A5003742829- Genomics and Phylogenetic Studies
- Human-Animal Interaction Studies
- Virus-based gene therapy research
- Animal Genetics and Reproduction
- Veterinary Oncology Research
- Chromosomal and Genetic Variations
- Cancer Research and Treatments
- Cancer-related molecular mechanisms research
- Genetic Mapping and Diversity in Plants and Animals
- Genetic and phenotypic traits in livestock
- Infectious Diseases and Mycology
- Genomic variations and chromosomal abnormalities
- Molecular Biology Techniques and Applications
- Epigenetics and DNA Methylation
- Wildlife Ecology and Conservation
- RNA modifications and cancer
- Wnt/β-catenin signaling in development and cancer
- Skin and Cellular Biology Research
- RNA Research and Splicing
- Genetic diversity and population structure
- Biochemical Analysis and Sensing Techniques
- dental development and anomalies
- Forensic and Genetic Research
- Olfactory and Sensory Function Studies
- Neurological diseases and metabolism
Institut de génétique et de développement de Rennes
2015-2024
Université de Rennes
2013-2023
Centre National de la Recherche Scientifique
2014-2023
Structure Fédérative de Recherche en Biologie et Santé de Rennes
2014-2020
Inserm
2017
University of Pennsylvania
2009
University of California, San Francisco
2009
Laboratoire de Génétique Cellulaire
2009
Texas A&M University
2005
Science Applications International Corporation (United States)
2005
The genome organizations of eight phylogenetically distinct species from five mammalian orders were compared in order to address fundamental questions relating chromosomal evolution. Rates chromosome evolution within found increase since the Cretaceous-Tertiary boundary. Nearly 20% breakpoint regions reused during evolution; these reuse sites are also enriched for centromeres. Analysis gene content and around evolutionary revealed increased density relative genome-wide average. We that...
A dogged investigation of domestication The history how wolves became our pampered pooches today has remained controversial. Frantz et al. describe high-coverage sequencing the genome an Irish dog from Bronze Age as well ancient mitochondrial DNA sequences. Comparing dogs to a modern worldwide panel shows old, deep split between East Asian and Western Eurasian dogs. Thus, were domesticated two separate wolf populations on either side Old World. Science , this issue p. 1228
Whole transcriptome sequencing (RNA-seq) has become a standard for cataloguing and monitoring RNA populations. One of the main bottlenecks, however, is to correctly identify different classes RNAs among plethora reconstructed transcripts, particularly those that will be translated (mRNAs) from class long non-coding (lncRNAs). Here, we present FEELnc (FlExible Extraction LncRNAs), an alignment-free program accurately annotates lncRNAs based on Random Forest model trained with general features...
The extraordinary phenotypic diversity of dog breeds has been sculpted by a unique population history accompanied selection for novel and desirable traits. Here we perform comprehensive analysis using multiple test statistics to identify regions under in 509 dogs from 46 diverse newly developed high-density genotyping array consisting >170,000 evenly spaced SNPs. We first 44 genomic exhibiting extreme differentiation across breeds. Genetic variation these correlates with several traits that...
The international Dog10K project aims to sequence and analyze several thousand canine genomes. Incorporating 20 × data from 1987 individuals, including 1611 dogs (321 breeds), 309 village dogs, 63 wolves, four coyotes, we identify genomic variation across the canid family, setting stage for detailed studies of domestication, behavior, morphology, disease susceptibility, genome architecture function.
We present here the first fully integrated, comprehensive map of canine genome, incorporating detailed cytogenetic, radiation hybrid (RH), and meiotic information. have mapped a collection 266 chromosome-specific cosmid clones, each containing microsatellite marker, to all 38 autosomes by fluorescence in situ hybridization (FISH). A 1500-marker RH map, comprising 1078 microsatellites, 320 dog gene markers, 102 has been constructed using RHDF5000-2 whole-genome panel. Meiotic linkage analysis...
The purebred dog population consists of >300 partially inbred genetic isolates or breeds. Restriction gene flow between breeds, together with strong selection for traits, has led to the establishment a unique resource dissecting basis simple and complex mammalian traits. Toward this end, we present comprehensive radiation hybrid map canine genome composed 3,270 markers including 1,596 microsatellite-based markers, 900 cloned sequences ESTs, 668 canine-specific bacterial artificial...
