Context: Understanding the menopause association with body weight is important because excess increases risk for stroke, incident cardiovascular disease, mortality, and all-cause mortality among middle-aged. Objective: The objective of this study was to examine chronological age ovarian consider how these could influence size composition in midlife women. Design Setting: Study Women’s Health Across Nation a longitudinal, community-based study. This report uses data from Michigan site....

The objective of the study was to determine whether anti-Mullerian hormone (AMH) and inhibin B are viable endocrine biomarkers for framing menopause transition from initiation final menstrual period (FMP).We assayed AMH, B, FSH in 300 archival follicular phase specimens 50 women with six consecutive annual visits commencing 1993 when all were pre- perimenopausal stages. Subsequently each woman had a documented FMP. assay results fitted as individual-woman profiles then related time FMP age...

Low bone mineral density (BMD) is a major risk factor for development of osteoporosis; increasing evidence suggests that attainment and maintenance peak mass as well turnover loss have strong genetic determinants. We examined the association BMD levels their change over 3-year period, polymorphisms estrogen receptor (ER), vitamin D (VDR), type I collagen, osteonectin, osteopontin, osteocalcin genes in pre- perimenopausal women who were part Michigan Bone Health Study, population-based...

OBJECTIVE AND CONTEXT: Our objective was to examine predictability of reproductive hormone concentrations for bone mineral density (BMD) loss during the menopausal transition.We conducted a longitudinal (five annual examinations), multiple-site (n = 5) cohort study, Study Women's Health Across Nation (SWAN).Participants included, at baseline, 2311 premenopausal or early perimenopausal African-American, Caucasian, Chinese, and Japanese women.We assessed dual-energy x-ray absorptiometry lumbar...

Abstract Radial bone mineral density (BMD) of 217 white women aged 22–54 years from a single rural community was evaluated in 1984 using single-photon absorptiometry. BMD measured at site one-third the distance wrist to elbow, that represents predominantly cortical tissue. Most these (181; 83%) were reexamined 5 later. The overall average year radial loss -5.6%. rate -4.5% for retaining positive estrogen status follow-up (n = 108) and -7.4% who negative 73). Baseline measures highly...

<h3>Importance</h3> Opioid-prescribing policies and guidelines aimed at reducing inappropriate opioid prescribing may lead physicians to stop opioids. Patients thus encounter difficulties finding primary care practitioners willing for them if they take <h3>Objectives</h3> To assess practitioner willingness accept continue opioids new patients with pain whether this differs across payer types. <h3>Design, Setting, Participants</h3> This survey study used a simulated patient call audit method....

Objective To determine whether Caucasian women ages 28–48 years with newly defined osteoarthritis (OA) would have greater bone mineral density (BMD) and less turnover over time than without OA. Methods Data were derived from the longitudinal Michigan Bone Health Study. Period prevalence 3-year incidence of OA based on radiographs dominant hand both knees, scored Kellgren/Lawrence (K/L) scale. scores related to BMD, which was measured by dual-energy x-ray absorptiometry, serum osteocalcin...

Abstract While there is substantial evidence of the importance endogenous and exogenous estrogen in reproductive health chronic disease, little consideration androgens women's health. In Michigan Bone Health Study (1992–1995), authors examined correlates testosterone concentrations pre- perimenopausal women (i.e., age, menopausal status, body composition, lifestyle behaviors) a population-based longitudinal study including three annual examinations among 611 aged 25–50 years identified...

To prospectively compare magnetic resonance (MR) imaging-defined abnormalities of osteoarthritis (OA) the knee with radiographic severity measurements OA and self-reported pain.This study was approved by institutional review board University Michigan. Informed consent obtained for this HIPAA-compliant study. Knee MR imaging performed in 117 women (mean age, 46 years; range, 32-56 years) from a community-based arthritis (n = 1053) 30 each four categories: (a) no pain knee, (b) (c) (d) knee....

