A5080727812- Genetic and phenotypic traits in livestock
- Genetic Mapping and Diversity in Plants and Animals
- Cancer-related molecular mechanisms research
- Animal Genetics and Reproduction
- Molecular Biology Techniques and Applications
- RNA and protein synthesis mechanisms
- Adipose Tissue and Metabolism
- Biochemical Analysis and Sensing Techniques
- MicroRNA in disease regulation
- Genomics and Phylogenetic Studies
- RNA Research and Splicing
- Human-Animal Interaction Studies
- Helminth infection and control
- Animal Nutrition and Physiology
- Chromosomal and Genetic Variations
- Cardiovascular Conditions and Treatments
- Veterinary Equine Medical Research
- Neurological diseases and metabolism
- Indigenous Studies and Ecology
- Microbial infections and disease research
- Diet and metabolism studies
- Parasites and Host Interactions
- Escherichia coli research studies
- Meat and Animal Product Quality
- Marine animal studies overview
University of Copenhagen
2016-2025
University of Teramo
2023
Texas A&M University
2023
University of Oslo
2019
IT University of Copenhagen
2016
Lantmännen
2013
Swedish University of Agricultural Sciences
1993-2011
Ludwig-Maximilians-Universität München
2011
University of Liverpool
2011
École Nationale Vétérinaire d'Alfort
2011
For 10,000 years pigs and humans have shared a close complex relationship. From domestication to modern breeding practices, shaped the genomes of domestic pigs. Here we present assembly analysis genome sequence female Duroc pig (Sus scrofa) comparison with wild from Europe Asia. Wild emerged in South East Asia subsequently spread across Eurasia. Our results reveal deep phylogenetic split between European Asian boars ∼1 million ago, selective sweep indicates selection on genes involved RNA...
The European wild boar was crossed with the domesticated Large White pig to genetically dissect phenotypic differences between these populations for growth and fat deposition. most important effects were clustered on chromosome 4, a single region accounting large part of breed difference in rate, fatness, length small intestine. study is an advance genome analyses documents usefulness crosses divergent outbred detection characterization quantitative trait loci. genetic mapping major locus...
Domestication of wild boar ( Sus scrofa ) and subsequent selection have resulted in dramatic phenotypic changes domestic pigs for a number traits, including behavior, body composition, reproduction, coat color. Here we used whole-genome resequencing to reveal some the loci that underlie evolution European pigs. Selective sweep analyses revealed strong signatures at three harboring quantitative trait explain considerable part one most characteristic morphological pig—the elongation back an...
The dog was the first domesticated animal but it remains uncertain when domestication process began and whether occurred just once or multiple times across Northern Hemisphere. To ascertain value of modern genetic data to elucidate origins domestication, we analyzed 49,024 autosomal SNPs in 1,375 dogs (representing 35 breeds) 19 wolves. After combining our with previously published data, contrasted signatures 121 breeds a worldwide archeological assessment earliest remains. Correlating...
Abstract Background Real-time quantitative PCR (qPCR) is a method for rapid and reliable quantification of mRNA transcription. Internal standards such as reference genes are used to normalise levels between different samples an exact comparison transcription level. Selection high quality crucial importance the interpretation data generated by real-time qPCR. Results In this study nine commonly were investigated in 17 pig tissues using qPCR with SYBR green. The included beta-actin ( ACTB ),...
A quantitative trait locus (QTL) analysis of growth and fatness data from a three generation pig experiment is presented. The population 199 F2 animals was derived cross between wild boar Large White pigs. Animals were typed for 240 markers spanning 23 Morgans 18 autosomes the X chromosome. series analyses are presented within least squares framework. First, these identify chromosomes containing loci controlling variation subsequently attempt to map QTLs locations chromosomes. This gives...
Whole transcriptome sequencing (RNA-seq) has become a standard for cataloguing and monitoring RNA populations. One of the main bottlenecks, however, is to correctly identify different classes RNAs among plethora reconstructed transcripts, particularly those that will be translated (mRNAs) from class long non-coding (lncRNAs). Here, we present FEELnc (FlExible Extraction LncRNAs), an alignment-free program accurately annotates lncRNAs based on Random Forest model trained with general features...
The extraordinary phenotypic diversity of dog breeds has been sculpted by a unique population history accompanied selection for novel and desirable traits. Here we perform comprehensive analysis using multiple test statistics to identify regions under in 509 dogs from 46 diverse newly developed high-density genotyping array consisting >170,000 evenly spaced SNPs. We first 44 genomic exhibiting extreme differentiation across breeds. Genetic variation these correlates with several traits that...
The functional annotation of livestock genomes is crucial for understanding the molecular mechanisms that underpin complex traits economic importance, adaptive evolution and comparative genomics. Here, we provide most comprehensive catalogue to date regulatory elements in pig (Sus scrofa) by integrating 223 epigenomic transcriptomic data sets, representing 14 biologically important tissues. We systematically describe dynamic epigenetic landscape across tissues functionally annotating 15...
