A5100396992- Thyroid Cancer Diagnosis and Treatment
- Thyroid and Parathyroid Surgery
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Circular RNAs in diseases
- Head and Neck Anomalies
- Ferroptosis and cancer prognosis
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- BRCA gene mutations in cancer
- Thyroid Disorders and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Peptidase Inhibition and Analysis
- Pancreatic and Hepatic Oncology Research
- Cancer, Lipids, and Metabolism
- Biomarkers in Disease Mechanisms
- Neuroendocrine Tumor Research Advances
- Cancer Mechanisms and Therapy
- Pituitary Gland Disorders and Treatments
- Cancer-related gene regulation
- Estrogen and related hormone effects
- Hepatocellular Carcinoma Treatment and Prognosis
- Cell death mechanisms and regulation
- Cancer, Hypoxia, and Metabolism
First Hospital of China Medical University
2016-2025
China Medical University
2016-2025
Zhejiang University
2023-2025
First Affiliated Hospital of Bengbu Medical College
2006-2025
Shanghai Jiao Tong University
2020-2025
Shanghai Sixth People's Hospital
2025
Shanghai Clinical Research Center
2025
State Key Laboratory of Food Science and Technology
2025
Jiangnan University
2025
Yangzhou University
2025
N6-methyladenosine (m6A) modification is the most common chemical in mammalian mRNAs, and it plays important roles by regulating several cellular processes. Previous studies report that m6A implicated modulating tumorigenesis progression. However, dysregulation of effect demethylase fat-mass obesity-associated protein (FTO) on glucose metabolism has not been fully elucidated papillary thyroid cancer (PTC).Quantitative real-time PCR (qRT-PCR), western blotting immunohistochemistry were...
Deregulated expression of circular RNA (circRNA) has been determined to be important in carcinogenesis and progression; however, the most common type primary malignant bone tumor osteosarcoma, roles circRNA cancer development still remain elucidated. Here, we found that UBAP2 (circUBAP2) is significantly increased human osteosarcoma tissues as compared those matched controls. Increased circUBAP2 was correlated with progression prognosis. Furthermore, could promote growth inhibit apoptosis...
Inflammasomes, which mediate maturation of interleukin-1β (IL-β) and interleukin-18 (IL-18) lead to pyroptosis, have been linked various autoimmune disorders. This study investigated whether they are involved in the pathogenesis thyroiditis (AIT).We collected thyroid tissues from 50 patients with AIT sex- age-matched controls. Serum levels free T3, T4, thyrotropin, peroxidase antibody (TPOAb), thyroglobulin (TgAb) were measured by electrochemiluminescent immunoassays. Expression several...
DNA hypomethylation was previously implicated in cancer progression and metastasis. The purpose of this study to examine whether stilbenoids, resveratrol pterostilbene thought exert anticancer effects, target genes with oncogenic function for de novo methylation silencing, leading inactivation related signaling pathways. Following Illumina 450K, genome-wide analysis reveals that stilbenoids alter patterns breast cells. On average, 75% differentially methylated have increased methylation,...
Osteoarthritis (OA) is the most common type of arthritis with no effective therapy. Subchondral bone and overlying articular cartilage are closely associated function as "osteo-chondral unit" in joint. Abnormal mechanical load leads to activated osteoclast activity increased resorption subchondral bone, which implicated onset OA pathogenesis. Thus, inhibiting activation could prevent onset. Betaine, isolated from Lycii Radicis Cortex (LRC), has been demonstrated exert anti-inflammatory,...
Abstract Papillary thyroid carcinoma (PTC) is the main type of carcinoma. Despite good prognosis, some PTC patients may deteriorate into more aggressive diseases, leading to poor survival. Molecular technology has been increasingly used in diagnosis and treatment In this study, we identified that RNA Binding Motif Protein 47 (RBM47) was downregulated tissues cells, overexpression RBM47 could activate autophagy inhibit proliferation cells. promotes but can not bind directly Forkhead Box O3...
