A5101995518- HIV/AIDS drug development and treatment
- Toxic Organic Pollutants Impact
- Carcinogens and Genotoxicity Assessment
- Hepatitis C virus research
- Pesticide Exposure and Toxicity
- HIV Research and Treatment
- Mosquito-borne diseases and control
- Immune Cell Function and Interaction
- Per- and polyfluoroalkyl substances research
- COVID-19 Clinical Research Studies
- Hepatitis B Virus Studies
- Phytochemical Studies and Bioactivities
- Leptospirosis research and findings
- CNS Lymphoma Diagnosis and Treatment
- Viral Infections and Vectors
- Phytochemistry and Bioactive Compounds
- Scoliosis diagnosis and treatment
- MicroRNA in disease regulation
- Galectins and Cancer Biology
- Sirtuins and Resveratrol in Medicine
- Acute Lymphoblastic Leukemia research
- Veterinary medicine and infectious diseases
- Renal Diseases and Glomerulopathies
- Aquaculture disease management and microbiota
- Vector-borne infectious diseases
Fifth Affiliated Hospital of Sun Yat-sen University
2009-2024
Sun Yat-sen University
2009-2024
Dalian Medical University
2015-2022
Chinese People's Liberation Army
2020-2021
Beijing University of Chinese Medicine
2015
Hangzhou Academy of Agricultural Sciences
2013
BackgroundCorona Virus Disease 2019 (COVID-19) due to the novel coronavirus (SARS-CoV-2) emerged in Wuhan city and rapidly spread throughout China. We aimed compare arbidol lopinavir/ritonavir(LPV/r) treatment for patients with COVID-19 LPV/r only.MethodsIn this retrospective cohort study, we included adults (age≥18years) laboratory-confirmed without Invasive ventilation, diagnosed between Jan 17, 2020, Feb 13, 2020. Patients, after were given oral combination group only monotherapy 5–21...
Abstract The new coronavirus (SARS-CoV-2) outbreak originating from Wuhan, China, poses a threat to global health. While it’s evident that the virus invades respiratory tract and transmits human through airway, other viral tropisms transmission routes remain unknown. We tested RNA in stool 73 SARS-CoV-2-infected hospitalized patients using rRT-PCR. 53.42% of positive stool. 23.29% remained feces even after decreased undetectable level tract. was also detected gastrointestinal tissues....
Q fever is a worldwide zoonosis caused by Coxiella burnetii (Cb). From January 2018 to November 2019, plasma samples from 2,382 patients with acute of unknown cause at hospital in Zhuhai city China were tested using metagenomic next-generation sequencing (mNGS). Of those tested, 138 (5.8%) diagnosed based on the presence Cb genomic DNA detected mNGS. Among these, 78 cases (56.5%) presented Nov Mar suggesting an outbreak fever. 55 detailed clinical information that occurred during period used...
Household pesticide exposure during pregnancy has been associated with a more than 2-fold increased risk in infant leukemia, and chlorpyrifos (CPF) is among the most frequently applied insecticides. During early fetal development, liver hematopoietic organ majority of cells being CD34+ stem (CD34+HSC). The utero injury to CD34+HSC known underlie pathogenesis several blood disorders, often involving rearrangements mixed-lineage leukemia (MLL) gene on 11q23. In this study, we evaluated...
Increased energy intake and reduced physical activity can lead to obesity, diabetes metabolic syndrome. Transcriptional modulation of networks has become a focus current drug discovery research into the prevention treatment disorders associated with surplus obesity. Tang-Nai-Kang (TNK), mixture five herbal plant extracts, been shown improve abnormal glucose metabolism in patients pre-diabetes. Here, we report phenotype SHR.Cg-Leprcp/NDmcr (SHR/cp) rats treated TNK. Pre-diabetic SHR/cp were...
Abstract Respiratory state analysis based on respiratory strain monitoring plays an increasingly important role in the assessment of continuous dynamic physiological human body. The proposed system uses STM32F411 single-chip microcomputer as main control chip, combined with FDC2214 capacitor-to-digital converter, collects capacitance value flexible cloth-based capacitive sensor through IIC method, and sends collected result to upper computer for processing Bluetooth. device signal chest...
Concerns regarding potential toxicity and drug-drug interactions during long-term treatment with three-drug active antiretroviral therapy (ART) regimens have been attracting increasing attention. We aimed to evaluate the efficacy safety of dolutegravir (DTG) plus lamivudine (3TC) in ART-naive adults China.This prospective observational cohort study enrolled HIV-naive inpatients treated DTG + 3TC (2DR arm) or efavirenz (EFV) tenofovir disoproxil fumarate (TDF) (3DR arm). There were no limits...
Aims . This study aimed to investigate miR-106a expression in peripheral blood mononuclear cells (PBMCs) of chronic hepatitis B (CHB) patients and analyze the function miR-106a. Materials Methods levels PBMCs from 40 healthy controls 56 CHB were analyzed by quantitative real-time polymerase chain reaction (qRT-PCR). The luciferase activity assays used determine whether binds 3′UTR IL-8. mimics inhibitors transfected into PBMCs. IL-8 mRNA protein detected determined qRT-PCR ELISA,...
