A5100375134- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- Eosinophilic Esophagitis
- IL-33, ST2, and ILC Pathways
- Cystic Fibrosis Research Advances
- COVID-19 diagnosis using AI
- Pediatric health and respiratory diseases
- Complement system in diseases
- Head and Neck Surgical Oncology
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neonatal Respiratory Health Research
- Recycling and Waste Management Techniques
- Healthcare professionals’ stress and burnout
- Respiratory Support and Mechanisms
- Respiratory viral infections research
- Microplastics and Plastic Pollution
- COVID-19 and Mental Health
- SARS-CoV-2 detection and testing
- Mycobacterium research and diagnosis
- Effects and risks of endocrine disrupting chemicals
- Pharmacological Receptor Mechanisms and Effects
- Sodium Intake and Health
- Sepsis Diagnosis and Treatment
- Machine Learning in Healthcare
Sun Yat-sen University
2020-2025
Fifth Affiliated Hospital of Sun Yat-sen University
2020-2025
University of Arizona
2024
Ningxia Medical University General Hospital
2020
Ningxia Medical University
2020
National University of Singapore
2014
China Medical University
2006
Abstract Objective This study investigated the influence of Coronavirus Disease 2019 (COVID-19) on lung function in early convalescence phase. Methods A retrospective COVID-19 patients at Fifth Affiliated Hospital Sun Yat-sen University were conducted, with serial assessments including volumes (TLC), spirometry (FVC, FEV1), diffusing capacity for carbon monoxide (DLCO),respiratory muscle strength, 6-min walking distance (6MWD) and high resolution CT being collected 30 days after discharged....
Abstract The new coronavirus (SARS-CoV-2) outbreak originating from Wuhan, China, poses a threat to global health. While it’s evident that the virus invades respiratory tract and transmits human through airway, other viral tropisms transmission routes remain unknown. We tested RNA in stool 73 SARS-CoV-2-infected hospitalized patients using rRT-PCR. 53.42% of positive stool. 23.29% remained feces even after decreased undetectable level tract. was also detected gastrointestinal tissues....
Effective therapies are urgently needed for the SARS-CoV-2 pandemic. Chloroquine has been proved to have antiviral effect against coronavirus in vitro. In this study, we aimed assess efficacy and safety of chloroquine with different doses COVID-19. multicenter prospective observational enrolled patients older than 18 years old confirmed infection excluding critical cases from 12 hospitals Guangdong Hubei Provinces. Eligible received phosphate 500 mg, orally, once (half dose) or twice (full...
Abstract Although human antibodies elicited by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleocapsid (N) protein are profoundly boosted upon infection, little is known about function of N-reactive antibodies. Herein, we isolate and profile a panel 32 N protein-specific monoclonal (mAbs) from quick recovery disease-19 (COVID-19) convalescent patient who has dominant antibody responses to SARS-CoV-2 rather than spike (S) protein. The complex structure RNA binding domain...
To investigate the relation of smoking and microplastic inhalation, we conducted a prospective study combining population-based experimental work. Bronchoalveolar lavage fluid (BALF) samples from 17 smokers 15 nonsmokers were collected in Zhuhai City, China. We simulated an active model to explore contribution inhaled microplastics. The characteristics microplastics BALF cigarette smoke determined using laser direct infrared spectroscopy. compared differences between as well control groups....
Microplastics (MPs) have received a lot of attention and been detected in multiple environmental matrices as new hazard, but studies on human internal exposure to MPs are limited. Here, we collected lung tissue samples from 12 nonsmoking patients evaluate the characteristics tissues using an Agilent 8700 laser infrared imaging spectrometer scanning electron microscopy. We 108 covering types samples, with median concentration 2.19 particles/g. Most (88.89%) were sized between 20 100 μm....
Abstract Objective: This study investigated the influence of Coronavirus Disease 2019 (COVID-19) on lung function in early convalescence phase. Methods: A prospective COVID-19 patients at Fifth Affiliated Hospital Sun Yat-sen University were conducted, with serial assessments including volumes (TLC), spirometry (FVC, FEV1), diffusing capacity for carbon monoxide (DLCO),respiratory muscle strength, 6-minute walking distance (6MWD) and high resolution CT being collected 30 days after...
Abstract Background Effective therapies are urgently needed for the SARS-CoV-2 pandemic. Chloroquine has been proved to have antiviral effect against coronavirus in vitro. In this study, we aimed assess efficacy and safety of chloroquine with different doses COVID-19. Method multicenter prospective observational enrolled patients older than 18 years old confirmed infection excluding critical cases from 12 hospitals Guangdong Hubei Provinces. Eligible received phosphate 500mg, orally, once...