Abstract Objective To determine if levels of endogenous estrogen or metabolites are associated with an increased risk developing knee osteoarthritis (OA) in women. Methods Serum estradiol (E 2 ) and urinary (2‐hydroxyestrone 16α‐hydroxyestrone) radiographically defined prevalent incident OA 842 white African American women from the Southeast Michigan Arthritis Cohort. Results The mean age body mass index (BMI) cohort were 42.3 years 28.5 kg/m , respectively. Women who developed had...

We measured two bone-formation markers, osteocalcin and bone-specific alkaline phosphatase, one bone-resorption marker, N-telopeptide, in a longitudinal study order to describe levels of these markers lactating nonlactating women after parturition. This 18-month postpartum period included an initial 6 months which 5% short-term bone loss occurred at both spine femoral neck among breast-feeding women. The second part the was characterized by recovery who had lost bone. These bone-change...

Abstract Background and Objective: The objective of the study was to describe bone loss rates across transmenopause related FSH staging final menstrual period (FMP). Design Setting: This a population-based cohort 629 women (baseline age 24–44 yr) with annual data points over 15 yr. Measurements: Measures were mineral density (BMD), define four stages, bleeding cessation FMP. Bone reported by obesity status. Results: Annualized lumbar spine began in stage 3, which occurs approximately 2 yr...

There is a need to better understand potential bone mineral density (BMD) loss during the menopausal transition since this period may include initiation of interventions. The study purpose was determine if there BMD at femoral neck, lumbar spine, or total body sites in population-based women approaching transitioning midlife. 583 enrollees were 25-45 years age first four annual measurements from 1992 through 1996. Bone content and width measured using dual-energy X-ray absorptiometry....

Abstract We evaluated five genetic markers for products that contribute to skeletal mineralization including the Sp1 polymorphism type I collagen Ai (COLIA1), vitamin D receptor (VDR) translation initiation site polymorphism, promoter of osteocalcin gene containing a C/T estrogen (ER) TA repeat, and polymorphic (AGC)n in androgen receptor. These were their potential relationship with bone mineral density (BMD), measured by dual-energy X-ray densitometry, or its 3-year change. Additionally,...

To delineate the role of hormone levels, menopause status, exogenous use, and personal characteristics in changing prevalence impact symptoms.Annual longitudinal data were from Michigan Bone Health Study enrollees aged 24 to 44 years at baseline followed up for a 10-year period beginning 1992. In self-administered interviews, women reported presence degree bother (values 1 = low 8 high) symptoms related sexuality, vasomotor, sleep/fatigue, negative mood, hair/skin, urinary problems....

To determine if pregnancy after an extended period of lactation curtails the recovery maternal bone mineral density.Twenty-five women who fully breast-fed their infants for at least 6 months and had a subsequent within 18 initiating were studied longitudinally. Twenty controls similarly, but no pregnancy. The healthy, well-nourished, between 20-40 years old. Bone density was measured by dual x-ray energy absorptiometry spine hip.Both cases lost with lactation. case group comparable to...

To determine if smoking, obesity, and insulin resistance mediated age at final menstrual period (FMP), we examined anti‐Müllerian hormone (AMH), inhibin B, follicle‐stimulating (FSH) as biomarkers of changing follicle status ovarian aging. We performed a longitudinal data analysis from cohort premenopausal women followed to their FMP. Our results found that smokers had an earlier FMP ( P &lt; 0.003) more rapid decline in AMH slope relative 0.002). Smokers lower baseline B level the than...

Chronic pain is difficult to treat in individuals with substance use disorders and, when not resolved, can have a negative impact on disorder treatment outcomes. This study tested the efficacy of psychosocial management intervention, ImPAT (improving during addiction treatment), that combines content related managing without use.Single-site, parallel-groups randomized controlled trial comparing supportive psychoeducational control (SPC) condition; follow-up assessments occurred at 3, 6 and...