A5101596011- dental development and anomalies
- Antiplatelet Therapy and Cardiovascular Diseases
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Acupuncture Treatment Research Studies
- Platelet Disorders and Treatments
- Anesthesia and Pain Management
- Dental Trauma and Treatments
- MicroRNA in disease regulation
- Venous Thromboembolism Diagnosis and Management
- Genomics and Chromatin Dynamics
- Plant Virus Research Studies
- Extracellular vesicles in disease
- Hepatitis B Virus Studies
- Neurosurgical Procedures and Complications
- Cancer Research and Treatments
- Cervical Cancer and HPV Research
- Cell Adhesion Molecules Research
- Multiple Myeloma Research and Treatments
- Lipoproteins and Cardiovascular Health
- Acute Myocardial Infarction Research
- Autoimmune and Inflammatory Disorders Research
- Epigenetics and DNA Methylation
- Cardiac, Anesthesia and Surgical Outcomes
- Immune Cell Function and Interaction
Tangshan People's Hospital
2013-2024
Jiangxi Provincial Children's Hospital
2021-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Baotou Central Hospital
2023
Guangdong Medical College
2023
Liaocheng People's Hospital
2023
Weatherford College
2023
Credo Reference (United States)
2023
CCS Associates (United States)
2022
Guilin Medical University
2022
Deregulation of the c-Myc oncoprotein (Myc) is implicated in many types cancer. Myc a sequence-specific transcription factor that regulates genes involved control cell proliferation and apoptosis via mechanisms are still poorly understood. Cell transformation by involves its association with transformation-transactivation domain-associated protein (TRRAP) human histone acetyltransferase (HAT) GCN5. TRRAP GCN5 components variety shared distinct multiprotein HAT complexes diverse functions....
Abstract Innate immunity is important for host defense by eliciting rapid anti-viral responses and bridging adaptive immunity. Here, we show that endogenous lipids released from virus-infected cells activate lung γδ T to produce interleukin 17 A (IL-17A) early protection against H1N1 influenza infection. During infection, the cell pool constantly supplemented thymic output, with recent emigrants infiltrating into parenchyma airway acquire tissue-resident feature. Single-cell studies identify...
Background and Objective: Mammalian tooth root development is a long‐term process during which elongates along the apical direction accompanied with formation of periodontium. Considering heterogeneous region developing as functional entity, we observed characterized complex rat molar root. The aim present study was to investigate characteristics developmental capability in situ vitro . Material Methods: Histological analysis performed using hematoxylin eosin staining immunohistochemical...
Although the development of multi-disciplinary management has improved survival colorectal cancer (CRC), prognosis metastatic CRC patients remains poor. Accumulating evidence demonstrated that immunotherapy with vaccines and adoptive T cell transfusions may improve outcomes as an adjuvant to current standard treatment. In this phase I/II study, 71 who underwent radical surgery (stage I-III, n = 46) or palliative IV non-resectable synchronous metastases, 25) were included. first part sentinel...
Abstract Objective: The role of lncRNAs in tumor has been widely concerned. present study took HAS2-AS1 (the antisense RNA 1 HAS2) as a starting point to explore its expression glioma and the process migration invasion, providing strong theoretical basis for mining potential therapeutic targets glioma. Methods: Clinical data were obtained from Cancer Genome Atlas (TCGA) database differentially expressed analyzed by edgeR. hTFtarget was used predict upstream transcription factors JASPAR...
Summary Bone mineral density (BMD) is an important risk factor for osteoporosis and has strong genetic determination. While average BMD differs among major ethnic groups, several candidate genes have been shown to underlie variation within populations of the same ethnicity. To investigate whether may contribute differences in BMD, we studied degree differentiation between two groups: Caucasians Chinese. The variability these (1131 randomly selected individuals) was at six restriction sites...
Platelets play a pivotal role in atherothrombosis and the antiplatelet agents have been proved to be useful preventing onset of acute clinical events including myocardial infarction stroke. Increasing number natural compounds has identified potential agents. Here we report effect glaucocalyxin A (GLA), an ent-diterpenoid that isolated purified from aerial parts Rabdosia japonica (Burm. f.) var. glaucocalyx (Maxim.) Hara, investigate molecular mechanisms by which GLA inhibits platelet...
miR-139-5p is lowly expressed in various human cancers and exerts its antitumor effect through different molecular mechanisms, yet the mechanism of lung adenocarcinoma (LUAD) remains to be further elucidated. The study aimed at investigating role regulatory LUAD progression.Differential analysis was performed on miRNA expression data TCGA-LUAD dataset. qRT-PCR employed detect transcription levels MAD2L1 cells, while western blot carried out for detection protein expression. CCK-8 Transwell...
A pseudovirion-based neutralisation assay (PBNA) has been considered the gold standard for measuring specific antibody responses against human papillomavirus (HPV). However, this is labor intensive and therefore very difficult to implement in large-scale studies. Previous studies have evaluated agreement between virus-like particle (VLP)-based ELISA PBNA HPV vaccine-induced antibodies. concordance of these assays detect antibodies induced by natural infection not yet fully elucidated. In...
Background/Aim: Pancreatic cancer (PC) is currently the fourth leading cause of cancer-related mortality worldwide. Peripheral blood mononuclear cells (PBMCs) a subpopulation accessible and functional immune cells. Comparative analysis proteome PBMCs can help us elucidate mechanism disease find potential biomarkers for diagnosis. Materials Methods: were collected from healthy individuals, patients with benign diseases, pancreatic cancer. iTRAQ-2DLC-MS/MS SWATH methodologies applied to make...
Lupus nephritis is a rare immunological disorder. Genetic factors are considered important in its causation. We aim to systematically investigate the pathogenic gene variants patients with lupus nephritis.
The phosphatidylinositol 3–kinase (PI3K) signaling pathway is critical in modulating platelet functions. In the present study, we evaluated effect of S14161, a recently identified pan-class I PI3K inhibitor, on activation and thrombus formation. Results showed that S14161 inhibited human aggregation induced by collagen, thrombin, U46619, ADP dose-dependent manner. Flow cytometric studies convulxin- or thrombin-induced P-selectin expression fibrinogen binding single platelet. also spreading...
Mitofusin 2 (Mfn2) is expressed in numerous human tissues and serves a pivotal role cell proliferation. However, Mfn2 considered as an anti-tumor gene, silenced malignant tumors, including those of breast cancer. the mechanisms contributing to silencing mechanism its function cancer remain unclear. In present study, hypoexpression Mfn2, hypermethylation promoter, was confirmed cells by reverse transcription-quantitative polymerase chain reaction (PCR) methylation specific PCR, respectively....
Abstract Mesenchymal bone marrow stromal cells may be a source of to preseed decellularized biologic mesh materials for improved cellularization and promote more physiologic tissue after remodeling. Spontaneous differentiation mesenchymal on the material would undesirable. Conversely, induced stem (MSC) suggest that these have promise as scaffold bone, cartilage, or adipocyte formation. Two sources were evaluated in control wells. These MSCs also spontaneous porcine dermis mesothelium...
Background Acupuncture and non-steroidal anti-inflammatory drugs (NSAIDs) are used frequently to treat primary dysmenorrhoea. However, it is unclear whether this treatment greatly reduces the risk of Methods Eight databases were searched up January 2018. Pair-wise network meta-analyses conducted synthesize data from eligible studies. Results Seventeen randomized controlled trials included. The following acupuncture types showed more efficacy than NSAIDs in reducing dysmenorrhoea risk:...