A5003966752- Liver Disease Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Prostate Cancer Diagnosis and Treatment
- BRCA gene mutations in cancer
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Global Cancer Incidence and Screening
- Rheumatoid Arthritis Research and Therapies
- Genetic Associations and Epidemiology
- Opioid Use Disorder Treatment
- Nutrition, Genetics, and Disease
- Circular RNAs in diseases
- Bladder and Urothelial Cancer Treatments
- MicroRNA in disease regulation
- Health Systems, Economic Evaluations, Quality of Life
- Urinary Bladder and Prostate Research
- Cell death mechanisms and regulation
- Biosimilars and Bioanalytical Methods
- Urinary and Genital Oncology Studies
- Urological Disorders and Treatments
- Colorectal Cancer Screening and Detection
- Plant and Fungal Interactions Research
- Liver physiology and pathology
University of Colorado Anschutz Medical Campus
2022-2023
University of Colorado Denver
2022-2023
University of Illinois Chicago
2019-2021
Illinois College
2019-2021
NorthShore University HealthSystem
2015-2020
University of Chicago
2016-2020
Huashan Hospital
2020
Fudan University
2020
657 Oslo
2016
Prostate Cancer Research
2016
Chronic pain is difficult to treat in individuals with substance use disorders and, when not resolved, can have a negative impact on disorder treatment outcomes. This study tested the efficacy of psychosocial management intervention, ImPAT (improving during addiction treatment), that combines content related managing without use.Single-site, parallel-groups randomized controlled trial comparing supportive psychoeducational control (SPC) condition; follow-up assessments occurred at 3, 6 and...
Interferon (IFN)‐α is a first‐line therapy for chronic hepatitis B (CHB) patients but only initiates response in minority of patients. A genetic variant, rs7574865 STAT4 , was recently reported to be associated with risk developing CHB and virus‐related hepatocellular carcinoma. We aimed determine whether this variant the IFNα treatment e antigen (HBeAg)‐positive studied 466 HBeAg‐positive who received either IFNα‐2b (n = 224) or pegylated IFNα‐2a 242) 48 weeks were followed an additional 24...
Background Benign prostatic hyperplasia (BPH) and associated lower urinary tract symptoms (LUTS) are common conditions. Little is known about their etiologies except that studies have suggested a substantial heritable component. Our objective to provide comprehensive, genome-wide evaluation of inherited risks possible mechanisms etiology in BPH. Methods We performed three-stage, association study (GWAS) men from three independent populations, the REduction by DUtasteride prostate Cancer...
Background The performance of prostate health index (phi) in predicting biopsy outcomes has been well established for patients with prostate-specific antigen (PSA) values between 2 and 10 ng/mL. However, the phi remains unknown PSA >10 ng/mL, vast majority Chinese patients. We aimed to assess ability predict cancer (PCa) high-grade disease (Gleason Score ≥7) on a population. Methods This is prospective, observational, multi-center study consecutive who underwent transrectal ultrasound guided...
Objectives To perform a systematic evaluation of whether germline DNA repair gene mutations in bladder cancer ( BC a) are associated with increased risk and aggressive disease. Materials Methods Germline from 98 patients was analysed for 54 genes using customized targeted sequencing panel. Population control data were obtained the public databases Exome Aggregation Consortium database Genome Database. Mutation pathogenicity annotated based on American College Medical Genetics criteria,...
Summary Background To date, 14 single‐nucleotide polymorphisms (SNPs) have been identified as susceptibility loci for chronic hepatitis B (CHB). Aim investigate if these SNPs are associated with treatment response of e antigen (HBeAg)‐positive CHB patients. Methods We performed a retrospective analysis 1623 Han Chinese HBeAg‐positive patients (782 treated pegylated interferon alpha [PegIFNα] 48 weeks plus 24 follow‐up, and 841 nucleos(t)ide analogues [NUCs] 104 weeks) included in four...
Genetic risk score (GRS) based on disease risk-associated single nucleotide polymorphisms (SNPs) is an informative tool that can be used to provide inherited information for specific diseases in addition family history. However, it still unknown whether only SNPs are implicated a racial group should when calculating GRSs. The objective of this study compare the performance race-specific GRS and nonrace-specific predicting prostate cancer (PCa) among 1338 patients underwent biopsy Shanghai,...