Abstract The Farm Animal Genotype-Tissue Expression (FarmGTEx) project has been established to develop a public resource of genetic regulatory variants in livestock, which is essential for linking polymorphisms variation phenotypes, helping fundamental biological discovery and exploitation animal breeding human biomedicine. Here we show results from the pilot phase PigGTEx by processing 5,457 RNA-sequencing 1,602 whole-genome sequencing samples passing quality control pigs. We build pig...
Abstract Background Comparative whole genome analysis of Mammalia can benefit from the addition more species. The pig is an obvious choice due to its economic and medical importance as well evolutionary position in artiodactyls. Results We have generated ~3.84 million shotgun sequences (0.66X coverage) genome. data are hereby released (NCBI Trace repository with center name "SDJVP", project "Sino-Danish Pig Genome Project") together initial analysis. non-repetitive fraction was aligned UCSC...
Abstract A comprehensive genetic linkage map of the porcine genome has been developed by typing 128 markers in a cross between European Wild Boar and domestic breed (Large White). The marker set includes 68 polymerase chain reaction-formatted microsatellites, 60 anchored reference informative for comparative mapping 47 which have physically assigned situ hybridization. Novel multipoint assignments are provided 54 markers. covers about 1800 cM, average spacing is 11 cM. We used data to...
Human and mouse genome sequences contain roughly 100,000 regions that are unalignable in primary sequence neighbor corresponding alignable between both organisms. These pairs generally assumed to be nonconserved, although the level of structural conservation these has never been investigated. Owing limitations computational methods, comparative genomics lacking ability compare such nonconserved for conserved RNA elements. We have investigated presence elements by conducting a local...
ABSTRACT The prevalent porcine helminth, Ascaris suum , compromises pig health and reduces farm productivity worldwide. closely related human parasite, A. lumbricoides infects more than 800 million people representing a disease burden of 1.31 disability‐adjusted life years. infections are often chronic in nature, the parasites have profound ability to modulate their hosts' immune responses. This study provides first in‐depth characterisation extracellular vesicles (EVs) from different...
Fertility is one of the most important traits in dairy cattle, and has been steadily declining over last decades. We herein use state-of-the-art genomic tools, including high-throughput SNP genotyping next-generation sequencing, to identify a 3.3 Kb deletion FANCI gene causing brachyspina syndrome (BS), rare recessive genetic defect Holstein cattle. determine that despite very low incidence BS (<1/100,000), carrier frequency as high 7.4% breed. demonstrate this apparent discrepancy likely...
Obesity is a complex metabolic condition in strong association with various diseases, like type 2 diabetes, resulting major public health and economic implications. the result of environmental genetic factors their interactions, including genome-wide interactions. Identification co-expressed regulatory genes RNA extracted from relevant tissues representing lean obese individuals provides an entry point for identification pathways importance to development obesity. The pig, omnivorous animal,...
The prevalence of non-alcoholic fatty liver disease (NAFLD) has increased dramatically worldwide and, subsequently, also the risk developing steatohepatitis (NASH), hepatic fibrosis, cirrhosis and cancer. Today, weight loss is only available treatment, but administration fibroblast growth factor 21 (FGF21) analogues have, in addition to loss, shown improvements on metabolic health mechanisms behind are not entirely clear. aim this study was investigate profile response FGF21 treatment....
Sled dog arctic adaptations go far back Dogs have been used for sledding in the Arctic as ∼9500 years ago. However, relationships among earliest sled dogs, other populations, and wolves are unknown. Sinding et al. sequenced an ancient dog, 10 modern wolf analyzed their genetic with dogs. This analysis indicates that dogs represent lineage going at least 9500 bred ancestors of precontact American gene flow between likely stopped before Science , this issue p. 1495
Summary A comprehensive linkage map, including 236 linked markers with a total sex‐average map length of about 2300 cM, covering nearly all parts the pig genome has been established. Linkage groups were assigned to 18 autosomes, X chromosome and X/Y pseudoautosomal region. Several new gene assignments made assignment group U1 (EAK‐HPX) 9. The includes 77 type I loci informative for comparative mapping 72 in situ mapped physically anchoring on chromosomes. highly significant heterogeneity...
Myxomatous mitral valve disease (MMVD) is the most common heart in dogs. It characterized by chronic progressive degenerative lesions of valve. The leaflets become thickened and prolapse into left atrium resulting regurgitation (MR). MMVD prevalent small to medium sized dog breeds, Cavalier King Charles Spaniels (CKCS) particular. onset highly age dependent, at 10 years, nearly all CKCS are affected. incidence a similar humans—mitral prolapse—is 1–5%. By defining CKCSs with an early as cases...