A5043077320- Tendon Structure and Treatment
- Shoulder Injury and Treatment
- Sports injuries and prevention
- Orthopedic Surgery and Rehabilitation
- Exercise and Physiological Responses
- Silk-based biomaterials and applications
- Obstructive Sleep Apnea Research
- Knee injuries and reconstruction techniques
- Acupuncture Treatment Research Studies
- Wound Healing and Treatments
- Head and Neck Cancer Studies
- Nail Diseases and Treatments
- Bee Products Chemical Analysis
- Sinusitis and nasal conditions
- Head and Neck Surgical Oncology
- Urinary and Genital Oncology Studies
- Voice and Speech Disorders
- Nasal Surgery and Airway Studies
- Animal testing and alternatives
- Glutathione Transferases and Polymorphisms
- Radiomics and Machine Learning in Medical Imaging
- Dermatology and Skin Diseases
- Periodontal Regeneration and Treatments
- Dysphagia Assessment and Management
- Medical Imaging and Analysis
Army Medical University
2015-2025
Southwest Hospital
2015-2025
Huazhong University of Science and Technology
2023
Inner Mongolia Agricultural University
2023
Guilin Medical University
2023
Anhui Academy of Agricultural Sciences
2023
Affiliated Hospital of Southwest Medical University
2023
Army Medical College
2023
Nanjing General Hospital of Nanjing Military Command
2008-2016
Jinling Institute of Technology
2013
Tendinopathy is a common problem in sports medicine which can lead to severe morbidity. Aspirin, as the classical representative of non-steroidal anti-inflammatory drugs (NSAIDs) for its and analgesic actions, has been commonly used treating tendinopathy. While treatment effects on injury tendon healing are lacking, illuminating underlying mechanism may provide scientific basis clinical treatment.Firstly, we immunohistochemistry qRT-PCR detect changes CD14, CD206, iNOS, IL-6, IL-10, MMP-3,...
Abstract Tendon injuries are common musculoskeletal system disorders in clinical, but the regeneration ability of tendon is limited. stem cells (TSCs) have shown promising effect on tissue engineering and been used for treatment injury. Exosomes that serve as genetic information carriers implicated many diseases physiological processes, exosomes from TSCs injury repair unclear. The aim this study to make clear healing. were harvested conditioned culture media by a sequential centrifugation...
BACKGROUND:Inflammation after tendon-bone junction injury results in the formation of excessive scar tissue and poor biomechanical properties. Recent research has shown that exosomes derived from bone marrow stromal cells (BMSCs) can modulate inflammation during healing. Thus, our study aimed to enhance healing by use BMSC-derived (BMSC-Exos). MATERIAL AND METHODS:The mouse reconstruction model was established, mice were randomly divided into 3 groups: control group, hydrogel...
Osteolysis at the tendon-bone interface can impair pullout strength during healing and lead to surgery failure, but effects of clinical treatments are not satisfactory. Mesenchymal stem cell (MSC)-derived exosomes have been used as potent feasible natural nanocarriers for drug delivery proven enhance strength, indicating that MSC-derived could be a promising therapeutic strategy. In this study, we explored Scleraxis (Scx) dynamically expressed in PDGFRα(+) bone marrow-derived mesenchymal...
Background: The challenge of achieving effective tendon-to-bone healing remains a significant concern in sports medicine, necessitating further exploration. Biomimetic electrospun nanomaterials present promising avenues for improving this critical process. Purpose: To investigate the biological efficacy novel aligned-to-random PLGA/Col1-PLGA/nHA bilayer nanofiber membrane facilitating healing. Study Design: Controlled laboratory study. Methods: membrane’s composition, combining PLGA/Col1...
The healing of tendon-bone injuries is very difficult, often resulting in poor biomechanical performance and unsatisfactory functional recovery. insertion has a complex four distinct layers structure, previous studies have focused on promoting the regeneration fibrocartilage layer, neglecting role its bone end repair healing. This study focuses treadmill training at related mechanisms.
Abstract Tendinopathy is a common musculoskeletal system disorder in sports medicine, but regeneration ability of injury tendon limited. Tendon stem cells (TSCs) have shown the definitive treatment evidence for tendinopathy and injuries due to their tenogenesis capacity. Aspirin, as representative nonsteroidal anti‐inflammatory drugs its analgestic actions, has been commonly used treating clinical, effect aspirin on TSCs unclear. We hypothesized that could promote healing through inducing...
Studies have shown that the stem cell microenvironment is a key factor for maintenance or differentiation. In this study, we compared expression of 23 cytokines such as IL-6, IL-10, and TNFα between young aged rats during patellar tendon repair by cytokine microarray, found significant difference G-CSF, VEGF at 3, 7, 14 days post-operatively. The effects these factors on adipogenic differentiation TPSCs were examined through western blot oil red O experiments. It was had an inhibitive effect...
Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used in clinical practice to relieve fever and pain. Aspirin, as a representative NSAID, has been widely the treatment of tendinopathy. Some reports have demonstrated that aspirin can induce apoptosis cancer cells. However, evidence regarding for tendinopathy, especially effect this on tendon stem cells (TSCs), is lacking. Understanding tendinopathy may provide basis rational use NSAIDs practice. The aim our study was determine...
