A5100320756- Wound Healing and Treatments
- Mesenchymal stem cell research
- Pancreatic and Hepatic Oncology Research
- Cancer and Skin Lesions
- Hemostasis and retained surgical items
- Hair Growth and Disorders
- Osteoarthritis Treatment and Mechanisms
- Cytokine Signaling Pathways and Interactions
- Neuroendocrine Tumor Research Advances
- Urinary Tract Infections Management
- Neuroblastoma Research and Treatments
- Genetic and rare skin diseases.
- Natural product bioactivities and synthesis
- Surgical Sutures and Adhesives
- Urinary Bladder and Prostate Research
- Nonmelanoma Skin Cancer Studies
- Pelvic floor disorders treatments
- Cardiac Arrest and Resuscitation
- Alzheimer's disease research and treatments
- Body Contouring and Surgery
- Connexins and lens biology
- Bioactive Compounds and Antitumor Agents
- Cutaneous lymphoproliferative disorders research
- Vascular Malformations Diagnosis and Treatment
- Urticaria and Related Conditions
Prince Philip Dental Hospital
2025
University of Hong Kong
2024-2025
Southern Medical University
2022-2025
Tianjin Medical University Cancer Institute and Hospital
2025
Fudan University
2025
Wuhan University of Technology
2023-2024
Heilongjiang University of Chinese Medicine
2020-2024
National Central University
2018-2024
Hebei Normal University
2024
Target (United States)
2024
Pulmonary surfactant is a lipoprotein complex lining the alveolar surface to decrease tension and facilitate inspiration. Surfactant deficiency often seen in premature infants also children adults with respiratory distress syndrome. Mechanical stretch of type 2 epithelial (AT2) cells during lung expansion primary physiological factor that stimulates secretion; however, it unclear whether there mechanosensor dedicated for this process. Here we show loss mechanosensitive channels TMEM63A...
Bacterial infection, prolonged inflammation, and insufficient angiogenesis are the main challenges for effective wound repair. In this work, we developed a stretchable, remodeling, self-healing, antibacterial multifunctional composite hydrogel infected healing. The was prepared using tannic acid (TA) phenylboronic acid-modified gelatin (Gel-BA) through hydrogen bonding borate ester bonds incorporated iron-containing bioactive glasses (Fe-BGs) with uniform spherical morphologies amorphous...
Chronic diabetic wounds are the most common complication for patients. Due to high oxidative stress levels affecting entire healing process, treating remains a challenge. Here, we present strategy continuously regulating microenvironment by catalyst-like magnesium-gallate metal-organic framework (Mg-GA MOF) and developing sprayable hydrogel dressing with sodium alginate/chitosan quaternary ammonium salts treat wounds. Chitosan antibacterial properties can prevent bacterial infection. The...
Abstract Background and aim Post-traumatic osteoarthritis (PTOA) is a subtype of (OA). Exercise may produce release the myokine irisin through muscle fiber contraction. However, effect exercise-promoted production on internal interactions muscle–bone unit in PTOA studies remains unclear. Methods Eighteen 8-week-old Sprague–Dawley (SD) rats were randomly divided into three groups: Sham/sedentary (Sham/Sed), PTOA/sedentary (PTOA/Sed), PTOA/treadmill-walking (PTOA/TW). The model was established...
The major pathological mechanisms of osteoarthritis (OA) progression include inflammation, autophagy, and apoptosis, etc. Moderate mechanical strain exercise effectively improve chondrocyte degeneration by reducing these adverse factors. Mitofusin 2 (MFN2) is a crucial regulatory factor associated with autophagy its expression regulated exercise. This study aims to elucidate the effects moderate on MFN2 influence OA progression.Destabilization medial meniscus (DMM) surgery was performed rats...
Flower tea is widely loved as a drink, especially for the beautiful and rich flowers of orchid family, drying method different also unique. GC-MS used to study volatile substances determine quality flower teas. The findings show that freeze-drying can retain original aroma flavor Bletilla striata has highest sensory evaluation score, with key ethyl caproate N-heptanal containing 1.14% 6.28%, respectively, their ROAV values reaching 54.46 100.00. Additionally, well flavonoids,...
Abstract Non-small cell lung cancer (NSCLC) ranks as one of the leading causes cancer-related deaths worldwide. Despite prominence and effectiveness kinase-target therapies in NSCLC treatment, these drugs are suitable for beneficial to a mere ~30% patients. Consequently, need novel strategies addressing remains pressing. Deubiquitinases (DUBs), group diverse enzymes with well-defined catalytic sites that frequently overactivated cancers associated tumorigenesis regarded promising therapeutic...
Achieving a stable vasculature is crucial for tissue regeneration. Endothelial cells initiate vascular morphogenesis, followed by mural that stabilize new vessels. This study investigated the in vivo effects of Sema4D-Plexin-B1 signaling on stem from human exfoliated deciduous teeth (SHED)-supported angiogenesis, focusing its mechanism PDGF-BB secretion. We also explored macrophages as an endogenous source Sema4D stabilization. The Matrigel plug angiogenesis assay was conducted to examine...
Background Fruquintinib, a selective vascular endothelial growth factor receptor (VEGFR) inhibitor, has shown considerable efficacy in colorectal cancer (CRC) treatment. Despite its promising therapeutic effects, the precise molecular mechanisms underlying effects remain incompletely understood. In this study, we explored functional roles and of fruquintinib CRC therapy. Material methods Human cells (HCT-116 LOVO) were cultured treated with fruquintinib. Cell counting kit-8 assay kit (CCK-8)...
Aqueous-S batteries (ASBs) are emerging as promising energy storage technologies due to their high safety, low cost, and theoretical density. However, the present understanding of sulfur evolution in water relies on experience derived from conventional organic electrolyte-based (OSBs). The gap between ASB OSB has impeded progress advancing rational design catalysts aqueous phase. Herein, we reveal unique interaction H2O S species, which is fundamentally distinguishable counterparts. A series...
CRISPR system has been widely used due to its precision and versatility in gene editing. Un1Cas12f1 from uncultured archaeon (hereafter referred as Cas12f), known for compact size (529 aa), exhibits obvious delivery advantage editing vitro vivo. However, activity remains suboptimal. In this study, we engineer circular guide RNA (cgRNA) Cas12f significantly improve the efficiency of activation about 1.9–19.2-fold. When combined with a phase separation system, is further increased...