A5100325965- Genetic and phenotypic traits in livestock
- Genetic Mapping and Diversity in Plants and Animals
- Cancer-related molecular mechanisms research
- Genetics and Plant Breeding
- Rice Cultivation and Yield Improvement
- Animal Nutrition and Physiology
- Animal Genetics and Reproduction
- MicroRNA in disease regulation
- GABA and Rice Research
- Particle physics theoretical and experimental studies
- Molecular Biology Techniques and Applications
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
- Astrophysics and Cosmic Phenomena
- Neutrino Physics Research
- Muscle Physiology and Disorders
- RNA Research and Splicing
- Meat and Animal Product Quality
- Peroxisome Proliferator-Activated Receptors
- Gene expression and cancer classification
- Reproductive Physiology in Livestock
- Cancer-related gene regulation
- Diabetes and associated disorders
- Reproductive Biology and Fertility
- Livestock Farming and Management
South China Agricultural University
2016-2025
Second Xiangya Hospital of Central South University
2021-2025
Central South University
2021-2025
Tsinghua University
2025
Xinjiang Agricultural University
2025
Beijing Sport University
2024
Guangdong Academy of Medical Sciences
2024
Southern Medical University
2024
Guangdong Provincial People's Hospital
2024
Columbia University Irving Medical Center
2024
Utilizing the whole genomic variation of complex traits to predict yet-to-be observed phenotypes or unobserved genetic values via genome prediction (WGP) and infer underlying architecture wide association study (GWAS) is an interesting fast developing area in context human disease studies as well animal plant breeding. Though thousands significant loci for several species were detected GWAS past decade, they not used directly improve WGP due lack proper models. Here, we propose a generalized...
Abstract The Farm Animal Genotype-Tissue Expression (FarmGTEx) project has been established to develop a public resource of genetic regulatory variants in livestock, which is essential for linking polymorphisms variation phenotypes, helping fundamental biological discovery and exploitation animal breeding human biomedicine. Here we show results from the pilot phase PigGTEx by processing 5,457 RNA-sequencing 1,602 whole-genome sequencing samples passing quality control pigs. We build pig...
ABSTRACT High‐throughput single‐cell RNA‐seq (scRNA‐seq) data contains an excess of zero values, which can be contributed by unexpressed genes and detection signal dropouts. Existing imputation methods fail to distinguish between these two types zeros. In this study, we introduce a statistical framework that effectively differentiates true zeros (lack expression) from false (dropouts). By focusing only on imputing the dropout zeros, developed new tool, scRecover. Our approach utilizes...
Understanding the dynamics of muscle transcriptome during development and between breeds differing in growth is necessary to uncover complex mechanism underlying development. Herein, we present first transcriptome-wide longissimus dorsi research concerning Lantang (LT, obese) Landrace (LR, lean) pig 10 time-points from 35 days-post-coitus (dpc) 180 days-post-natum (dpn) using Solexa/Illumina's Genome Analyzer. The data demonstrated that myogenesis was almost completed before 77 dpc, but...
Obtaining accurate predictions of unobserved genetic or phenotypic values for complex traits in animal, plant, and human populations is possible through whole-genome prediction (WGP), a combined analysis genotypic data. Because the underlying architecture trait interest an important factor affecting model selection, we propose new strategy, termed BLUP|GA (BLUP-given architecture), which can use information within dataset at hand rather than from public sources. This achieved by using...
With its low-cost, label-free and non-destructive features, Raman spectroscopy is becoming an attractive technique with high potential to discriminate the causative agent of bacterial infections per se. However, it challenging achieve consistency accuracy spectra from numerous species phenotypes, which significantly hinders practical application technique. In this study, we analyzed surfaced enhanced (SERS) through machine learning algorithms in order pathogens quickly accurately. Two...
During litchi (Litchi chinensis Sonn.) fruit ripening, two major physiological changes, degreening (Chl degradation) and pigmentation (anthocyanin biosynthesis), are visually apparent. However, the specific factor triggering this important transition is still unclear. In present study, we found that endogenous ABA content increased sharply when Chl breakdown was initiated level peaked just before onset of anthocyanin accumulation, suggesting plays an role during pigmentation. We...
Muscle invasive bladder cancers (BCs) can be divided into 2 major subgroups-basal/squamous (BASQ) tumors and luminal tumors. Since Pparg has low or undetectable expression in BASQ tumors, we tested the effects of rosiglitazone, agonist, a mouse model BC. We find that rosiglitazone reduces proliferation while treatment with plus trametinib, MEK inhibitor, induces apoptosis tumor volume by 91% after 1 month. Rosiglitazone trametinib also induce shift from to differentiation which our analysis...
Approximately 40% of individuals with diabetes worldwide are at risk developing diabetic kidney disease (DKD), which is not only the leading cause failure, but also significantly increases cardiovascular disease, causing significant societal health and financial burdens. This study aimed to describe burden DKD explore its cross-country epidemiological status, predict development trends, assess factors sociodemographic transitions. Based on Global Burden Diseases (GBD) Study 2021, data due...
