronized seasonal breeding prolonged sophisticated lactation within well-defined pouch. Like other marsupials, it gives birth highly altricial young, small number...
Abstract There are thousands of distinct disease entities and concepts, each which known by different sometimes contradictory names. The lack a unified system for managing these poses major challenge both machines humans that need to harmonize information better predict causes treatments disease. Mondo Disease Ontology is an open, community-driven ontology integrates key medical biomedical terminologies, supporting data integration improve diagnosis, treatment, translational research....
Online Mendelian Inheritance in Animals (OMIA is a freely available information resource, which includes for
Is it possible to construct an accurate and detailed subgene-level map of a genome using bacterial artificial chromosome (BAC) end sequences, sparse marker map, the sequences other genomes? A sheep BAC library, CHORI-243, was constructed were determined mapped with high sensitivity low specificity onto frameworks human, dog, cow genomes. To maximize coverage, coordinates all sequence hits dog genomes also converted equivalent human coordinates. The 84,624 BACs (about 5.4-fold coverage)...
Abstract Analysis of data on 1000 Holstein–Friesian bulls genotyped for 15,036 single-nucleotide polymorphisms (SNPs) has enabled genomewide identification haplotype blocks and tag SNPs. A final subset 9195 SNPs in Hardy–Weinberg equilibrium mapped autosomes the bovine sequence assembly (release Btau 3.1) was used this study. The average intermarker spacing 251.8 kb. minor allele frequency (MAF) 0.29 (0.05–0.5). Following recent precedents human HapMap studies, a block defined where 95%...
Cattle are important agriculturally and relevant as a model organism. Previously described genetic radiation hybrid (RH) maps of the bovine genome have been used to identify genomic regions genes affecting specific traits. Application these influential polymorphisms will be enhanced by integration with each other bacterial artificial chromosome (BAC) libraries. The BAC libraries clone essential for clone-by-clone/whole-genome shotgun sequencing approach taken project. A map was constructed...
Abstract This paper reviews the history of establishment dog breeds, summarizes current health and resultant welfare problems makes some positive suggestions for their resolution. Some breed standards selection practices run counter to interests dogs, extent that breeds are characterized by traits may be difficult defend on grounds. Meanwhile, little pressure seems exerted would improve animal produce dogs better suited modern society. Unfortunately, incidence certain inherited defects in is...
Online Mendelian Inheritance in Animals (OMIA) provides up-to-date information on inherited disorders and other familial traits non-laboratory animals. It is freely available online at http://www.angis.org.au/omia. With a strong emphasis comparative biology, OMIA modelled on, reciprocally hyperlinked with, Man (OMIM). comprehensive catalog of animal models human disorders, also access to potential homologues Because its whole structure based it phenotypic format that complementary all the...
SUMMARY The analysis and design of experiments to estimate heritability when data are available on both parents offspring discussed. It is shown that there a substantial positive sampling correlation between the regression mid-parent covariance full sibs estimated from same data, in hierarchical structure half has negative with dam sire. efficiency alternative estimators by sib covariance, pooled based these maximum likelihood (ML) compared. ML estimator does not reduce variance...
SUMMARY It is widely acknowledged that genetic drift an important source of variation in response to artificial directional selection. How large should a selection line be order reduce the effect acceptably low level? This paper investigates two criteria can used answer this question relation short-term The first criterion coefficient response, and second chance success, where successful programme one which observed greater than certain proportion, β, expected response. For simple mass with...