Single-nucleotide polymorphisms (SNPs) of microRNAs (miRNAs) are considered potential markers cancer risk and prognosis in various cancers. In the current study, primary aim is to determine whether miR-492G>C polymorphism (rs2289030) altered hepatocellular carcinoma (HCC) prognosis. The SNP rs2289030 miR-492 was genotyped using DNA from blood samples 362 HCC patients that had undergone surgical resection a tumor. associations between overall survival demographic characteristics, clinical...
Background Although the clinical validity of risk-associated single nucleotide polymorphisms (SNPs) for assessment disease susceptibility has been consistently established, risk reclassification from increasing numbers implicated SNPs raises concern that it is premature use. Our objective to assess degree and impact with number SNPs. Methods A total 3239 patients Reduction by Dutasteride Prostate Cancer Events (REDUCE) trial were included. Four genetic scores (GRSs) calculated based on sets...
Single nucleotide polymorphisms (SNPs) within microRNAs (miRNAs) are considered potential markers for risk and prognosis of various cancers. In the current study, we aimed to determine whether miR-608 rs4919510 affected hepatocellular carcinoma (HCC) prognosis. We genotyped using DNA from blood samples 362 HCC patients receiving surgical resection tumor. Associations between overall survival (OS) demographic characteristics clinical features were estimated Cox proportional hazards model....
The aim of our study was to determine the impact genetic polymorphisms in caspase (CASP) genes on prognosis hepatocellular carcinoma (HCC). We genotyped 7 potentially functional CASP3, CASP7, CASP8, CASP9, CASP10 362 HCC patients receiving surgical resection tumor. associations genotype and haplotype with overall survival (OS) disease free (DFS) were analyzed by using Cox proportional hazards model. found that CASP9 rs4645981 C allele significantly associated positive effect DFS (P = 0.011...
Abstract Background Recent genome-wide association studies (GWASs) have suggested several susceptibility loci of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) by statistical analysis at individual single-nucleotide polymorphisms (SNPs). However, these only explain a small fraction HBV-related HCC heritability. In the present study, we aimed to identify additional using advanced knowledge-based analysis. Methods We performed (including gene- and gene-set-based tests) on...
Abstract Background Genome-wide association studies have identified thousands of disease-associated single nucleotide polymorphisms (SNPs). A subset these SNPs may be additively combined to generate genetic risk scores (GRSs) that confer for a specific disease. Although the clinical validity GRSs predict diseases has been well established, there is still great need determine their utility by applying in primary care cancer assessment and targeted intervention. Methods This study involved 281...
Purpose Family history assigns equivalent risk to all relatives based upon the degree of relationship. Recent genetic studies have identified single nucleotide polymorphisms (SNPs) that can be used calculate a score (GRS) determine prostate cancer (PCa) risk. We sought whether GRS stratify PCa among individuals in families considered at higher due their family PCa. Materials and Methods members with hereditary were recruited genotyped for 17 SNPs associated A was calculated subjects....
Page 1325) show that hepatic stellate cells integrate signals from Kupffer and sinusoidal endothelial to mediate inflammatory damage hepatocytes.Activation of DP1 prostaglandin receptors on the with BW245C inhibits this process.Using example concanavalin A (ConA)induced hepatitis, they agent mitigates hepatocyte injury.
Abstract Background: Genome-wide association studies have identified thousands of disease-associated single nucleotide polymorphisms (SNPs). A subset these SNPs may be additively combined to generate genetic risk scores (GRSs) that confer for a specific disease. Although the clinical validity GRSs predict diseases has been well established, there is still great need determine their utility by applying in primary care cancer assessment and targeted intervention. Methods: This study involved...
You have accessJournal of UrologyProstate Cancer: Markers II1 Apr 2016MP07-08 THE PLATEAU EFFECT OF NUMBER PROSTATE CANCER RISK-ASSOCIATED SINGLE NUCLEOTIDE POLYMORPHISMS USED TO ASSESS GENETIC RISK Haitao Chen, Vignesh T. Packiam, Brian Helfand, Carly A. Conran, S. Lilly Zheng, William B. Isaacs, Charles Brendler, and Jianfeng Xu ChenHaitao Chen More articles by this author , PackiamVignesh Packiam HelfandBrian Helfand ConranCarly Conran ZhengS. Zheng IsaacsWilliam Isaacs BrendlerCharles...