A5100704950- Nanoplatforms for cancer theranostics
- Advanced Nanomaterials in Catalysis
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Catalytic Processes in Materials Science
- melanin and skin pigmentation
- Skin Protection and Aging
- Dermatologic Treatments and Research
- Advanced Combustion Engine Technologies
- Nanocluster Synthesis and Applications
- Silk-based biomaterials and applications
- Wound Healing and Treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Nanoparticles: synthesis and applications
- Mitochondrial Function and Pathology
- Nanoparticle-Based Drug Delivery
- Advanced Polymer Synthesis and Characterization
- Vehicle emissions and performance
- MicroRNA in disease regulation
- Neuroblastoma Research and Treatments
- Graphene and Nanomaterials Applications
- Microstructure and Mechanical Properties of Steels
- Conducting polymers and applications
- Spinal Cord Injury Research
- Gold and Silver Nanoparticles Synthesis and Applications
Sichuan University
2019-2025
Hebei University
2023-2024
Nanjing Normal University
2023-2024
Jilin University
2024
Tianjin University
2014-2024
East China University of Science and Technology
2020-2024
Guizhou University
2023-2024
Shandong University
2024
Beijing Children’s Hospital
2021-2023
Capital Medical University
2021-2023
Abstract Flexible bioelectronics have attracted increasing research interests due to their wide range of potential applications in human motion detection, personal healthcare monitoring, and medical diagnosis. Recently, design fabrication strategies integrated with mussel‐inspired polydopamine (PDA) demonstrated many appealing properties, which meet the structural functional requirements high‐performance flexible bioelectronics. The inherent multiple reactive sites hierarchical interactions...
This paper strives to summarize the recent advances and current highlights of photoprotective polyphenolic sunscreens including structural functional relationships, design principle, UV-protection mechanism evaluation system.
The treatment of spinal cord injury (SCI) remains unsatisfactory owing to the complex pathophysiological microenvironments at site and limited regenerative potential central nervous system. Metformin has been proven in clinical animal experiments repair damaged structures functions by promoting endogenous neurogenesis. However, early stage acute SCI, adverse microenvironment sites, such as reactive oxygen species inflammatory factor storm, can prevent activation neural stem cells (NSCs)...
Platinum-based anticancer drugs such as cisplatin, oxaliplatin, and carboplatin are some of the most potent chemotherapeutic agents but have limited applications due to severe dose-limiting side effects a tendency for cancer cells rapidly develop resistance. The therapeutic index can be improved through use nanocarrier systems target efficiently. We developed unique strategy deliver platinum(IV) drug prostate by constructing glutathione-stabilized (Au@GSH) gold nanoparticles. Glutathione...
Abstract The therapeutic potential of nanomaterials toward oxidative damage relevant diseases has attracted great attentions by offering promising advantages compared with conventional antioxidants. Although different kinds nanoantioxidants have been well developed, the facile fabrication robust and efficient nanoscavengers is still met challenges like use toxic high‐cost subunits, involvement multistep synthetic process, redundant purification work. Herein, a direct strategy polyphenol...
Abstract Hydrogels have great potential applications in biomedical materials, but their complex physiological environments are severely limited by weak strength and biotoxicity. Generally, synthetic polymer hydrogels natural complementary advantages terms of mechanical biological activity. Herein, tannic acid (TA), a material, was introduced into the polyvinyl alcohol/collagen (PVA‐COL) double network to prepare hydrogel (PVA‐COL‐TA) with good bioactivity properties. The tensile composite...
Bacterial colonization on the surface of medical implanted devices and bacterial infection-induced biofilm have been a lethal risk for patients clinical treatment. While antibacterial coatings fabricated by layer-by-layer (LBL) assembly techniques well explored, facile preparation substrate-independent smart with on-demand antibiotics release profile excellent performance is still urgently needed. In this work, goal addressed LBL fabrication robust using naturally occurring commercially...
The crossing of blood-brain barrier (BBB) is essential for glioblastoma (GBM) therapy, and homotypic targeting an effective strategy to achieve BBB crossing. In this work, GBM patient-derived tumor cell membrane (GBM-PDTCM) prepared cloak gold nanorods (AuNRs). Relying on the high homology GBM-PDTCM brain membrane, GBM-PDTCM@AuNRs realize efficient selective targeting. Meanwhile, owing functionalization Raman reporter lipophilic fluorophore, are able generate fluorescence signals at lesion,...
Polydopamine (PDA) and poly(5,6-dihydroxyindole) (PDHI), both typical representatives of melanin-like polymers, are emerging as promising kinds photothermal functional materials with a similar polymeric structure. However, the chaos microstructure formed by free radical polymerization monomers still hinders efficient regulation their performances. Herein, we introduced condensation between aldehydes 5,6-dihydroxyindole (DHI) monomer during process to construct more D–A pairs, which can...
Polyphenolic antibacterial bio-adhesives were synthesised via polyphenols and acid anhydrides without solvent or catalyst. Upon heating, these adhesives could induce strong adhesion onto various substrates, while demonstrating excellent antibacterial, antiinfection biodegradability properties.
The usage of exogenous antioxidant materials to relieve oxidative stress offers an important strategy for the therapy stress-induced injuries. However, fabrication processes toward usually require involvement extra metal ions and organic agents, as well sophisticated purification steps, which might cause tremendous environmental induce unpredictable side effects in vivo. To address these issues, herein, we proposed a novel fabricate green nanoparticles efficiently modulating stress, was...
Although smart bio-glues have been well documented, the development of internal for non-invasive or minimally invasive surgery is still met with profound challenges such as safety risk and lack deep tissue penetration stimuli usage. Herein, a series are developed via integration o-nitrobenzene modified biopolymers up-conversion nanoparticles (UCNPs). Upon irradiation by near-infrared (NIR) light, prepared can undergo gelation process, which may further induce strong adhesion between tissues...
Abstract Poor prognosis is often expected after the treatment of intracerebral haemorrhage (ICH) when approach lacks effective neuroprotective interventions. Minocycline (Mino) a promising clinical candidate for acute ICH therapy that mainly inhibits activation microglia/macrophages. However, to address iron neurotoxicity, ferroptosis, and oxidative stress‐induced multiple neuroinjury mechanisms, effect minocycline still urgently needs be enhanced. To this issue, procyanidins (PACs), typical...
Abstract Although bio‐adhesives have achieved many progresses, creating robust bio‐glues that could withstand the complex physiological microenvironment remains a significant challenge such as limited bioadhesion strength and stability, well slow adhesion speed caused by pH, enzymes, salt, bacteria. Herein, series of strong are successfully fabricated using polyphenol–acrylamide–ruthenium crosslinking (PARC) reaction under visible light irradiation, involving acrylamides radical...
In the current years, polydopamine nanoparticles (PDA NPs) have been extensively investigated as an eumelanin mimic. However, unlike natural eumelanin, PDA NPs contain no 5,6-dihydroxyindole-2-carboxylic acid (DHICA)-derived units and may be limited in certain intrinsic properties; superior eumelanin-like nanomaterials are still actively being sought. Levodopa (l-DOPA) is a precursor expected to convert into DHICA further remain within final product through covalent or physical interactions....
Natural polyphenolic compounds play a vital role in nature and are widely utilized as building blocks the fabrication of emerging functional nanomaterials. Although diverse methodologies developed recent years, challenges purification, uncontrollable reaction processes additional additives persist. Herein, modular facile methodology is reported toward natural nanoparticles. By utilizing low frequency ultrasound (40 kHz), assembly various successfully induced, allowing for precise control...