High-quality semen is an essential factor for the success of artificial insemination, and revealing genetic structure pig traits helps improve quality. This study aimed to identify candidate genes associated with in three breeds (Duroc, Landrace, Yorkshire) through weighted GWAS multi-tissue transcriptome analysis. In this study, Duroc, Yorkshire, we performed four (sperm motility, sperm progressive abnormality rate, total count) using 936 pigs analysis 34 tissues RNA-seq data 5457 from...
The tall and short traits of chickens are significant indicators for evaluating their growth development. Tall have longer cycles, allowing them to accumulate sufficient nutrients resulting in superior meat quality. This study aims investigate the Baicheng Fatty identify relevant candidate genes. A total 25 were selected this research, where whole genome resequencing was performed on all samples uncover genetic variations influencing traits. Additionally, transcriptome sequencing conducted...
Abstract Gao et al. propose several approaches to incorporate gene annotation into genomic prediction and evaluate these new methods on populations..... Today, (GP) is an established technology in plant animal breeding programs. Current standard are purely based statistical considerations but do not make use of the abundant biological knowledge, which easily available from public databases. Major questions that have be answered before prior information can used routinely GP types used, at...
Genome-wide association studies and genomic predictions are thought to be optimized by using whole-genome sequence (WGS) data. However, sequencing thousands of individuals interest is expensive. Imputation from SNP panels WGS data an attractive less expensive approach obtain The aims this study were investigate the accuracy imputation provide insight into design execution genotype imputation.We genotyped 450 chickens with a 600 K array, sequenced 24 key whole genome re-sequencing. Accuracy...
Abstract Substantial evidence has shown that DNA methylation regulates the initiation of ovarian and sexual maturation. Here, we investigated genome-wide profile in porcine ovaries at single-base resolution using reduced representation bisulfite sequencing. The biological variation was minimal among three replicates. We found hypermethylation frequently occurred regions with low gene abundance, while hypomethylation high abundance. around transcriptional start sites negatively correlated...
South China indigenous pigs are famous for their superior meat quality and crude feed tolerance. Saba Baoshan without saddleback were located in the high-altitude area of Yunnan Province, while Tunchang Ding’an with low-altitude Hainan Province. Although these different appearance, underlying genetic differences have not been investigated. In this study, based on single-nucleotide polymorphism (SNP) genotypes 124 samples, both cross-population extended haplotype homozygosity (XP-EHH)...
Semen traits play a key role in the pig industry because boar semen is widely used purebred and crossbred pigs. The production of high-quality crucial to ensuring good result artificial insemination. With wide application insemination industry, more attention has been paid improvement by genetic selection. purpose this study was identify regions candidate genes associated with Duroc boars. We weighted single-step GWAS sperm motility, progressive abnormality rate total count In pigs, three...
Genomic prediction with imputed whole-genome sequencing (WGS) data is an attractive approach to improve predictive ability low cost. However, high accuracy has not been realized using this method in livestock. In study, we 435 individuals from 600K single nucleotide polymorphism (SNP) chip WGS different reference panels. We also investigated the of genomic best linear unbiased (GBLUP) panels, linkage disequilibrium (LD)-based marker pruning, and pre-selected variants based on Genome-wide...
Abstract Background Presently, multi-omics data (e.g., genomics, transcriptomics, proteomics, and metabolomics) are available to improve genomic predictors. Omics not only offers new layers for prediction but also provides a bridge between organismal phenotypes genome variation that cannot be readily captured at the sequence level. Therefore, using select feature markers is feasible strategy accuracy of prediction. In this study, simultaneously whole-genome sequencing (WGS) gene expression...
Abstract In livestock, genome‐wide association studies (GWAS) are usually conducted in a single population (single‐GWAS) with limited sample size and detection power. To enhance the power of GWAS, meta‐analysis GWAS (meta‐GWAS) mega‐analysis (mega‐GWAS) have been proposed to integrate data from multiple populations at level summary statistics or individual data, respectively. However, there is lack comparison for these different strategies, which makes it difficult guide best practice...
Background: In recent years, with the development of high-throughput sequencing technology and commercial availability genotyping bead chips, more attention is being directed towards utilization abundant genetic markers in animal plant breeding programs, human disease risk prediction personal medicine.Several useful approaches to accomplish genomic have been developed used widely, but still room for improvement gain accuracy.In this study, an improved Bayesian approach, termed BayesBπ, which...
To investigate the genetic diversity, population structure, extent of linkage disequilibrium (LD), effective size (Ne), and selection signatures in indigenous pigs from Guangdong Guangxi China, 226 belonging to ten diverse populations were genotyped using single nucleotide polymorphism (SNP) chips. The divergence between Chinese Western was determined based on SNP chip data. Low diversity Dahuabai (DHB), Luchuan (LC), Lantang (LT), Meihua (MH) pigs, introgression into Longlin (LL), MH,...
Background: In western swine breeds, up to 30% of embryonic losses occur during early pregnancy, and the majority happens implantation. this period, maternal recognition pregnancy begins blastocysts undergo dramatic morphologic changes. As with other species, changes in uterine environment plays an important role process embryo implantation pigs. Erhualian (ER) pigs, one Chinese Taihu are known have highest litter size world. Experiments demonstrated that greater survival on gestation day...