A5100684688- Viral-associated cancers and disorders
- Systemic Sclerosis and Related Diseases
- RNA modifications and cancer
- interferon and immune responses
- Cancer-related molecular mechanisms research
- Extracellular vesicles in disease
- CRISPR and Genetic Engineering
- Cancer-related gene regulation
- Ferroptosis and cancer prognosis
- Advanced biosensing and bioanalysis techniques
- Genetic Mapping and Diversity in Plants and Animals
- Head and Neck Cancer Studies
- Machine Learning in Bioinformatics
- Biomedical Text Mining and Ontologies
- RNA Research and Splicing
- Pluripotent Stem Cells Research
- Lymphoma Diagnosis and Treatment
- Cancer Mechanisms and Therapy
- RNA regulation and disease
- RNA Interference and Gene Delivery
- Cancer Cells and Metastasis
- Hippo pathway signaling and YAP/TAZ
- Bioinformatics and Genomic Networks
- Higher Education and Teaching Methods
- Mesenchymal stem cell research
Southern Medical University
2014-2025
Hangzhou Medical College
2025
Soochow University
2009-2025
Shanghai Agrobiological Gene Center
2023-2024
Ministry of Agriculture and Rural Affairs
2023-2024
Fujian Medical University
2022-2024
Yangpu Hospital of Tongji University
2015-2024
Second Affiliated Hospital of Nanchang University
2024
Nanchang University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2021
Abstract Summary We present a web server, GenCLiP 3, which is an updated version of 2.0 to enhance analysis human gene functions and regulatory networks, with the following improvements: (i) accurate recognition molecular interactions polarity directionality from entire PubMed database; (ii) support for Boolean search customize multiple-term quickly retrieve function-related genes; (iii) strengthened association between keyword by new scoring method; (iv) daily updates literature release at...
Autophagy is crucial for maintaining cellular energy homeostasis and cells to adapt nutrient deficiency, sensors regulating autophagy have been reported previously. However, the role of eiptranscriptomic modifications such as m6A in regulation starvation-induced unclear. Here, we show that reader YTHDF3 essential induction. modification up-regulated promote autophagosome formation lysosomal degradation upon deficiency. METTL3 depletion leads a loss functional inhibits YTHDF3-mediated flux....
Members of the nuclear receptor superfamily are thought to activate transcription by recruitment one or more recently identified coactivator complexes. Here we demonstrate that both peroxisome proliferator-activated binding protein (PBP) and steroid coactivator-1 (SRC-1) required for ligand-dependent transiently transfected chromosomally integrated reporter genes estrogen (ER) retinoic acid (RAR). To examine interactions between receptors specific coactivators in living cells, these proteins...
The heat shock protein 90 (HSP90) is overexpressed and highly associated with poor prognosis in many malignancies. However, the role of HSP90 gastric cancer has not been thoroughly elucidated. aim this study to investigate relationship expression clinicopathological parameters advanced cancer, estimate alteration after neoadjuvant chemotherapy. matrix metallopeptidase 9 (MMP-9) antigen was evaluated by immunohistochemistry 322 carcinoma samples. relationships between were analyzed. response...
Identifying biological functions and molecular networks in a gene list how the genes may relate to various topics is of considerable value biomedical researchers. Here, we present web-based text-mining server, GenCLiP 2.0, which can analyze human with enriched keywords interactions. Compared other similar tools, 2.0 offers two unique features: (i) analysis free terms (i.e. any literature) generated by literature mining or provided user (ii) accurate identification integration comprehensive...
Abstract Esophageal squamous cell carcinoma (ESCC) is one of the leading causes cancer-related death, especially in China. In addition, prognosis late stage patients extremely poor. However, biological significance long non-coding RNA lnc-ATB and its potential role ESCC remain to be documented. this study, we investigated underlying mechanism promoting oncogenic activity ESCC. Expression was higher tissues lines than that normal counterparts. Upregulated served as an independent predictor...
A recent study has demonstrated that the long non-coding RNA VPS9D1-AS1 is highly expressed in colorectal cancer and predicts poor prognosis. However, roles of gastric remained poorly understood.The aim this to decipher expression (GC) patients, so as assess whether or not it could be used a novel biomarker for prognosis patients.The was examined tissues paired adjacent non-tumorous from 126 patients using qRT-PCR. Correlations between clinicopathological parameters patients' survival were...
