A5039786650- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Genetic Associations and Epidemiology
- Bladder and Urothelial Cancer Treatments
- Genetic factors in colorectal cancer
- Renal cell carcinoma treatment
- Epigenetics and DNA Methylation
- BRCA gene mutations in cancer
- Ferroptosis and cancer prognosis
- Molecular Biology Techniques and Applications
- Renal and related cancers
- Urinary and Genital Oncology Studies
- Urologic and reproductive health conditions
- DNA Repair Mechanisms
- Cancer Genomics and Diagnostics
- Cancer, Lipids, and Metabolism
- Liver Disease Diagnosis and Treatment
- Cancer Mechanisms and Therapy
- Cancer-related molecular mechanisms research
- Colorectal Cancer Screening and Detection
- Wnt/β-catenin signaling in development and cancer
- Urological Disorders and Treatments
- Sexual Differentiation and Disorders
- PI3K/AKT/mTOR signaling in cancer
- Cancer Risks and Factors
Huashan Hospital
2014-2023
Fudan University
2014-2023
Ruijin Hospital
2021
Shanghai Jiao Tong University
2021
NorthShore University HealthSystem
2018-2020
Background Germline mutations in CHEK2 have been associated with prostate cancer (PCa) risk. Our objective is to examine whether germline pathogenic can differentiate risk of lethal from indolent PCa. Methods A case‐case study 703 PCa patients and 1455 low‐risk localized European, African, Chinese origin was performed. DNA samples these were sequenced for . Mutation carrier rates their association analyzed using the Fisher exact test Kaplan‐Meier survival analysis. Results In entire...
BACKGROUND The use of serum [‐2]proPSA (p2PSA) and its derivative, the prostate health index (PHI), in detecting cancer (PCa) have been consistently shown to better performance than total prostate‐specific antigen (tPSA) discriminating biopsy outcomes western countries. However, little is known about their Chinese men. Our objective test p2PSA PHI added value tPSA METHODS Consecutive patients who underwent three tertiary hospitals Shanghai, China during 2012–2013 were recruited. Serum tPSA,...
The risk factors of bladder cancer recurrence after transurethral resection tumor (TURBt) were poorly understood, especially in Chinese population. This study evaluated the potential based on a population.A total 698 patients that received TURBt procedure our institute from 2000 to 2012 recruited this study. Clinical information was collected. followed up according schedule recommended by guideline.A 583 males (83.5%) and 115 females (16.5%) enrolled median follow-up duration 51.5 months....
Genistein is one of the main soy isoflavones in our daily diet. There were studies proving that high-dietary intake genistein may relate to low morbidity and mortality prostate cancer (PCa) Asian population. Since there few plasma level Chinese population, we performed this study preliminarily evaluate associations among genistein, epidemiologic factors PCa a Between 2012 2013, 100 men over age 40 underwent biopsy for at Huashan Hospital, Shanghai, China. Clinical information, information...
Genetic risk score (GRS) is an odds ratio (OR)-weighted and population-standardized method for measuring cumulative effect of multiple risk-associated single nucleotide polymorphisms (SNPs). We hypothesize that GRS a valid tool assessment most common cancers.Utilizing genotype phenotype data from The Cancer Genome Atlas (TCGA) Electronic Medical Records Genomics (eMERGE), we tested 11 cancer-specific GRSs (bladder, breast, colorectal, glioma, lung, melanoma, ovarian, pancreatic, prostate,...
Background The performance of prostate health index (phi) in predicting biopsy outcomes has been well established for patients with prostate-specific antigen (PSA) values between 2 and 10 ng/mL. However, the phi remains unknown PSA >10 ng/mL, vast majority Chinese patients. We aimed to assess ability predict cancer (PCa) high-grade disease (Gleason Score ≥7) on a population. Methods This is prospective, observational, multi-center study consecutive who underwent transrectal ultrasound guided...
The performances of the Prostate Cancer Prevention Trial (PCPT) risk calculator and other calculators for prostate cancer (PCa) prediction in Chinese populations were poorly understood. We performed this study to build (Huashan calculators) based on population validated performance prostate-specific antigen (PSA), PCPT calculator, Huashan a validation cohort. built data from 1059 men who underwent initial biopsy January 2006 December 2010 training Then, we PSA, an observational 2011 2014....
Abstract Background While higher genetic risk score (GRS) has been statistically associated with increased disease (broad‐sense validity), the concept and tools for assessing validity of reported GRS values from tests (narrow‐sense validity) are underdeveloped. Methods We propose two benchmarks narrow‐sense GRS. The baseline benchmark requires that mean value in a general population approximates 1.0. calibration assesses agreement between observed risks estimated (GRS values). assessed...
This study was performed to evaluate prostate-specific antigen-age volume (PSA-AV) scores in predicting prostate cancer (PCa) a Chinese biopsy population. A total of 2355 men who underwent initial from January 2006 November 2015 Huashan Hospital were recruited the current study. The PSA-AV calculated and assessed together with PSA density (PSAD) retrospectively. Among 2133 patients included analysis, 947 (44.4%) diagnosed PCa. mean age, PSA, positive rates digital rectal examination result...
In the postscreening era, physicians are in need of methods to discriminate aggressive from nonaggressive prostate cancer (PCa) reduce overdiagnosis and overtreatment. However, studies have shown that prognoses (e.g., progression mortality) differ even among individuals with similar clinical pathological characteristics. Existing risk classifiers (TMN grading system, Gleason score, etc.) not accurately enough represent biological features PCa. Using new genomic technologies, novel biomarkers...
