A5103280799- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- Asthma and respiratory diseases
- Antibiotic Resistance in Bacteria
- Enterobacteriaceae and Cronobacter Research
- COVID-19 diagnosis using AI
- Inflammasome and immune disorders
- Pediatric health and respiratory diseases
- Tuberculosis Research and Epidemiology
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Disaster Response and Management
- COVID-19 and Mental Health
- Mycobacterium research and diagnosis
- Neonatal Respiratory Health Research
- SARS-CoV-2 detection and testing
- Clinical Laboratory Practices and Quality Control
- Chemotherapy-induced cardiotoxicity and mitigation
- COVID-19 and healthcare impacts
- Virus-based gene therapy research
- Advanced Battery Materials and Technologies
- Pharmacological Receptor Mechanisms and Effects
- Infectious Encephalopathies and Encephalitis
- IL-33, ST2, and ILC Pathways
- Histone Deacetylase Inhibitors Research
Fujian Normal University
2025
University of British Columbia
2024
Wuhan University
2023
The People's Hospital of Guangxi Zhuang Autonomous Region
2020-2022
Fifth Affiliated Hospital of Sun Yat-sen University
2010-2022
Sun Yat-sen University
2010-2022
Huazhong University of Science and Technology
2016-2022
Guiyang Medical University
2022
Mercy Health
2022
Tongji Hospital
2016-2022
Abstract Objective This study investigated the influence of Coronavirus Disease 2019 (COVID-19) on lung function in early convalescence phase. Methods A retrospective COVID-19 patients at Fifth Affiliated Hospital Sun Yat-sen University were conducted, with serial assessments including volumes (TLC), spirometry (FVC, FEV1), diffusing capacity for carbon monoxide (DLCO),respiratory muscle strength, 6-min walking distance (6MWD) and high resolution CT being collected 30 days after discharged....
Abstract Background To illustrate the extent of transmission, identify affecting risk factors and estimate epidemiological modeling parameters severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in household setting. Methods We enrolled 35 confirmed index cases their 148 contacts, January 2020–February 2020, Zhuhai, China. All participants were interviewed asked to complete questionnaires. Household contacts then prospectively followed active symptom monitoring through 21-day period...
Abstract The new coronavirus (SARS-CoV-2) outbreak originating from Wuhan, China, poses a threat to global health. While it’s evident that the virus invades respiratory tract and transmits human through airway, other viral tropisms transmission routes remain unknown. We tested RNA in stool 73 SARS-CoV-2-infected hospitalized patients using rRT-PCR. 53.42% of positive stool. 23.29% remained feces even after decreased undetectable level tract. was also detected gastrointestinal tissues....
The coronavirus disease 2019 (COVID-19) epidemic has been almost controlled in China under a series of policies, including "early diagnosis and early treatment". This study aimed to explore the association between treatment with Qingfei Paidu decoction (QFPDD) favorable clinical outcomes. In this retrospective multicenter study, we included 782 patients (males, 56 %; median age 46) confirmed COVID-19 from 54 hospitals nine provinces China, who were divided into four groups according...
Abstract Objective: This study investigated the influence of Coronavirus Disease 2019 (COVID-19) on lung function in early convalescence phase. Methods: A prospective COVID-19 patients at Fifth Affiliated Hospital Sun Yat-sen University were conducted, with serial assessments including volumes (TLC), spirometry (FVC, FEV1), diffusing capacity for carbon monoxide (DLCO),respiratory muscle strength, 6-minute walking distance (6MWD) and high resolution CT being collected 30 days after...
The presence and molecular characteristics of carbapenemase-producing Enterobacteriaceae (CPE) among meat products in China were investigated. A total 110 carbapenem-resistant (CRE) isolates, including 94 Escherichia coli 10 Klebsiella pneumoniae identified from 105 794 (13.2%) samples. positive rates markedly increased 2016 (9.4%) to 2018 (22.2%). Only blaNDM genes detected; 79.1% carried by IncX3 plasmids. Routine monitoring the animal food supply is highly recommended.
Our aim in this study was to identify a prognostic biomarker predict the disease prognosis and reduce mortality rate of coronavirus 2019 (COVID-19), which has caused worldwide pandemic.COVID-19 patients were randomly divided into training test groups. Univariate multivariate Cox regression analyses performed signature, selected establish risk model group. The signature COVID-19 validated group.The combined with following 5 indicators: neutrophil count, lymphocyte procalcitonin, age,...
An important limitation of the T-SPOT(®).TB assay is its inability to distinguish active tuberculosis (TB) from latent tuberculous infection (LTBI).We proposed a new calculation method for T-SPOT and assessed effect on distinguishing TB LTBI.A total 162 patients 97 LTBI individuals were diagnosed according conventional tests assay.The results early secreted antigenic target 6 (ESAT-6) culture filtrate protein 10 (CFP-10) in cannot be recommended LTBI. The number phytohaemagglutinin (PHA)...
