A5021873473- Cutaneous Melanoma Detection and Management
- Animal Genetics and Reproduction
- Melanoma and MAPK Pathways
- Infant Nutrition and Health
- Marine animal studies overview
- Immunotherapy and Immune Responses
- Cutaneous lymphoproliferative disorders research
- Cancer Cells and Metastasis
- Clusterin in disease pathology
- Cancer Mechanisms and Therapy
- Cell Adhesion Molecules Research
- Computational Drug Discovery Methods
- Cancer therapeutics and mechanisms
- Mesenchymal stem cell research
- Bat Biology and Ecology Studies
- Pharmacological Receptor Mechanisms and Effects
- Digital Imaging for Blood Diseases
- Gene expression and cancer classification
- Milk Quality and Mastitis in Dairy Cows
- Clinical practice guidelines implementation
- Immune Response and Inflammation
- Marine Bivalve and Aquaculture Studies
- Aquaculture disease management and microbiota
- Cancer, Lipids, and Metabolism
- Cancer Immunotherapy and Biomarkers
Peter MacCallum Cancer Centre
2015-2024
The University of Melbourne
2006-2023
Melanoma Institute Australia
2022
A wide variety of animal models have been used to study human breast cancer. Murine, feline and canine mammary tumor cell lines studied for several decades shown numerous aspects in common with It is clear that new comparative approaches cancer etiology are likely be productive. continuous line carcinoma cells (WalBC) was established from a primary spontaneously arose female tammar wallaby (Macropus eugenii). The 1.5 cm3 although large, did not appear invade the stroma lacked vimentin...
Summary BRAF mutations at codons L597 and K601 occur uncommonly in melanoma. Clinical pathological associations of these were investigated a cohort 1119 patients with known mutation status. A was identified 435 patients; Mutations the K601E seen 3.4 3.2% these, respectively. melanomas tended to male patients, median age 58 yr, generally found on trunk (64%) associated chronically sun‐damaged ( CSD ) skin. occurred older (median 66 yr), but skin (extremities or head neck location – 73.3%, P =...
The majority of melanomas are thin lesions with an excellent prognosis; however, significant tumor heterogeneity exists, and a small percentage patients early-stage disease may progress to metastatic recurrence. This study aimed assess whether prognostic factors previously shown be in predicting stage I II melanoma recurrence were consistent large prospectively collected patient cohort, identify novel associated early inform follow-up protocols. There 1029 included the analysis, whom 123...
Pre-clinical and clinical studies propose that statins may have chemopreventive effects against cancer, suggesting their possible roles as adjunctive therapies for melanoma. To investigate the association between regular statin use disease recurrence in patients with resected Stage I-III We conducted a retrospective analysis of enrolled multi-centre Melanoma Research Victoria cohort histologically confirmed, American Joint Committee on Cancer cutaneous Patients uveal melanoma, melanoma...
Abstract Background Combined expression of the autophagy-regulatory protein AMBRA1 (activating molecule in Beclin1-regulated autophagy) and terminal differentiation marker loricrin peritumoral epidermis stage I melanomas can identify tumour subsets at low risk metastasis. Objectives To validate combined (AMBLor) as a prognostic biomarker able to both II recurrence. Methods Automated immunohistochemistry was used analyse geographically distinct discovery (n = 540) validation 300) cohorts...
Hormonal stimulation of mammary explants mimics many the biochemical changes observed during lactogenesis. Previous studies using eutherian species conclude that require addition exogenous macromolecules to remain hormone responsive in culture. The present study examines survival from wallaby and mouse milk protein gene expression as a functional marker lactation cell viability. Mammary pregnant tammars mice showed was significantly elevated after 3 days culture with lactogenic hormones....
Abstract Background Clinical quality registries aim to identify significant variations in care and provide anonymised feedback institutions improve patient outcomes. Thirty‐six Australian organisations with an interest melanoma, raised funds through three consecutive Melanoma Marches, organised by Institute Australia, create a national Outcomes Registry (MelCOR). This study aimed formally develop valid clinical indicators for the diagnosis early management of cutaneous melanoma as important...
9573 Background: Cutaneous melanoma incidence continue to increase, with a particular increase in the number of patients diagnosed thin, < 1mm tumours reduced probability recurrence-free survival. The inability current AJCC staging criteria identify genuinely low risk subsets stage I/II thus emphasises acute need for credible prognostic biomarkers stratify patient follow-up based on personalised risk. combined immunohistochemical (IHC) expression AMBRA1 and Loricrin (AMBLor) epidermis...