Here we conducted an evidence-based study in developing and validating a urinary biomarker combination of gene methylation assays patients with hematuria.A number 99 urine samples were obtained detected from Chinese hematuria.The Cancer Genome Atlas cohort (HM450) beta-values clinical data 412 bladder cancer 21 matching normal tissue was included as validation series.A risk score formula then developed calculated by the targeted genes, weighted their estimated regression coefficients...
Abstract MicroRNAs (miRNAs) are involved in the regulation of gene expression via incomplete base pairing to sequence motifs at three prime untranslated regions (3′‐UTRs) mRNAs and play critical roles etiology cancers. Single nucleotide polymorphisms (SNPs) 3′‐UTR miRNA‐binding may influence miRNA affinity. However, this biological mechanism prostate cancer (PCa) remains unclear. Here, a three‐stage genome‐wide association study SNPs ( n =33 117) is performed 5515 Chinese men. Three...
Objectives To perform a systematic evaluation of whether germline DNA repair gene mutations in bladder cancer ( BC a) are associated with increased risk and aggressive disease. Materials Methods Germline from 98 patients was analysed for 54 genes using customized targeted sequencing panel. Population control data were obtained the public databases Exome Aggregation Consortium database Genome Database. Mutation pathogenicity annotated based on American College Medical Genetics criteria,...
Genetic risk score (GRS) based on disease risk-associated single nucleotide polymorphisms (SNPs) is an informative tool that can be used to provide inherited information for specific diseases in addition family history. However, it still unknown whether only SNPs are implicated a racial group should when calculating GRSs. The objective of this study compare the performance race-specific GRS and nonrace-specific predicting prostate cancer (PCa) among 1338 patients underwent biopsy Shanghai,...
Introduction:The associations between Prostate cancer (PCa) and germline copy number variations (CNVs) in genome-wide level based on Chinese population are unknown.The objective of this study was to identify possible PCa-risk associated CNV regions population.Materials Methods: We performed a association for 1,417 PCa cases 1,008 controls population.Results: 7 risk-associated CNVs were identified after analyses (P <7.2×10 -6 ).Another 34 found be potentially (P<0.05).Among the total 41 CNVs,...
Background Few genes have germline mutations which predispose men to more aggressive prostate cancer (PCa). This study evaluated the contribution of loss function (LOF) variants in PPFIBP2 risk lethal PCa. Methods A case‐case 1414 PCa patients with and low‐risk localized was performed. Germline DNA samples from these were sequenced for . Mutation carrier rates association analyzed using Fisher exact test, logistic regression, Kaplan‐Meier survival analysis. Results In entire population,...
CX3CL1 is a chemokine that may play important roles in cancer immune regulation. Its mechanism bladder (BCa) poorly understood. The objective of the current study was to evaluate association between and BCa related biological mechanisms. A total 277 patients with were enrolled present study. expression disease outcome evaluated. In vitro vivo experiments performed using TCCSUP cell line investigate function BCa. Compared low expression, high significantly associated poorer progression-free...
XL388 is a mammalian target of rapamycin (mTOR) kinase inhibitor. We demonstrated that inhibited survival and proliferation renal cell carcinoma (RCC) lines (786-0 A549) primary human RCC cells. activated caspase-dependent apoptosis in the blocked mTOR complex 1 (mTORC1) mTORC2 activation, depleted hypoxia-inducible factor 1α (HIF1α) HIF-2α expression Yet, was ineffective cells with shRNA knockdown or kinase-dead mutation. Notably, more efficient than mTORC1 inhibitors (rapamycin, everolimus...
// Yishuo Wu 1, 2, * , Ning Zhang Kaiwen Li 3, Haitao Chen 4, 5 Xiaolin Lin Yang Yu 2 Yuancheng Gou Jiangang Hou Deke Jiang 4 Rong Na 6, 7 Xiang Wang Qiang Ding Jianfeng Xu 1 Department of Urology, Huashan Hospital, Fudan University, Shanghai, PR China Institute 3 Sun Yat-sen Memorial Yet-sen Guangdong, State Key Laboratory Genetic Engineering, School Life Sciences, Center for Epidemiology, 6 Health Communication Institute, Public Health, Program Personalized Cancer Care, NorthShore...
To investigate the difference between preoperative radiologic tumor size (RTS) and postoperative pathologic (PTS) in patients who underwent nephrectomy for renal cell carcinoma. We retrospectively reviewed 257 received computed tomography (CT) before radical or partial carcinoma from January 2010 to May 2015 Huashan Hospital, Shanghai. RTS was defined as largest diameter of measured by CT PTS surgical specimens. Among all subjects, mean larger than (4.57 ± 2.15 vs. 4.02 cm, P = 0.004) with a...
// Ning Zhang 1,2,* , Yishuo Wu Jian Gong 2* Kaiwen Li 3 Xiaolin Lin 2,4,5 Haitao Chen 5 Yang Yu 1,2 Yuancheng Gou Jiangang Hou Deke Jiang 4 Rong Na 1,2,6,7 Xiang Wang Qiang Ding and Jianfeng Xu 2,3,4,7 1 Department of Urology, Huashan Hospital, Fudan University, Shanghai, PR China 2 Institute Sun Yat-sen Memorial Yet-sen Guandong, State Key Laboratory Genetic Engineering, School Life Sciences, Center for Epidemiology, 6 Health Communication Institute, Public Health, 7 Program Personalized...