A5074917932- Liver Disease Diagnosis and Treatment
- Lipoproteins and Cardiovascular Health
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Microbial Community Ecology and Physiology
- Cholesterol and Lipid Metabolism
- Cancer, Lipids, and Metabolism
- Hepatitis C virus research
- Peroxisome Proliferator-Activated Receptors
- Diet, Metabolism, and Disease
- Liver Disease and Transplantation
- Genomics and Phylogenetic Studies
- Fungal Biology and Applications
- Lipid metabolism and disorders
- Fatty Acid Research and Health
- Liver physiology and pathology
- Antioxidant Activity and Oxidative Stress
- Hormonal Regulation and Hypertension
- Pancreatic function and diabetes
- Gut microbiota and health
- Cell Adhesion Molecules Research
- Hepatitis B Virus Studies
- Growth Hormone and Insulin-like Growth Factors
- Diet and metabolism studies
- Plant biochemistry and biosynthesis
- Drug Transport and Resistance Mechanisms
National Institute of Advanced Industrial Science and Technology
2014-2025
Saga Medical School Hospital
1995-2024
Tokyo University of Science
2024
Shirasagi Hospital
2008-2023
Gifu University
2019-2021
University of Tsukuba
2021
Fukuoka Tokushukai Hospital
2020
Rohto Pharmaceutical (Japan)
2014
The University of Tokyo
2004-2012
Saga University
1994-2009
Coal-bed methane is one of the largest unconventional natural gas resources. Although microbial activity may greatly contribute to coal-bed formation, it unclear whether complex aromatic organic compounds present in coal can be used for methanogenesis. We show that deep subsurface-derived Methermicoccus methanogens produce from more than 30 types methoxylated (MACs) as well coals containing MACs. In contrast known methanogenesis pathways involving one- and two-carbon compounds, this...
ABSTRACT Microbiologists have been using agar growth medium for over 120 years. It revolutionized microbiology in the 1890s when microbiologists were seeking effective methods to isolate microorganisms, which led successful cultivation of microorganisms as single clones. But there has a disparity between total cell counts and cultivable on plates, often referred “great plate count anomaly,” that long phenomenon still remains unsolved. Here, we report common practice employed prepare hidden...
Hepatocellular carcinoma (HCC) is characterized by frequent recurrence, even after curative treatment. Vitamin K2, which has been reported to reduce HCC development, may be effective in preventing recurrence. Patients who underwent ablation or resection of were randomly assigned receive placebo, 45 mg/day, 90 mg/day vitamin K2 double-blind fashion. recurrence was surveyed every 12 weeks with dynamic computed tomography/magnetic resonance imaging, HCC-specific tumor markers monitored 4 weeks....
One highly diverse phylogenetic group of Bacteria, Ca . Patescibacteria, remains poorly understood, but, from the few cultured representatives and metagenomic investigations, they are thought to live symbiotically or parasitically with other bacteria even eukarya.
Methane-generating archaea drive the final step in anaerobic organic compound mineralization and dictate carbon flow of Earth's diverse anoxic ecosystems absence inorganic electron acceptors. Although such Archaea were presumed to be restricted life on simple compounds like hydrogen (H
alpha-Tocopherol transfer protein (alpha TTP) present in rat liver cytosol specifically binds this vitamin and enhances its between separate membranes. We previously reported purification of alpha TTP showed that two isoforms exist liver, which the isoelectric points are 5.0 5.1, respectively (Sato, Y., Hagiwara, K., Arai, H., Inoue, K. (1991) FEBS Lett. 288, 41-45). In paper, we have isolated a cDNA clone with 2194 base pairs encoding from library. The amino acid sequence deduced contained...
The high recurrence rate of hepatocellular carcinoma (HCC) determines the long-term prognosis for patients with HCC. In current study, authors tested effects menatetrenone, a vitamin K2 analog, on recurrent HCC and survival after curative treatment.Sixty-one who were diagnosed as free surgical resection or percutaneous local ablation assigned randomly to either menatetrenone group (n = 32 patients) control 29 patients). Patients in received daily oral dose 45 mg menatetrenone. Disease rates...