Tendon injury is associated with oxidative stress, leading to reactive oxygen species (ROS) production and inflammation. N-acetyl-L-cysteine (NAC) a potent antioxidant. However, how NAC affects the biological functions of tendon stem/progenitor cells (TSPCs) repair has not been clarified. METHOD: The impacts on viability, ROS production, differentiation TSPCs were determined cell counting kit-8, fluorescence staining, Western blotting, immunofluorescence. effect gene transcription in was...
Background/Aims: Dexamethasone (Dex)-induced spontaneous tendon rupture and decreased self-repair capability is very common in clinical practice. The metaplasia of adipose tissue the ruptured indicates that Dex may induce stem cells (TSCs) to differentiate into adipocytes, but mechanism remains unclear. In present study, we used vitro methods investigate effects on rat TSC differentiation molecular mechanisms underlying this process. Methods: First, qPCR Western blotting detect expression...
Abstract Achilles tendon injury is one of the challenges sports medicine, aetiology which remains unknown. For a long time, estrogen receptor β (ERβ) has been known as regulating factor metabolism in many connective tissues, such bone, muscle and cartilage, but little about its role tendon. Recent studies have implicated ERβ involved process healing. Tendon‐derived stem cells (TDSCs) are getting more attention physiological pathological process. In this study, we investigated how played...
Background. Tendon injuries are common clinical disorders. Due to the limited regeneration ability of tendons, tissue engineering technology is often used as an adjuvant treatment. This study explored molecular pathways underlying micropattern SF film-regulated TSPC propensity and their repairing effects highlight application value films. Methods. First, we characterized physical properties films on injured tendons in vivo. Then, seeded TSPCs vitro determined film-induced gene expression...
Tendon injuries are common musculoskeletal system disorders, but the ability for tendon regeneration is limited. Silk fibroin (SF) film may be suitable due to its excellent biocompatibility and physical properties. This study aimed at evaluating application value of bionic SF in regeneration.Tendon stem/progenitor cells (TSPCs) were isolated from rat Achilles characterized based on their surface marker expression multilineage differentiation potential. films with smooth or microstructure...
Abstract The frontal sinus surgery is difficult to perform but the ethmoid bulla a relative, constant landmark in middle turbinate that can improve surgery. purpose of this study was evaluate validity, security, and predominance approaches via route anterior bulla. data from 370 endoscopic cases our center were integrated retrospectively analyzed. Three hundred twenty-nine patients underwent An additional 27 with mini-trephination, 13 Draf II procedure, 1 patient had applied MELP (modified...
Background. Tendon injuries are common musculoskeletal disorders in clinic. Due to the limited regeneration ability of tendons, tissue engineering technology is often used as an effective approach treat tendon injuries. Silk fibroin (SF) films have excellent biological activities and physical properties, which suitable for regeneration. The present study aimed at preparing a SF film with bionic microstructure investigating its effects. Methods. A smooth surface or was prepared. After seeding...
Tendon stem/progenitor cells (TSPCs) play a vital role in tendon repair and regeneration. Previously we found more adipocytes accumulated the patellar injury sites aging rats compared with young ones, of which mechanism is still unknown. Here, want to identify whether erroneous differentiation TSPCs by accounts for adipocyte accumulation.TSPCs from were isolated propagated. Both induced differentiate into adipocytes, Oil red O staining, quantitative real-time polymerase chain reaction...
Mechanical stimulation is a key factor in the development and healing of tendon-bone insertion. Treadmill training an important rehabilitation treatment. This study aims to investigate benefits treadmill initiated on postoperative day 7 for insertion healing.A injury model was established 92 C57BL/6 male mice. All mice were divided into control groups by random digital table method. The group had full free activity cage, started 7. quality evaluated histology, immunohistochemistry, reverse...
Abstract Achilles tendon healing (ATH) remains an unanswered question in the field of sports medicine because it does not produce tissue with homology to previously uninjured tissue. Oestrogen receptor β (ERβ) is involved injury and repair processes tendons. Our previous study confirmed that ERβ plays a role early stage ATH by affecting adipogenesis, but its extracellular matrix (ECM) remodelling unknown. We established 4‐week model investigate mechanism through which affects at very...
Tendon diseases and injuries are a serious problem for the aged population, often leading to pain, disability significant decline in quality of life. The purpose this study was determine influence aging on biochemistry histology during tendon healing provide new strategy improving healing.A total 24 Sprague-Dawley rats were equally divided into young an group. A rat patellar defect model used study. samples collected at weeks 2 4, hematoxylin-eosin, alcian blue immunofluorescence staining...
Abstract Tendon-bone healing after injury is an unsolved problem. Several types of stem cells are used as seed cells. However, the optimal co-culture ratio different suitable for tissue engineering well stimulator facilitating differentiation in tendon-bone unclear. In this study, proliferation both bone marrow-derived (BMSCs) and tendon (TSCs) was increased at a 1:1 co-cultured ratio, suppressed by Tenascin C (TNC). TNC treatment can promote osteogenesis or chondrogenesis BMSCs TSCs under...