To explore the incidence of workplace violence against nurses in Chinese hospitals.Previous systematic reviews on health care workers did not include many articles published Chinese. Although several studies have investigated cases providers China, no meta-analysis has been conducted to assess nurses.In this study, relevant data were retrieved from up July 2020. A was using R software (Version 4.0).The 12-month among 71% (95% CI 67%-75%), and verbal most common sub-type (63%, 95%...
Abstract Background The CRISPR/Cas12a and CRISPR/Cas13d systems are widely used for fundamental research hold great potential future clinical applications. However, the short half-life of guide RNAs (gRNAs), particularly free gRNAs without Cas nuclease binding, limits their editing efficiency durability. Results Here, we engineer circular (cgRNAs) to increase stability, thus availability Cas12a Cas13d processing loading, boost editing. cgRNAs increases Cas12a-based transcription activators...
Genetic manipulation has proven valuable in identifying the role of specific genes cellular function. Genomic disruption that are expressed during embryonic development or multiple tissue types, however, complicates phenotypic analysis. We demonstrate targeted expression an inhibitor peptide derived from myosin light chain kinase can neutralize function calmodulin. have shown elimination nuclear Ca2+-calmodulin causes structure. Targeted this calmodulin gene lung epithelium transgenic mice...
// Jia-Hong Wang 1, * , Hong-sheng Tang Xiao-Shan Li 2, Xiang-Liang Zhang 1 Xian-Zi Yang Li-Si Zeng Qiang Ruan Yong-Hong Huang Gao-Jie Liu Jin ** and Shu-Zhong Cui Department of Abdominal Surgery, Affiliated Cancer Hospital & Institute Guangzhou Medical University, Guangzhou, 510095, Guangdong, China 2 Oncology, These authors have contributed equally to this work jointly supervised Correspondence to: Cui, email: cuishuzhong@126.com Wang, gdwjin@126.com Keywords: FOXO6, gastric cancer,...
Poor cell survival and limited functional benefits have restricted mesenchymal stem (MSC) efficacy for treating myocardial infarction (MI), suggesting that a better understanding of biology is needed. The transcription factor HIF-2α an essential regulator the transcriptional response to hypoxia, which can interact with embryonic cells (ESCs) Oct4 modulate its signaling. Here, we obtained very small embryonic-like (vselMSCs) from MI patients, possessed cells' (VSELs) morphology as well ESCs'...
Accumulating evidence indicates that immunotherapy helped to improve the survival and quality-of-life of patients with lung adenocarcinoma (LUAD) or squamous cell carcinoma (LUSC) besides chemotherapy gene targeting treatment. This study aimed develop immune-related signatures in LUAD LUSC subtypes, respectively. samples were divided into high- low-abundance groups immune infiltration (Immunity_H Immunity_L) based on abundance infiltrations. The distribution cells was significantly different...
<p>S2. There is no significant difference in endothelial apoptosis-associated proteins between nontumor tissues and NPC metastatic tissues.</p>
<p>S3. Identification of exosomes.</p>
<p>S8. Exosomes derived from NPC cells increase pyroptosis and vascular permeability in pulmonary hepatic endothelial of mice.</p>
<p>S5. Exosomes derived from NPC cells induce endothelial cell death.</p>
<p>S4. NPC serum exosomes induce endothelial cell proptosis.</p>
<div>Abstract<p>Extravasation is a key step in tumor metastasis. Epstein‒Barr virus plays crucial role nasopharyngeal carcinoma (NPC) However, the functions and molecular mechanisms of during cell extravasation remain unclear. Here, we showed that expression pyroptosis-associated proteins greater endothelial cells metastatic NPC tissues than those nontumor exosomes derived from promoted pyroptosis, vascular permeability, extravasation. Moreover, found BART2-5p abundant serum...
<p>S7. Exosomes derived from NPC cells increase vascular permeability.</p>
<p>S1. There is no significant difference in endothelial pyroptosis-associated proteins between nontumor nasopharyngeal tissues and primary NPC tissues.</p>
<p>S6. Detection of EBV in EBV-cleared or EBV-infected NPC cells.</p>
<p>Information for Supplementary Figure</p>
Background Stem cell therapy shows promise for treating skin diseases and enhancing medical aesthetics. However, safety data subcutaneous injection of stem cells remain limited. In this study, we evaluated the toxicity human umbilical cord mesenchymal (hUC-MSCs) in NOD. Cg-Prkdc scid IL2rg tm1Sug /JicCrl (NOG) mice. Methods Mice received hUC-MSC injections at doses 2.5 × 10 7 2.0 8 cells/kg on days 1, 8, 12, 16, 20, followed by withdrawal observation 6 weeks. Toxicity was assessed through...