A5075738198- interferon and immune responses
- RNA modifications and cancer
- Extracellular vesicles in disease
- Cancer-related molecular mechanisms research
- COVID-19 Clinical Research Studies
- Cardiac Ischemia and Reperfusion
- Viral-associated cancers and disorders
- Cell death mechanisms and regulation
- Hormonal Regulation and Hypertension
- Acupuncture Treatment Research Studies
- Inflammasome and immune disorders
- Traditional Chinese Medicine Studies
- Mosquito-borne diseases and control
- Trace Elements in Health
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Blood Pressure and Hypertension Studies
- Cancer, Lipids, and Metabolism
- Parvovirus B19 Infection Studies
- Mitochondrial Function and Pathology
- SARS-CoV-2 and COVID-19 Research
- COVID-19 and healthcare impacts
- Radioactive element chemistry and processing
- Sodium Intake and Health
- Vitamin C and Antioxidants Research
- Plant-based Medicinal Research
Public Health Clinical Center of Chengdu
2020-2025
Shaanxi Provincial Hospital of Traditional Chinese Medicine
2021-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2020
Nanjing Agricultural University
2018
The coronavirus disease 2019 (COVID-19) epidemic has been almost controlled in China under a series of policies, including "early diagnosis and early treatment". This study aimed to explore the association between treatment with Qingfei Paidu decoction (QFPDD) favorable clinical outcomes. In this retrospective multicenter study, we included 782 patients (males, 56 %; median age 46) confirmed COVID-19 from 54 hospitals nine provinces China, who were divided into four groups according...
<p>S2. There is no significant difference in endothelial apoptosis-associated proteins between nontumor tissues and NPC metastatic tissues.</p>
<p>S3. Identification of exosomes.</p>
<p>S8. Exosomes derived from NPC cells increase pyroptosis and vascular permeability in pulmonary hepatic endothelial of mice.</p>
<p>S5. Exosomes derived from NPC cells induce endothelial cell death.</p>
<p>S4. NPC serum exosomes induce endothelial cell proptosis.</p>
<div>Abstract<p>Extravasation is a key step in tumor metastasis. Epstein‒Barr virus plays crucial role nasopharyngeal carcinoma (NPC) However, the functions and molecular mechanisms of during cell extravasation remain unclear. Here, we showed that expression pyroptosis-associated proteins greater endothelial cells metastatic NPC tissues than those nontumor exosomes derived from promoted pyroptosis, vascular permeability, extravasation. Moreover, found BART2-5p abundant serum...
<p>S7. Exosomes derived from NPC cells increase vascular permeability.</p>
<p>S1. There is no significant difference in endothelial pyroptosis-associated proteins between nontumor nasopharyngeal tissues and primary NPC tissues.</p>
<p>S6. Detection of EBV in EBV-cleared or EBV-infected NPC cells.</p>
<p>Information for Supplementary Figure</p>
Background: Qingfei Paidu decoction (QFPDD) has been widely used in treating coronavirus disease 2019 (COVID-19) China. However, studies on the treatment effect of COVID-19 patients and other respiratory diseases have not well demonstrated. Our study aims to determine QFPDD combination with conventional diseases. Methods: This retrospective recruited who were treated for at least two courses (6 days) from seven hospitals five provinces January 21 March 18 2020. Demographic, epidemiological,...
Liver cirrhosis affects the structures and physiological functions of intestine. Our previous study revealed that liver injury inhibited 25-hydroxylation vitamin D (25(OH)-VD). The aim this was to investigate roles mechanisms in cirrhosis-induced intestinal injury. rat model established through administration carbon tetrachloride (CCl4) for 8 weeks. Hematoxylin-eosin staining performed unveil induced by cirrhosis. Enzyme-linked immunosorbent reverse transcription PCR (RT-PCR) analysis were...
BackgroundInvestigations into the role of traditional Chinese medicine (TCM) pharmacotherapy in early stage COVID-19 pandemic real clinical circumstances are necessary as we reflect on past. PurposeTo observe effectiveness TCM real-world outcomes patients during surges SARS-CoV-2 alpha and delta variants. MethodsA retrospective cohort design was used. Data collected from 9 sites across mainland China. 2021 confirmed admitted between January 1, 2020 17, 2022 were screened for inclusion....
Abstract Extravasation is a key step in tumor metastasis. Epstein‒Barr virus (EBV) plays crucial role nasopharyngeal carcinoma (NPC) However, the functions and molecular mechanisms of EBV during cell extravasation remains unclear. Here, we showed that expression pyroptosis-associated proteins greater endothelial cells metastatic NPC tissues than those nontumor Exosomes derived from promoted pyroptosis, vascular permeability, extravasation. Moreover, found BART2-5p abundant serum exosomes...
Abstract The resumption of coronary artery blood supply is often accompanied by myocardial ischemia/reperfusion (I/R) injury after the occurrence infarction, shock, cardiac surgery and other events. Metallothionein-2A (MT2A) has functions scavenging free radicals, anti-oxidative stress, anti-apoptosis, anti-autophagy, promoting vascular growth. activation p38 MAPK pathway can induce cardiomyocyte apoptosis in H9c2 cardiomyocytes during I/R, thereby aggravating I/R injury. However, it not...
Objective To investigate the role of pigment epithelium-derived factor (PEDF) and metallothionein 2A (MT2A) in hypoxia-induced myocardial cell injury. Methods 20 healthy C57 B/6 mice were randomly divided into 4 groups. The cells isolated by enzyme digestion. After treatment with MT2A, group A was cultured under normoxia (95% air+ 5% CO2) , whereas groups B, C D hypoxia (94% N2+1% O2+5% . PEDF-MT2A overexpressed C, expression blocked siRNA. level reactive oxygen species (ROS)...
Background: Few studies have examined the association between treatment given time and clinical outcomes, which is indeed of great importance to management coronavirus disease 2019 (COVID-19). We performed this study explore whether early brings favorable outcomes. Methods: In retrospective multicenter study, we included patients aged 18 87 years with confirmed COVID-19 on admission from 54 hospitals in nine provinces China 21 January 10 March, 2020. Final date follow-up was March 17, All...
Abstract Background Urine albumin/creatinine ratio (UACR) is an important marker of early renal damage (ERD) caused by hypertension. Recent studies showed that blood pressure was a significant inverse association with temperature and climate. The purposes our study were sought to explore the common medical comorbidities ERD, find independent risk factors ERD in Chinese tropics essential Methods From January 2018 December 2019, we assessed UACR total 599 hypertensive Hainan patients. We...