A5081367108- Animal Genetics and Reproduction
- Infant Nutrition and Health
- Protein Hydrolysis and Bioactive Peptides
- Milk Quality and Mastitis in Dairy Cows
- Digestive system and related health
- Genetic and phenotypic traits in livestock
- Antimicrobial Peptides and Activities
- Neonatal Respiratory Health Research
- Marine animal studies overview
- Proteins in Food Systems
- Xenotransplantation and immune response
- Growth Hormone and Insulin-like Growth Factors
- Biomedical Text Mining and Ontologies
- Bone and Dental Protein Studies
- Immune Response and Inflammation
- Bat Biology and Ecology Studies
- Nutrition, Genetics, and Disease
- Cancer Cells and Metastasis
- Wildlife Ecology and Conservation
- Congenital heart defects research
- Birth, Development, and Health
- Fatty Acid Research and Health
- Probiotics and Fermented Foods
- RNA Interference and Gene Delivery
- Cancer Risks and Factors
Monash University
2014-2023
The University of Melbourne
2006-2019
Deakin University
2009-2018
Dairy Australia (Australia)
2006
Agriculture Victoria
1997-2003
Commonwealth Scientific and Industrial Research Organisation
1987-1995
Women's & Children's Health Research Institute
1995
Cooperative Research Centre for Tissue Growth and Repair
1995
Weatherford College
1991
National Institute of Diabetes and Digestive and Kidney Diseases
1981-1988
We present a draft genome sequence of the platypus, Ornithorhynchus anatinus. This monotreme exhibits fascinating combination reptilian and mammalian characters. For example, platypuses have coat fur adapted to an aquatic lifestyle; platypus females lactate, yet lay eggs; males are equipped with venom similar that reptiles. Analysis first aligned these features genetic innovations. find reptile proteins been co-opted independently from same gene families; milk protein genes conserved despite...
Abstract Background We present the genome sequence of tammar wallaby, Macropus eugenii , which is a member kangaroo family and first representative iconic hopping mammals that symbolize Australia to be sequenced. The has many unusual biological characteristics, including longest period embryonic diapause any mammal, extremely synchronized seasonal breeding prolonged sophisticated lactation within well-defined pouch. Like other marsupials, it gives birth highly altricial young, small number...
The mammary gland represents a unique tissue to study organogenesis as it predominantly develops in the post-natal animal and undergoes dramatic morphogenetic changes during puberty reproductive cycle. physiological function of is produce milk sustain newborn. Here we view lactating through three-dimensional confocal imaging intact tissue. We observed that majority secretory alveolar cells are binucleated. These first arise very late pregnancy due failure cytokinesis larger than...
In the presence of cortisol and prolactin, insulin at concentrations as low 1 ng/ml significantly stimulates casein synthesis in mammary explants from midpregnant mice; maximal occurs 10 ng/ml. However, absence insulin, no detectable immunoprecipitable is produced. Insulin also supports enhanced accumulation mRNA prolactin; neither epidermal growth factor nor somatomedin C has this effect. These inductive actions are not secondary to a general maintenance effect on epithelial cell; factor,...
Lactation is a key aspect of mammalian evolution for adaptation various reproductive strategies along different lineages. Marsupials, such as tammar wallaby, adopted short gestation and relatively long lactation cycle, the newborn immature at birth significant development occurs postnatally during lactation. Continuous changes milk composition may contribute to immune protection pouch young. Here, in order address putative contribution newly identified secretory miRNA these processes, high...
Desired wettability has been achieved on highly hydrophobic boron nitride nanotube (BNNT) films using nitrogen/hydrogen (N2/H2) gas plasma treatments under controlled input energies and modes. Both hydrophilicity (contact angle (CA) ∼60°) superhydrophilicity (CA < 5°) are demonstrated BNNT with little change of the surface morphology or structure individual BNNTs. The combination continuous wave pulse mode (CW+P) shows more effective modification introduces amine functional groups than (CW)...
Specific changes in milk composition during lactation the tammar wallaby (Macropus eugenii) were correlated with ages of developing pouch young (PY). The present experiment was designed to test hypothesis that sucking pattern PY determines course mammary development wallaby. To this hypothesis, groups 60-day-old fostered repeatedly onto one group host mothers so a constant stimulus on gland maintained for 56 days allow lactational stage progress 42 ahead age young. Analysis and control...
The mammary gland undergoes a sophisticated programme of developmental changes during pregnancy/lactation. However, little is known about processes involving initiation apoptosis at involution following weaning. We used fur seals as models to study the molecular process these animals display unique phenotype. Fur have long lactation periods whereby mothers cycle between secreting copious quantities milk for 2 3 days suckling pups on land, with trips sea alone forage up 23 which time glands...
Monotremes are the only oviparous mammals and exhibit a fascinating combination of reptilian mammalian characters. They represent component synapsidal reproduction by laying shelled eggs which incubated outside mother's body. This is accompanied prototherian lactation process, marking them as representatives early mammals. The extant monotremes platypus, short- long- beaked echidnas, their distributions limited to Australia New Guinea. Apart for short weaning period, milk sole source...
Both male and female pigeons have the ability to produce a nutrient solution in their crop for nourishment of young. The production has been likened lactation mammals, hence product called pigeon 'milk'. It shown that 'milk' is essential growth development squab, without it they fail thrive. Studies investigated nutritional value but very little else known about what or how produced. This study aimed gain insight into process by studying gene expression 'lactating' crop.Macroscopic...
The pigeon crop is specially adapted to produce milk that fed newly hatched young. process of production begins when the germinal cell layer rapidly proliferates in response prolactin, which results a mass epithelial cells are sloughed from and regurgitated We proposed evolution built upon ability avian keratinocytes accumulate intracellular neutral lipids during cornification epidermis. However, this has not been characterised.We identified epidermal differentiation complex draft genome...
Nanomaterials are rich in potential, particularly for the formation of scaffolds that mimic landscape host environment cell. This niche arises from spatial organization a series biochemical and biomechanical signals. Self-assembling peptides have emerged as an important tool development functional (bio-)nanomaterials; these simple, easily synthesized subunits form structures which present properties larger, more complex systems. Scaffolds based upon nanofibrous matrices promising materials...
Secretion of whey acidic protein (WAP) in milk throughout lactation has previously been reported for a limited number species, including the mouse, rat, rabbit, camel, and pig. We report here isolation WAP from marsupial, tammar wallaby (Macropus eugenii). Tammar (tWAP) was isolated by reverse-phase HPLC migrates SDS-polyacrylamide gel electrophoresis at 29.9 kDa. tWAP is major protein, but contrast to eutherians, secretion asynchronous occurs only approximately days 130 through 240...
Lactation is an important aspect of mammalian biology and, amongst mammals, marsupials show one the most complex lactation cycles. Marsupials, such as tammar wallaby (Macropus eugenii) give birth to a relatively immature newborn and progressive changes in milk composition production regulate early stage development young. In order investigate gene expression marsupial mammary gland during lactation, comprehensive set cDNA libraries was derived from lactating tissues throughout cycle wallaby....