A5063263656- Immune Response and Inflammation
- Veterinary medicine and infectious diseases
- Cancer, Lipids, and Metabolism
- Gastric Cancer Management and Outcomes
- Helicobacter pylori-related gastroenterology studies
- Ferroptosis and cancer prognosis
- Colorectal Cancer Treatments and Studies
- Cancer, Hypoxia, and Metabolism
- Cancer Research and Treatments
- RNA modifications and cancer
- Ubiquitin and proteasome pathways
- Pancreatic and Hepatic Oncology Research
North China University of Science and Technology
2024-2025
Background Fruquintinib, a selective vascular endothelial growth factor receptor (VEGFR) inhibitor, has shown considerable efficacy in colorectal cancer (CRC) treatment. Despite its promising therapeutic effects, the precise molecular mechanisms underlying effects remain incompletely understood. In this study, we explored functional roles and of fruquintinib CRC therapy. Material methods Human cells (HCT-116 LOVO) were cultured treated with fruquintinib. Cell counting kit-8 assay kit (CCK-8)...
Abstract Background Colon cancer remains a major health concern worldwide, with genetic factors playing crucial role in its development. Toll-like receptors (TLRs) has been implicated various cancers, but their colon is not well understood. This study aims to identify functional polymorphisms the promoter and 3′UTR regions of TLRs evaluate association susceptibility. Methods We conducted case-control involving 410 patients healthy controls from Chinese population. Genotyping TLR3 , TLR4 TLR5...
Colorectal cancer is one of the most common malignant cancers. Pseudogenes have been identified as oncogenes or tumor suppressor genes in development various However, function pseudogene CSPG4P12 colorectal remains unclear. Therefore, aim this study was to investigate potential role and explore possible underlying mechanism. The difference expression between tissues adjacent normal analyzed using online Gene Expression Profiling Interactive Analysis 2 (GEPIA2) database. Cell viability colony...
Objective: To investigate the expression and significance of ubiquitin-specific proteases 2-69(USP2-69) in invasive ductal carcinoma breast. Methods: Twenty-four cases human breast tissue with diagnosed at Huanshan Hospital, Fudan University from 2013 to 2015 were collected, USP2-69 mRNA protein was detected by molecular hybridization, Western blot immunohistochemistry. over-expressed cultured cancer cell line MCF-7 plasmid transfection. The cellular proliferative activity investigated...