Abstract Background COVID-19 is a new and highly contagious respiratory disease that has caused global spread, high case fatality rate in severe patients, huge medical burden due to invasive mechanical ventilation. The current diagnosis treatment guidelines are still need be improved, more excellent clinical experience needed provide reference. Methods We analyzed summarized data of 97 confirmed adult patients (including 26 cases) admitted the Fifth Affiliated Hospital Sun Yat-sen University...
Bloodstream infection (BSI) caused by carbapenem-resistant Enterobacteriaceae are potentially life-threatening related to poorer outcomes. Colistin is considered one of the last-resort treatments against human infections multidrug-resistant (MDR) Gram-negative bacteria. Therefore, emergence strains from blood that co-harboring mcr and carbapenem resistance genes were as a serious problem.In this study, two mcr-9-harboring MDR Enterobacter cloacae isolates BSI034 BSI072 recovered BSI patients...
Introduction. Magnesium (Mg) administration has been shown to promote bronchodilation and improve lung function in asthma. It also plays an additional role modulating the immune responses. This study was initiated explore if Mg supplementation could affect secretion of cytokines acute asthmatic CD4+ T cells. Methods. Total serum concentrations patients healthy controls were determined. cells isolated from blood patients. They cultured various Mg-supplemented (0.8, 5, 10, 15, 20 mmol/l)...
Deaths attributed to Coronavirus Disease 2019 (COVID-19) are mainly due severe hypoxemic respiratory failure. Although the inflammatory storm has been considered main pathogenesis of COVID-19, hypersensitivity may be another important mechanism involved in cases, which have a perfect response corticosteroids (CS).We detected serum level anti-SARS-CoV-2-spike S1 protein-specific IgE (SP-IgE) and anti-SARS-CoV-2 nucleocapsid (NP-IgE) COVID-19. Correlation levels specific clinical severity were...
Background: Qingfei Paidu decoction (QFPDD) has been widely used in treating coronavirus disease 2019 (COVID-19) China. However, studies on the treatment effect of COVID-19 patients and other respiratory diseases have not well demonstrated. Our study aims to determine QFPDD combination with conventional diseases. Methods: This retrospective recruited who were treated for at least two courses (6 days) from seven hospitals five provinces January 21 March 18 2020. Demographic, epidemiological,...
Background A worldwide outbreak of coronavirus disease (COVID-19), since 2019, has brought a disaster to people all over the world. Many researchers carried out clinical epidemiological studies on patients with COVID-19 previously, but risk factors for different levels severity are still unclear. Methods 562 laboratory-confirmed from 12 hospitals in China were included this retrospective study. Related information, therapies, and imaging data extracted electronic medical records compared...
We established an aptamer fluorescence microscopy approach for rapid detection of MTB in clinical sputum samples. The use probes was proven to significantly increase the sensitivity smear microscopy.
Abstract Background There is an urgent need for accurate, rapid, inexpensive biomarkers that can differentiate coronavirus disease 2019 (COVID-19) from bacterial pneumonia. We assess the role of ferritin-to-procalcitonin (F/P) ratio to classify pneumonia cases into those due COVID-19 vs pathogens. Methods This multicenter case–control study compared patients with pneumonia, admitted between March 1 and May 31, 2020. Patients co-infection were excluded. The F/P in compared. Receiver operating...
Impulse oscillometry (IOS) can be used to evaluate airway impedance in patients with obstructive diseases. Previous studies have demonstrated that IOS parameters differ between bronchiectasis and healthy controls. This study aims explore the usefulness of assessing disease severity reversibility bronchiectasis.Seventy-four non-cystic fibrosis who visited our Respiratory Medicine outpatient clinic were consecutively recruited. Spirometry, plethysmography tests performed. Patients stratified...
Context Aidi injection (ADI), a traditional Chinese medicine antitumor injection, is usually combined with doxorubicin (DOX) for the treatment of malignant tumours. The cardiotoxicity DOX ameliorated by ADI in clinic. However, relevant mechanism unknown.Objective To investigate effects on DOX-induced and its mechanism.Materials methods ICR mice were randomly divided into six groups: control, ADI-L, ADI-H, DOX, + ADI-L ADI-H. (i.p., 0.03 mg/10 g) was administered presence or absence 0.1 0.2...
Background. Coronavirus disease 2019 (COVID-19) has been a global threat that pushes healthcare to its limits. Hypertension is one of the most common risk factors for cardiovascular complications in COVID-19 and strongly associated with severity mortality. To date, clinical mechanisms by which hypertension leads increased are still unclear. Furthermore, additional might increase these risks, such as consideration age sex, interest when search personalized treatments hypertensive patients....
There is a need to develop tools differentiate COVID-19 from bacterial pneumonia at the time of clinical presentation before diagnostic testing available. To determine if Ferritin-to-Procalcitonin ratio (F/P) can be used pneumonia. This case-control study compared patients with either or pneumonia, admitted between March 1 and May 31, 2020. Patients co-infection were excluded. A multicenter conducted three hospitals that included UCHealth Phoebe Putney Memorial Hospital in United States,...