Mucosal associated invariant T (MAIT) cells play a critical role in Helicobacter pylori (H. pylori)-induced gastritis by promoting mucosal inflammation and aggravating injuries (1, 2). However, the underlying mechanism key molecules involved are still uncertain. Here we identified OX40, co-stimulatory molecule mainly expressed on cells, as regulator to promote proliferation IL-9 production MAIT facilitate H. pylori-positive patients. Serum examination revealed an increased level of...
Hepatitis C virus (HCV) infection is a leading cause of hepatoma worldwide. HCV classified into seven major genotypes, and genotype 6 commonly prevalent in Asia. An efficient infectious culture system representative isolates that are currently important for research. Here, we developed robust cell 6a clinical isolate CH6a using novel strategy. Initially, determined consensus sequence patient serum, assembled full-length recombinant the overlapped PCR-derived clones shared high homology with...
Aeromonas dhakensis is an important ubiquitous Gram-negative and freshwater bacterium detected in different reservoirs. It can cause invasive diseases humans. Herein, we report the first case Mainland China of a fulminant death 29-year-old man as result new, unexpected association between septicemic A. hepatitis B viral infection (HBV). patient died from multiple organ failure 5 d postadmission after ingestion Snakehead Fish meal. The isolated was initially misidentified hydrophila using...
CD103 is considered as a surface marker for the resident immune cells. However, little known about intrinsic function of in infection and inflammation. In this study, we found that was highly expressed CD4+T cells gastric mucosa from patients with H. pylori-positive gastritis. Mucosal CD103+CD4+T exhibited an increase CD45RO+CCR7– effector memory phenotype high expression chemokine receptors CXCR3 CCR9 compared those CD103—CD4+T An vitro coculture study demonstrated H.pylori-specific antigen...
Weil’s disease, an icterohemorrhagic infection, is the most severe and fatal form of leptospirosis characterized by jaundice, renal dysfunction, hemorrhagic predisposition. disease with HIV infection has rarely been reported. A 68-year-old male presented to our hospital fever dyspnea that progressed hemoptysis systemic multiple organ failure, necessitating a tracheal intubation ventilator. diagnosis was made after Leptospira interrogans identified via metagenomic next-generation sequencing...
<title>Abstract</title> Background Anti-glomerular basement membrane (anti-GBM) disease is an autoimmune disorder that specifically affects the kidneys and lungs with presence of autoantibodies targeting GBM, causing rapid glomerulonephritis alveolar hemorrhage due to damage capillary bed. The anti-GBM secondary pulmonary <italic>Candida albicans</italic> infection has been rarely documented. Case presentation: A 58-year-old male suspected tuberculosis presented our hospital cough hemoptysis...
Whether hypervariable region 1 (HVR1)-targeting antibodies elicited during natural hepatitis C virus (HCV) infection contribute to clearance and what is the mechanism underlying remain unclear. Here, we demonstrated that treatment of HCV-infected hepatoma Huh7.5 cells with IgGs purified from 2 28 (7.1%) chronic (CHC) patients efficiently controlled infection, for which genotype 1b HVR1 (1bHVR1)-binding antibody was critical. Moreover, found 1bHVR1 peptide superior 2aHVR1 in rabbit...
To evaluate the efficacy and mechanistic bases of intravenous injection arsenic trioxide at clinical-relevant doses for treating an imiquimod-induced psoriasis-like mouse model.After inducing skin lesions on back mice with imiquimod, in each group were injected a clinical dose through tail vein. The changes gene expression, protein expression distribution relevant inflammatory factors evaluated inflicted area, mechanisms underlying As2O3 intervention. HaCaT cells used to establish vitro...
Objective To investigate the clinical characteristics of skin lesions tsutsugamushi disease.Methods The and 17 hospitalized patients with disease were analyzed. Results Of patients, 88.2% (15/17) developed eschar ulcer, 64.7% (11/17) had rashes. often solitary, painless nonpruritic 4 to 10 days after occurrence fever, indefinite locations average diameter 1.2 cm (range: 0.5 - 3.0 cm). was covered a black dry surface surrounded by ring-shaped erythematous halo, usually shedded 5 9 appearance...
Objective To investigate the apearance and characteristics of skin rashes in patients suffering from dengue fever.Methods Clinical data were retrospectively analyzed for 126 hospitalized with fever collected August to October,2007.Results Out fever,69.0% (87/126)had rashes,which usually developed day 1 11 after fever.About 59.7%(52/87)of these 3 7 fever.No eruption order was evidenced 59(67.8%)patients.Skin located both trunk limbs 38(43.7%)patients,and only 30 (34.5%)patients.The incidence...
Pelvic floor dysfunction has caused pain to the lives of majority female patients, and repeated visits hospital for treatment have also inconvenience patients. Therefore, a portable pelvic rehabilitation training system is designed help patients with personalized private treatment. The realizes independent mode selection through APP client, assists muscle electrical stimulation module, can realize recovery situation strength in real time AD acquisition module. experimental results show that...