A5053377268- Hydrogels: synthesis, properties, applications
- Bone Metabolism and Diseases
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Osteoarthritis Treatment and Mechanisms
- Bone Tissue Engineering Materials
- Extracellular vesicles in disease
- 3D Printing in Biomedical Research
- Smart Grid and Power Systems
- Bone health and treatments
- Power Systems and Technologies
- Advanced Drug Delivery Systems
- Bone and Joint Diseases
- Advanced Materials and Mechanics
- Graphene and Nanomaterials Applications
- Bone health and osteoporosis research
- Power Systems Fault Detection
- HVDC Systems and Fault Protection
- Nanoplatforms for cancer theranostics
- Cancer-related molecular mechanisms research
- Power Systems and Renewable Energy
- Hip and Femur Fractures
- Mesenchymal stem cell research
- NF-κB Signaling Pathways
- Micro and Nano Robotics
Shanghai Jiao Tong University
2012-2025
XinHua Hospital
2023-2025
Soochow University
2025
Sir Run Run Shaw Hospital
2025
Zhejiang University
2023-2025
Shanghai University
2012-2024
Wuhan University
2008-2024
New York University Shanghai
2024
Zhongnan Hospital of Wuhan University
2024
Shaoxing University
2023
Abstract Bone related diseases have caused serious threats to human health owing their complexity and specificity. Fortunately, the unique 3D network structure with high aqueous content functional properties, emerging hydrogels are regarded as one of most promising candidates for bone tissue engineering, such repairing cartilage injury, skull defect, arthritis. Herein, various design strategies synthesis methods (e.g., 3D‐printing technology nanoparticle composite strategy) introduced...
Light-driven synthetic micro-/nanomotors have attracted considerable attention due to their potential applications and unique performances such as remote motion control adjustable velocity. Utilizing harmless renewable visible light supply energy for in water represents a great challenge. In view of the outstanding photocatalytic performance bismuth oxyiodide (BiOI), visible-light-driven BiOI-based Janus micromotors been developed, which can be activated by broad spectrum light, including...
Exosomes, also known as extracellular vesicles, are naturally occurring, biocompatible, and bioacive nanoparticles ranging from 40 to 150 nm in diameter. Bone-secreted exosomes play important roles bone homeostasis, the interruption of which can lead diseases such osteoporosis, rheumatoid arthritis, osteopetrosis. Though relationship between vascular homeostasis has been recognized recently, role endothelial cell (EC)-secreted (EC-Exos) is not well understood. Herein, we found that EC-Exos...
The differentiation shift from osteogenesis to adipogenesis of bone marrow mesenchymal stem cells (BMSCs) characterizes many pathological loss conditions. Stromal cell-derived factor-1 (SDF1) is highly enriched in the for C-X-C motif chemokine receptor 4 (CXCR4)-positive hematopoietic cell (HSC) homing and tumor metastasis. In this study, we displayed CXCR4 on surface exosomes derived genetically engineered NIH-3T3 cells. CXCR4+ selectively accumulated marrow. Then, fused with liposomes...
Systematic bone loss is commonly complicated with inflammatory bowel diseases (IBDs) unclear pathogenesis and uncertain treatment. In experimental colitis mouse models established by dextran sulfate sodium IL-10 knockout induced piroxicam, mass quality are significantly decreased. Colitis mice demonstrate a lower formation rate fewer osteoblasts in femur. Bone marrow mesenchymal stem/stromal cells (BMSCs) from tend to differentiate into adipocytes rather than osteoblasts. Serum patients IBD...
Abstract With an increasingly aging society, bone defects and fractures have become significant threats to human health quality of life. Currently, autologous allogeneic grafts remain the “gold standard” for clinical treatment repair. However, transplantation is still clinically insufficient, owing its substantial limitations, such as graft rejection, donor functional defects, risk infection. Therefore, a variety biomaterials been developed facilitate advancement tissue engineering, focus...
Abnormal subchondral bone remodeling featured by overactivated osteoclastogenesis leads to articular cartilage degeneration and osteoarthritis (OA) progression, but the mechanism is unclear. We used lymphocyte cytosolic protein 1 (Lcp1) knockout mice suppress osteoclasts in a OA model with anterior cruciate ligament transection (ACLT), Lcp1-/- showed decreased retarded degeneration. For mechanisms, activated induced type-H vessels elevated oxygen concentration, which ubiquitylated...
Diabetes mellitus is a chronically inflamed disease that predisposes to delayed fracture healing. Macrophages play key role in the process of healing by undergoing polarization into either M1 or M2 subtypes, which respectively exhibit pro-inflammatory anti-inflammatory functions. Therefore, modulation macrophage subtype beneficial for Exosomes perform an important improving osteoimmune microenvironment due their extremely low immunogenicity and high bioactivity. In this study, we extracted...
Abstract A new double-layer, pH-sensitive, composite hydrogel sustained-release system based on polysaccharides and synthetic polymers with combined functions of different inner/outer hydrogels was prepared. The inner core sodium alginate (SA) carboxymethyl cellulose (CMC), formed by physical crosslinking pH-sensitive property. polymer out-layer enhanced stability introduced chemical to eliminate the expansion diffusion content. physicochemical structure double-layer characterized....
The actin-bundling protein L-plastin (LPL) mediates the resorption activity of osteoclasts, but its therapeutic potential in pathological bone loss remains unexplored. Here, we report that LPL knockout mice show increased mass and cortical thickness with more mononuclear tartrate-resistant acid phosphatase-positive cells, osteoblasts, CD31hiEmcnhi endothelial vessels, fewer multinuclear osteoclasts marrow periosteum. deletion impeded preosteoclasts fusion by inhibiting filopodia formation...
Osteoarthritis (OA) is the most common type of arthritis with no effective therapy. Subchondral bone and overlying articular cartilage are closely associated function as "osteo-chondral unit" in joint. Abnormal mechanical load leads to activated osteoclast activity increased resorption subchondral bone, which implicated onset OA pathogenesis. Thus, inhibiting activation could prevent onset. Betaine, isolated from Lycii Radicis Cortex (LRC), has been demonstrated exert anti-inflammatory,...
Skeletal muscle disorders have posed great threats to health. Selective delivery of drugs and oligonucleotides skeletal is challenging. Aptamers can improve targeting efficacy. In this study, for the first time, human muscle-specific ssDNA aptamers (HSM01, etc.) were selected identified with Systematic Evolution Ligands by Exponential Enrichment (SELEX). The HSM01 aptamer preferentially interacted cells
Cartilage defects are usually caused by acute trauma and chronic degeneration. However, it is still a great challenge to improve the repair of articular cartilage due limited self-regeneration capacity such defects. Herein, novel ROS-responsive in situ nanocomposite hydrogel loaded with kartogenin (KGN) bone marrow-derived stem cells (BMSCs) was designed constructed via enzymatic reaction fibrinogen thrombin. Meanwhile, thioketal (TK)-based liposome synthesized load chondrogenesis-inducing...