A5101811506- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Spinal Cord Injury Research
- Cancer-related molecular mechanisms research
- Mesenchymal stem cell research
- Cell death mechanisms and regulation
- Tendon Structure and Treatment
- Genomics, phytochemicals, and oxidative stress
- Lung Cancer Treatments and Mutations
- Receptor Mechanisms and Signaling
- Sirtuins and Resveratrol in Medicine
- Bone and Joint Diseases
- Sports injuries and prevention
- CRISPR and Genetic Engineering
- Circular RNAs in diseases
- Gout, Hyperuricemia, Uric Acid
- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Neurological Complications and Syndromes
- Peptidase Inhibition and Analysis
- Cancer-related Molecular Pathways
- Colorectal Cancer Treatments and Studies
- Shoulder Injury and Treatment
- Inflammasome and immune disorders
- Metabolism, Diabetes, and Cancer
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine
2023
Guang’anmen Hospital
2023
China Academy of Chinese Medical Sciences
2023
Beijing University of Chinese Medicine
2023
Hangzhou First People's Hospital
2023
Zhejiang University
2023
Jiangsu University
2019-2022
Army Medical University
2021
Second Military Medical University
2019
Soochow University
2006
Exosomes, also known as extracellular vesicles, are naturally occurring, biocompatible, and bioacive nanoparticles ranging from 40 to 150 nm in diameter. Bone-secreted exosomes play important roles bone homeostasis, the interruption of which can lead diseases such osteoporosis, rheumatoid arthritis, osteopetrosis. Though relationship between vascular homeostasis has been recognized recently, role endothelial cell (EC)-secreted (EC-Exos) is not well understood. Herein, we found that EC-Exos...
Exosomes derived from human umbilical cord mesenchymal stem cells (hucMSC-ex) are nano-sized membrane-bound vesicles that have been reported to facilitate skin regeneration and repair. However, the roles played by hucMSC-ex in ultraviolet (UV) radiation-induced photodamage underlying mechanisms remain unknown. To investigate functions of a rat model acute photodamage, immunofluorescence immunohistochemical staining, quantitative real-time-polymerase chain reaction (qRT-PCR), western blot,...
Osteolysis at the tendon-bone interface can impair pullout strength during healing and lead to surgery failure, but effects of clinical treatments are not satisfactory. Mesenchymal stem cell (MSC)-derived exosomes have been used as potent feasible natural nanocarriers for drug delivery proven enhance strength, indicating that MSC-derived could be a promising therapeutic strategy. In this study, we explored Scleraxis (Scx) dynamically expressed in PDGFRα(+) bone marrow-derived mesenchymal...
GLP-1 receptor agonists are clinically utilized for type 2 diabetes and obesity. In vitro in vivo preclinical studies were performed to assess the druggability of a novel small molecule biased agonist SAL0112.
Spinal cord injury (SCI) causes severe neurological dysfunction leading to a devastating disease of the central nervous system that is associated with high rates disability and mortality. Small extracellular vesicles (sEVs) derived from human umbilical mesenchymal stem cells (hucMSC-sEVs) have been explored as promising strategy for treating SCI. In this study, we investigated therapeutic effects intralesional administration hucMSC-sEVs after SCI determined potential mechanisms successful...
Abstract Bankground The tumor microenvironment (TME) is an internal environment composed of various cells and extracellular matrix. Cancer stem cell-derived exosomes (CSC-Exos), as essential messengers involved in processes, are important carriers for bidirectional communication between the play role microenvironment. Nevertheless, few bibliometric analyses have been systematically studied this field. Methods Therefore, we aimed to visualize research hotspots trends field through...
Abstract Background Osteoarthritis (OA), in which macrophage-driven synovitis is considered closely related to cartilage destruction and could occur at any stage, an inflammatory arthritis. However, there are no effective targets cure the progression of OA. The NLRP3 inflammasome synovial macrophages participates pathological process treatment strategies targeting it be approach for PIM-1 kinase, as a downstream effector many cytokine signaling pathways, plays pro-inflammatory role disease....
Abstract The tumor microenvironment (TME) is an internal environment composed of various cells and extracellular matrix. Cancer stem cells-derived exosomes (CSC-Exos), as essential messengers involved in processes, are important carriers for bidirectional communication between the play role microenvironment. Nevertheless, few bibliometric analyses have been systematically studied this field. Therefore, we aimed to visualize research hotspots trends field through bibliometrics comprehend...