A5041617397- Hepatitis C virus research
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer-related Molecular Pathways
- Prostate Cancer Treatment and Research
- Genetic Associations and Epidemiology
- Molecular Biology Techniques and Applications
- Bone health and osteoporosis research
- Epigenetics and DNA Methylation
- Prostate Cancer Diagnosis and Treatment
- RNA Research and Splicing
- Ferroptosis and cancer prognosis
- Growth Hormone and Insulin-like Growth Factors
- Cancer Genomics and Diagnostics
- Glaucoma and retinal disorders
- Immunotherapy and Immune Responses
- Cancer, Lipids, and Metabolism
- Bone Metabolism and Diseases
- Renal cell carcinoma treatment
- Wnt/β-catenin signaling in development and cancer
- Hepatitis Viruses Studies and Epidemiology
- Cytokine Signaling Pathways and Interactions
Southern Medical University
2017-2025
Nanfang Hospital
2017-2025
Affiliated Hospital of Youjiang Medical University for Nationalities
2022-2025
Hepatitis B Foundation
2022
NorthShore University HealthSystem
2015-2020
Fudan University
2010-2020
Huashan Hospital
2020
Shanghai Medical College of Fudan University
2020
Ruijin Hospital
2020
Zhongshan Hospital
2019
The Prolyl hydroxylase 1 (EGLN2) is known to affect tumorigenesis by regulating the degradation of hypoxia-inducible factor. Polymorphisms in EGLN2 may facilitate cancer cell survival under hypoxic conditions and directly associate with susceptibility. Here, we examined contribution a 4-bp insertion/deletion polymorphism (rs10680577) within distal promoter risk hepatocelluar carcinoma (HCC) Chinese populations. rs10680577 HCC was investigated 623 cases 1,242 controls replicated an...
Hepatitis B virus affects more than 2 billion people worldwide, 350 million of which have developed chronic hepatitis (CHB). The genetic factors that confer CHB risk are still largely unknown. We sought to identify variants for susceptibility in the Chinese population. undertook a genome‐wide association study (GWAS) 2,514 cases and 1,130 normal controls from eastern China. replicated 33 most promising signals eight previously reported loci through two‐stage validation totaling 6,600 8,127...
// Qianyi Xiao 1,* , Zhi-Jun Liu 2,3,* Sha Tao Yi-Min Sun 3 Deke Jiang 4 Hong-Lei Li 2 Haitao Chen 1 Xu Brittany Lapin 5 Chi-Hsiung Wang S. Lilly Zheng 4,5 Jianfeng 1,4,5,6,* and Zhi-Ying Wu 2,* Center for Genomic Translational Medicine Prevention, School of Public Health, Fudan University, Shanghai, China Department Neurology Research in Second Affiliated Hospital, the Collaborative Innovation Brain Science, Zhejiang University Medicine, Hangzhou, Institute Neurology, Huashan State Key...
Abstract Recent genome-wide associated studies (GWASs) have revealed several common loci with the risk of hepatitis B virus (HBV)- or C (HCV)-related hepatocellular carcinoma (HCC). We selected 15 single nucleotide polymorphisms (SNPs) identified through GWASs on HBV- HCV-related HCC and genotyped them in two independent Chinese cohorts chronic HBV carriers, including 712 LC cases 2601 controls. The association each SNP HBV-related was assessed by meta-analysis cohorts. Of 12 SNPs reported...
Activation of β-catenin, the central effector canonical wingless-type (Wnt) pathway, has been implicated in hepatocellular carcinoma (HCC). However, transcription regulation mechanism β-catenin gene HCC remains unknown. Here we report that human zinc finger protein 191 (ZNF191) is a potential regulator transcription. ZNF191, Krüppel-like protein, specifically interacts with TCAT motif, which constitutes HUMTH01 microsatellite tyrosine hydroxylase ( TH ) ex vivo . We demonstrate ZNF191...
Several different approaches are available to clinicians for determining prostate cancer (PCa) risk. The clinical validity of various PCa risk assessment methods utilizing single nucleotide polymorphisms (SNPs) has been established; however, these SNP-based have not compared. objective this study was compare the three most commonly used assessment. Participants were men (n = 1654) enrolled in a prospective development. Genotypes 59 risk-associated SNPs cohort. Three calculating genetic...
