A5079120771- Toxic Organic Pollutants Impact
- Aldose Reductase and Taurine
- Eicosanoids and Hypertension Pharmacology
- Pharmacogenetics and Drug Metabolism
- Carcinogens and Genotoxicity Assessment
- Arsenic contamination and mitigation
- Per- and polyfluoroalkyl substances research
- Effects and risks of endocrine disrupting chemicals
- Acute Lymphoblastic Leukemia research
- Retinoids in leukemia and cellular processes
- Renin-Angiotensin System Studies
- Birth, Development, and Health
- Inflammatory mediators and NSAID effects
- Hormonal Regulation and Hypertension
- Free Radicals and Antioxidants
- Cell death mechanisms and regulation
- Fatty Acid Research and Health
- Fluoride Effects and Removal
- Autophagy in Disease and Therapy
- Environmental Toxicology and Ecotoxicology
- Nitric Oxide and Endothelin Effects
- Cancer, Hypoxia, and Metabolism
- Pesticide Exposure and Toxicity
- Cancer, Lipids, and Metabolism
- Acute Myeloid Leukemia Research
Dalian Medical University
2013-2024
Bay Institute
2023
First Affiliated Hospital Zhejiang University
2023
Zhejiang University
2023
Second Affiliated Hospital of Dalian Medical University
2014-2023
Netaji Subhas National Institute of Sports
2021
Shanghai University of Sport
2021
University of Minnesota
2016-2020
Twin Cities Orthopedics
2018-2020
Lanzhou Veterinary Research Institute
2018
Blockade of angiotensin (Ang) II is efficient in various renal diseases. Although interest has focused on the hemodynamic changes and reduction proteinuria, recent studies emphasize nonhemodynamic effects Ang kidney injury. The aim this study was to clarify mechanisms immune system that alter balance helper T-cell (Th) subsets. We used a continuous, infusion model rats develop hypertension, tubulointerstitial damage, including de novo expression alpha-smooth muscle actin loss endothelial...
The polybrominated diphenyl ethers (PBDEs) are a group of flame retardants whose residues have markedly increased in the environment and human tissues during last decade. Of various congeners, BDE 47 (2,2′,4,4′-tetrabromodiphenyl ether) is typically predominant congener observed fish wildlife samples, as well tissues. Several studies indicate utero transfer PBDEs pregnancy with accumulating fetal tissues, thus potential for 47–mediated injury concern. In this study, we examined mechanisms to...
Purpose: The aim of this study was to explore the safety and efficacy radical prostatectomy with a novel Shurui single-port (SR-SP) robotic surgical system. Methods: A total 11 patients prostate cancer were enrolled in study. Extraperitoneal performed using SR-SP system for all patients. Clinicopathologic data, perioperative short-term outcomes prospectively collected analyzed. Results: Of patients, median age 65 years (range 52-73), body mass index 22.6 kg/m2 20.2-26.7). operative time 229...
The reno- and cardiovascular-protective effects of angiotensin II receptor blockers (ARBs), have been ascribed, at least in part, to their ability inhibit the formation advanced glycation end products (AGEs), independently effect on blood pressure. They act through decreased oxidative stress, unlike previously reported AGE inhibitors which entrap reactive carbonyl (RCOs) precursors AGEs. hypotensive ARBs', however, may limit use. In present study, we report synthesis a new inhibitor, TM2002,...
Household pesticide exposure during pregnancy has been associated with a more than 2-fold increased risk in infant leukemia, and chlorpyrifos (CPF) is among the most frequently applied insecticides. During early fetal development, liver hematopoietic organ majority of cells being CD34+ stem (CD34+HSC). The utero injury to CD34+HSC known underlie pathogenesis several blood disorders, often involving rearrangements mixed-lineage leukemia (MLL) gene on 11q23. In this study, we evaluated...
A new model of thrombotic microangiopathy (TMA) was previously developed, and it demonstrated that endothelial nitric oxide (NO) synthase (NOS) is upregulated in glomeruli this model. It hypothesized the synthesis NO, a potent vasodilator platelet inhibitory factor, induced as defense mechanism. The goal study to clarify role NO Ex vivo experiments using Western blotting functional assays upregulation NOS isolated from TMA rats. In experiments, five groups rats were studied, including with...
During fetal development, the liver serves as primary hematopoietic organ in which stem cells (HSC) comprise a large proportion of hepatic cell populations. Because HSC are capable initiating long-term hematopoiesis, injury to these during pregnancy may play role development disorders manifested after birth. Of interest is genetic etiology infant acute leukemias, characterized by chromosomal rearrangements 11q23 region involving mixed lineage leukemia ( MLL ) gene. These gene fusions also...
Objectives Angiotensin II plays a crucial role in the induction of oxidative stress and pathogenesis cardiovascular renal diseases, beneficial mechanisms angiotensin receptor 1 blockers (ARBs) are multifactorial. We investigated receptor-independent protective an ARB using primary-cultured mesangial cells from knockout or wild-type mice highly lipophilic ARB, telmisartan. Methods results Intracellular reactive oxygen species were estimated fluorogenic probe, CM-H2DCFDA. Non-angiotensin...
During fetal development, the liver serves as primary hematopoietic organ in which stem cells (HSC) capable of initiating long-term hematopoiesis comprise a large proportion hepatic cell population. Although HSC are potential targets for transplacental chemicals, little is known regarding their xenobiotic biotransformation ability. We quantitated steady-state mRNA expression six cytochrome P450 (P450) and 11 glutathione <i>S</i>-transferase (GST) isoforms CD34<sup>+</sup>-selected isolated...
Avenanthramides (AVA) are a group of diphenolic acids found only in oats that have anti-inflammatory and antioxidant effects. Absorption AVAs humans after oral consumption natural oat flour is unknown.To examine the appearance plasma ingestion cookies estimate key pharmacokinetic parameters.Male female nonobese participants (n = 16) consumed three made with containing high (229.6 mg/kg, H-AVA) or low (32.7 L-AVA) amounts AVAs, including AVA-A, AVA-B, AVA-C. Blood samples were collected at 0,...
The contamination of inactivated vaccine with non-structural proteins (NSPs) leads to a high false-positive rate, which is substantial barrier accurately differentiate foot-and-mouth disease virus (FMDV)-infected animals from vaccinated animals. To address this problem, new chemiluminescence immunoassay (CLIA) method was developed detect antibodies targeting the two recombinant epitope-based located in 3A and 3B. 3Aepitp-3Bepitp CLIA exhibited diagnostic sensitivity 94.0% specificity 97.5%...
Multiple myeloma (MM) is a uniformly fatal disease characterized by clonal proliferation of neoplastic plasma cells in the bone marrow and second most commol hematological malignancy.1 At present, cure for multiple has not been achieved with chemotherapeutic regimen, many patients die drug-resistant disease. Thus, development new effective anticancer agents to treat both early advanced MM seems be an attractive perspective. Chinese herbal medicines are treasures inherited from our ancestor,...