To verify whether members of the phylum
AIM: Primary biliary cirrhosis (PBC) is a chronic, cholestatic disease of autoimmune etiology, the histology which shows destruction intrahepatic bile duct and portal inflammation.Ursodeoxycholic acid (UDCA) now used as first-line drug for asymptomatic PBC (aPBC) because it reported that UDCA decreases mortality prolongs time liver transplantation.However, only 20-30% patients respond fully to UDCA.Recently, lipoproteinlowering agents have been found be effective PBC.The aim this study was...
Sparassis crispa (SC), Hanabiratake in Japanese, is an edible mushroom with medicinal properties, that contains more than 40% β-D-glucan. It was concluded from results of the methylation study β-D-glucan SC (SBG) composed a backbone β-(1→3)-linked D-glucopyranosyl residues, and had β-D-glucopyranosyl groups joined through O-6 O-2 D-glucose backbone. We purified SBG investigated its anti-angiogenic functions anti-metastatic effects on neoplasm using different animal models. The oral...
Duckweeds are small, fast growing, and starch- protein-rich aquatic plants expected to be a next generation energy crop an excellent biomaterial for phytoremediation. Despite such importance, very little is known about duckweed–microbe interactions that would key biological factor efficient industrial utilization of duckweeds. Here we first report the duckweed growth promoting ability bacterial strains belonging phylum Acidobacteria, members which inhabit soils terrestrial plants, but their...
Although alcohol intake as well hepatitis viruses has been associated with hepatocellular carcinoma (HCC), gene-alcohol interactions on HCC risk remain to be elucidated. We conducted a case-control study examine whether polymorphisms of dehydrogenase 2 (ADH2) and aldehyde (ALDH2) modified the depending amount intake. ADH2 ALDH2 genotyping was performed by duplex polymerase chain reaction confronting two-pair primers in 209 newly diagnosed cases different controls [275 hospital 381 patients...
Coffee use has consistently been associated with lower serum liver enzyme levels and a reduced risk of cirrhosis. A limited number cohort case‐control studies also suggest decreased hepatocellular carcinoma (HCC) among coffee drinkers, but mostly without consideration hepatitis virus infection. In the present study, we recruited 209 incident HCC cases three different controls (1308 community controls, 275 hospital 381 patients chronic disease [CLD] HCC), all whom were aged 40–79 years...
Abstract Purpose: Menatetrenone, a vitamin K2 analogue, plays an important role in the production of blood coagulation factors. Menatetrenone has also bee shown to have antineoplastic effects against several cancer cell lines including hepatocellular carcinoma (HCC) cells. However, mechanisms by which inhibits HCC growth not fully clarified, and we therefore investigated molecular basis K2–induced inhibition Experimental Design: cells were treated with expression growth-related genes...
Crop rotation and intercropping with Allium plants suppresses Fusarium wilt in various crops. However, the mechanisms underlying this phenomenon have not been fully elucidated. This study was designed to assess role of microorganisms inhabiting rhizospheres antifungal compounds produced by roots suppression cultivation. Suppression cucumber pathogen multiplication (Welsh onion and/or onion)-cultivated soils were eliminated heat treatment at 60 °C, whereas those Welsh onion-root extract lost...
Background —Laminin receptors are involved in cell-extracellular matrix interactions malignant cells that show invasion and metastasis. Hepatocellular carcinoma frequently shows early into blood vessels, intrahepatic extrahepatic metastases. However, the role of laminin hepatocellular is unknown. Aims —To examine expression mRNA for their isoforms carcinoma. Methods —The several receptors, including α1 integrin, α6 integrin its α6A α6B, β1 β1A β1B, 32kD/67kDa binding protein was examined...