Determination of malignancy in thyroid nodules remains a major diagnostic challenge. Here we report the feasibility and clinical utility developing an AI-defined protein-based biomarker panel for classification nodules: based initially on formalin-fixed paraffin-embedded (FFPE), further refined fine-needle aspiration (FNA) tissue specimens minute amounts which pose technical challenges other methods. We first developed neural network model 19 protein biomarkers proteomes 1724 FFPE samples...
<h2>Abstract</h2> Phosphorus is an essential macronutrient for plant development and metabolism, plants have evolved ingenious mechanisms to overcome phosphate (Pi) starvation. However, the molecular underlying regulation of shoot root architecture by low phosphorus conditions coordinated utilization Pi nitrogen remain largely unclear. Here, we show that Nodulation Signaling Pathway 1 (NSP1) NSP2 regulate rice tiller number promoting biosynthesis strigolactones (SLs), a class phytohormones...
Although circular RNAs (circRNAs) are involved in cell proliferation, differentiation, apoptosis, and invasion, the underlying regulatory mechanisms of circRNAs thyroid cancer have not been fully elucidated. This article aimed to study role circRNA regulated by N6-methyladenosine modification papillary (PTC). Quantitative real-time PCR, western blotting, immunohistochemistry were used investigate expressions nuclear receptor-interacting protein 1 (circNRIP1) PTC tissues adjacent noncancerous...
Abstract Nuclear paraspeckle assembly transcript 1 (NEAT1), a long non-coding RNA (lncRNA), is core structural component of paraspeckles and essential for formation. NEAT1 comprises two different isoforms: NEAT1_1 (3.7 kb) NEAT1_2 (23 kb). Recently, has been shown to have oncogenic roles facilitate tumorigenesis in various human cancers. However, the function papillary thyroid cancer (PTC) not well understood. The relative expression levels NEAT1_2, ATPase family AAA domain-containing...
The incidence of papillary thyroid cancer (PTC) is markedly higher in women than men during the reproductive years. In vitro studies have suggested that estrogen may play an important role development and progression PTC through receptors (ERs). This study aimed to investigate expression patterns two main ER subtypes, α β1 (wild-type ERβ), tissue their clinical significance. Immunohistochemical staining sections was performed detect female patients with (n = 89) nodular goiter (NTG; n 30)...
Abstract With the increasing incidence of papillary thyroid cancer (PTC), more attention has been paid to exploring mechanism PTC initiation and progression. In addition, ectopic expression long noncoding RNAs (lncRNAs) is reported play a pivotal role in multiple human cancers. Based on these findings, we examined lncRNA ABHD11 antisense RNA 1 (ABHD11-AS1) its clinical significance, biological function PTC. First, analyzed ABHD11-AS1 The Cancer Genome Atlas (TCGA) Gene Expression Omnibus...
Papillary thyroid carcinoma (PTC) is the most common type of cancer (TC), accounting for more than 80% all cases. Ferroptosis a novel iron-dependent and Reactive oxygen species (ROS) reliant cell death which distinct from apoptosis, necroptosis pyroptosis. Considerable studies have demonstrated that ferroptosis involved in biological process various cancers. However, role PTC remains unclear. This study aims at exploring expression ferroptosis-related genes (FRG) their prognostic values PTC.
Combining immune checkpoint blockade (ICB) therapy with chemotherapy can enhance the efficacy of ICB and expand its indications. However, limited tumor specificity drugs results in severe adverse reactions. Additionally, low tissue penetration immune-related events associated monoclonal antibodies restrict their widespread application. To address challenges faced by traditional combination therapies, we design a dual-responsive engineered nanoparticle based on ferritin (denoted as CMFn@OXA),...
Pediatric papillary thyroid carcinomas (PPTCs) exhibit high inter-tumor heterogeneity and currently lack widely adopted recurrence risk stratification criteria. Hence, we propose a machine learning-based objective method to individually predict their risk. We retrospectively collect evaluate the clinical factors proteomes of 83 pediatric benign (PB), 85 malignant (PM) 66 adult (AM) nodules, quantify 10,426 proteins by mass spectrometry. find 243 121 significantly dysregulated from PM vs. PB...