Background and Aims: Long-term maintenance of viral control, even HBsAg loss, remains a challenge for chronic hepatitis B (CHB) patients undergoing nucleos(t)ide analogue (NA) discontinuation. This study aimed to investigate the relationship between HBV-specific T cell responses targeting peptides spanning whole proteome clinical outcomes in CHB after NA Approach Results: Eighty-eight discontinuation were classified as responders (remained relapse-free up 96 wk) or relapsers (relapsed who...
Background & Aims: The human leukocyte antigen (HLA) locus is implicated in hepatocellular carcinoma (HCC) among chronic hepatitis B virus (HBV) carriers. We investigated associations of HLA variants, amino acid polymorphisms, zygosity, and evolutionary divergence (HED) with HBV-related HCC Han Chinese explored biological mechanisms. Approach Results: examined the variants (imputed 4-digit classical alleles polymorphisms), HED a discovery set (706 cases, 6,197 HBV carriers Taiwan)....
Summary Bone mineral density (BMD) is an important risk factor for osteoporosis and has strong genetic determination. While average BMD differs among major ethnic groups, several candidate genes have been shown to underlie variation within populations of the same ethnicity. To investigate whether may contribute differences in BMD, we studied degree differentiation between two groups: Caucasians Chinese. The variability these (1131 randomly selected individuals) was at six restriction sites...
Abstract Three genome-wide association studies (GWAS) have been conducted on the genetic susceptibility of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC), two which consistently identified tagging single nucleotide polymorphisms (SNPs) around HLA-DQ/DR . In contrast, large multi-centre between HBV genotype, mutations and risk HCC are relatively rare their interactions with host variants even less. We performed a study 1,507 HBV-related cases 1,560 persistent carriers as...
BACKGROUND Twenty-four prostate cancer (PCa) risk-associated single nucleotide polymorphisms (SNPs) in Chinese men have been cataloged. We evaluated whether these SNPs can independently predict outcomes of biopsy, and improve the predictive performance existing clinical variables. METHODS Three hundred eight consecutive patients that underwent biopsy for detection PCa at Huashan Hospital, Shanghai, China between April 2011 August 2012 were recruited. Clinical variables such as serum...
Interferon (IFN)‐α is a first‐line therapy for chronic hepatitis B (CHB) patients but only initiates response in minority of patients. A genetic variant, rs7574865 STAT4 , was recently reported to be associated with risk developing CHB and virus‐related hepatocellular carcinoma. We aimed determine whether this variant the IFNα treatment e antigen (HBeAg)‐positive studied 466 HBeAg‐positive who received either IFNα‐2b (n = 224) or pegylated IFNα‐2a 242) 48 weeks were followed an additional 24...
Hepatitis B virus (HBV) infection is a serious global health burden. TRIM26 has been reported to affect hepatitis C replication.To manifest the role of on HBV replication and explore if there are single-nucleotide polymorphisms (SNPs) in associated with response pegylated interferon-alpha (PegIFNα) treatment patients chronic (CHB).We investigated effect mechanism vitro. The association between SNPs PegIFNα was evaluated two independent cohorts including 238 707 HBeAg-positive CHB.Knockdown...
<h3>Objective</h3> Hepatoma-derived growth factor (HDGF)-related proteins (HRPs) comprise a family of six members and are characterised by conserved HATH domain. Among the members, HDGF was first to be identified as mitogenic shown play an important role in hepatocellular carcinoma pathogenesis. The aim present study is examine relevance HDGF-related protein-3 (HRP-3), another member HRP (HCC). <h3>Design</h3> HRP-3 expression HCC tissues measured quantitative reverse transcriptase PCR,...
Natural products have become sources of developing new drugs for the treatment cancer. To seek candidate compounds that inhibit growth liver cancer, components Chloranthus serratus were tested. Here, we report shizukaol D, a dimeric sesquiterpene from serratus, exerted inhibition effect on cancer cells in dose- and time-dependent manner. We demonstrated D induced to undergo apoptosis. More importantly, attenuated Wnt signalling reduced expression endogenous target genes, which resulted...