Abstract Background The Nile tilapia ( Oreochromis niloticus ) is the second most farmed fish species worldwide. It also an important model for studies of physiology, particularly because its broad tolerance to array environments. a good study evolutionary mechanisms in vertebrates, close relationship haplochromine cichlids, which have undergone rapid speciation East Africa. existing genomic resources include genetic map, BAC end sequences and ESTs, but comparative genome analysis maps...
ABSTRACT Dogs are the most phenotypically diverse mammalian species, and they possess more known heritable disorders than any other non-human mammal. Efforts to catalog characterize genetic variation across well-chosen populations of canines necessary advance our understanding their evolutionary history architecture. To date, no organized effort has been undertaken sequence world's canid populations. The Dog10K Consortium (http://www.dog10kgenomes.org) is an international collaboration...
Mutations in the MTM1 gene encoding myotubularin cause X-linked myotubular myopathy (XLMTM), a well-defined subtype of human centronuclear myopathy. Seven male Labrador Retrievers, age 14–26 wk, were clinically evaluated for generalized weakness and muscle atrophy. Muscle biopsies showed variability fiber size, centrally placed nuclei resembling fetal myotubes, subsarcolemmal ringed central dense areas highlighted with mitochondrial specific reactions. Ultrastructural studies confirmed...
Copy number variants (CNVs) account for substantial variation between genomes and are a major source of normal pathogenic phenotypic differences. The dog is an ideal model to investigate mutational mechanisms that generate CNVs as its genome lacks functional ortholog the PRDM9 gene implicated in recombination CNV formation humans. Here we comprehensively assay using high-density array comparative genomic hybridization 50 dogs from 17 breeds 3 gray wolves. We use stringent new method identify...
Summary The genome of the filamentous brown alga Ectocarpus was first to be completely sequenced from within algal group and has served as a key reference both for this lineage stramenopiles. We present complete structural functional reannotation genome. large‐scale assembly significantly improved genome‐wide gene re‐annotation using extensive RNA ‐seq data structure 11 108 existing protein‐coding genes added 2030 new loci. A analysis splicing isoforms identified an average 1.6 transcripts...
Extant dog and wolf DNA indicates that domestication was accompanied by the selection of a series duplications on Amy2B gene coding for pancreatic amylase. In this study, we used palaeogenetic approach to investigate timing expansion in ancient populations Western Eastern Europe Southwest Asia. Quantitative polymerase chain reaction estimate copy numbers 13 samples, dated between 15 000 4000 years before present (cal. BP). This evidenced an increase copies dogs from as early 7th millennium...
Significance Advancements in long-read DNA sequencing technologies provide more comprehensive views of genomes. We used sequences to assemble a Great Dane dog genome that provides several improvements over the existing reference derived from Boxer. Assembly comparisons revealed gaps Boxer assembly often occur at beginning protein-coding genes and have high-GC content, which likely reflects limitations previous resolving GC-rich sequences. Dimorphic LINE-1 SINEC retrotransposons represent...
The 156 breeds of dog recognized by the American Kennel Club offer a unique opportunity to map genes important in genetic variation. Each breed features defining constellation morphological and behavioral traits, often generated deliberate crossing closely related individuals, leading high rate disease many breeds. Understanding basis both phenotypic variation susceptibility provides new ways which dissect genetics human health biology. To facilitate mapping cloning efforts, we have...
Neuronal ceroid lipofuscinoses (NCLs) represent the most common group of inherited progressive encephalopathies in children. They are characterized by loss vision, mental and motor deterioration, epileptic seizures, premature death. Rare adult forms NCL with late onset known as Kufs’ disease. Loci underlying these remain unknown due to small number patients genetic heterogeneity. Here we confirm that a late-onset form recessively segregates US French pedigrees American Staffordshire Terrier...
Near Eastern Neolithic farmers introduced several species of domestic plants and animals as they dispersed into Europe. Dogs were the only present in both Europe East prior to Neolithic. Here, we assessed whether early dogs possessed a unique mitochondrial lineage that differentiated them from Mesolithic European populations. We then analysed DNA sequences 99 ancient spanning Upper Palaeolithic Bronze Age assess if incoming brought with them, or instead primarily adopted indigenous after...