Tropheryma whipplei is the bacterium associated with Whipple’s disease (WD), a chronic systemic infectious primarily involving gastrointestinal tract. T. can also be detected in different body site of healthy individuals, including saliva and feces. Traditionally, has higher prevalence bronchoalveolar lavage fluid (BALF) immunocompromised individuals. Few studies have explored significance detection BALF. Herein, we retrospectively reviewed 1725 BALF samples which for metagenomic...
Type 2 innate lymphoid cells (ILC2s) are essential for maintaining immune regulation and promoting tissue homeostasis in allergic asthma. How the development of gut microbiota on neonatal ILC2s influences airway inflammation remains unclear. Here we focus offspring ILC2 context alterations maternal microbiota. C57BL/6 mice were gavaged with OM-85 during pregnancy and/or lactation, ILC2-driven OVA-sensitized adult was observed. early life investigated using recombinant (r)IL-33, rIL-25...
Abstract Background COVID-19 is a new and highly contagious respiratory disease that has caused global spread, high case fatality rate in severe patients, huge medical burden due to invasive mechanical ventilation. The current diagnosis treatment guidelines are still need be improved, more excellent clinical experience needed provide reference. Methods We analyzed summarized data of 97 confirmed adult patients (including 26 cases) admitted the Fifth Affiliated Hospital Sun Yat-sen University...
COVID-19 has raised worldwide concern as spiraling into a pandemic. Reports about comprehensive investigation of viremia are extremely scanty. Herein, we present four patients with positive SARS-CoV-2 nucleic acid test in blood, accounting for 12.12% 33 detected cases. Rapid deterioration these cases septic shock, accompanying lung CT images enlarged rapidly, decrease blood oxygen, heart rate drop (with asynchrony hypoxemia) accompanied viremia. It indicates that massive replication and...
Deaths attributed to Coronavirus Disease 2019 (COVID-19) are mainly due severe hypoxemic respiratory failure. Although the inflammatory storm has been considered main pathogenesis of COVID-19, hypersensitivity may be another important mechanism involved in cases, which have a perfect response corticosteroids (CS).We detected serum level anti-SARS-CoV-2-spike S1 protein-specific IgE (SP-IgE) and anti-SARS-CoV-2 nucleocapsid (NP-IgE) COVID-19. Correlation levels specific clinical severity were...
Impulse oscillometry (IOS) can be used to evaluate airway impedance in patients with obstructive diseases. Previous studies have demonstrated that IOS parameters differ between bronchiectasis and healthy controls. This study aims explore the usefulness of assessing disease severity reversibility bronchiectasis.Seventy-four non-cystic fibrosis who visited our Respiratory Medicine outpatient clinic were consecutively recruited. Spirometry, plethysmography tests performed. Patients stratified...
Interleukin-33 (IL-33) exacerbates asthma probably through type 2 innate lymphoid cells (ILC2s). Nevertheless, the association between eosinophilic (EA) and ILC2s remains obscure, mechanisms by which IL-33 affects are yet to be clarified.
COVID-19 is a highly contagious respiratory disease caused by the SARS-CoV-2 virus. Patients with severe have high fatality rate and face huge medical burden due to need for invasive mechanical ventilation. Hypoxic failure major cause of death in these patients. There are currently no specific anti-SARS-CoV-2 drugs, effect corticosteroids still controversial.The clinical data 102 patients, including 27 patients disease, were analyzed. The serum levels total IgE compared healthy controls...
Abstract Objective : This study investigated the influence of Coronavirus Disease 2019 (COVID-19) on lung function in early convalescence phase. Methods A prospective retrospective COVID-19 patients at Fifth Affiliated Hospital Sun Yat-sen University were conducted, with serial assessments including volumes (TLC), spirometry (FVC, FEV1), diffusing capacity for carbon monoxide (DLCO),respiratory muscle strength, 6-minute walking distance (6MWD) and high resolution CT being collected 30 days...
Hypertension is a leading risk factor for disease burden and death worldwide. Several organ systems are involved in the development of hypertension, which contributes to stroke, heart disease, kidney disease. Despite broad health relevance, our understanding molecular landscape hypertension limited lags other major diseases. Here we report an extensive analysis its end-organ damage uncover novel mechanisms linking human genetic variants these We obtained single-nucleus RNA-seq (612,984...
The outbreak of SARS-CoV-2 lead to a worldwide pandemic which poses substantial challenges public health.We enrolled 102 consecutive recovered patients with laboratory-confirmed infection. Epidemiological and demographic characteristics, temporal dynamic profiles laboratory tests findings on chest CT radiography, clinical outcomes were collected analyzed.Independent risk factors for prolonged fever, viral RNA shedding or radiologic recovery included age more than 44 years, female gender,...