A5075536897- Lung Cancer Diagnosis and Treatment
- Bladder and Urothelial Cancer Treatments
- Esophageal Cancer Research and Treatment
- Prostate Cancer Treatment and Research
- Advanced Radiotherapy Techniques
- Inflammatory mediators and NSAID effects
- Lung Cancer Treatments and Mutations
- Pain Mechanisms and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Urinary and Genital Oncology Studies
- Osteoarthritis Treatment and Mechanisms
- Shoulder Injury and Treatment
- Lung Cancer Research Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Head and Neck Surgical Oncology
- Radiomics and Machine Learning in Medical Imaging
- Cancer Immunotherapy and Biomarkers
- Epigenetics and DNA Methylation
- Helicobacter pylori-related gastroenterology studies
- Cancer-related molecular mechanisms research
- Brain Metastases and Treatment
- Gastric Cancer Management and Outcomes
- Muscle Physiology and Disorders
- Genetic factors in colorectal cancer
- Head and Neck Cancer Studies
Ruijin Hospital
2019-2025
Shanghai Jiao Tong University
2019-2025
Janssen (United States)
2024
Nanjing Drum Tower Hospital
2024
Fudan University
2006-2019
Huashan Hospital
1998-2019
Xian Yang Central Hospital
2019
Sanofi (United States)
2015-2019
Shenzhen Second People's Hospital
2018
Allergan (United States)
2006-2015
Neutral nanomaterials functionalized with PEG or similar molecules have been popularly employed as nanomedicines. Compared to positive counterparts that are capable of harnessing the well-known proton sponge effect facilitate their escape from lysosomes, it is yet unclear how neutral substances got entry into cytosol. In this study, by taking PEGylated, Au nanospheres an example, we systematically investigated time-dependent translocation postuptake. Specifically, harnessed dissipative...
Objectives: OnabotulinumtoxinA (onabotA) attenuates peripheral nociceptive transduction and consequently neuronal firing. The aim of this mechanistic study was to evaluate the effect intra-articular (IA) onabotA in patients with painful knee osteoarthritis (OA).Method: We conducted a double-blind, randomized, placebo-controlled, 12-week trial using single ultrasound-guided IA injection (200 U). Patients (N = 121) were randomized receive (n 61) or placebo 60). Mechanistic pain biomarkers...
Prostate cancer (PCa) is one of the most lethal causes cancer-related death in male. It characterized by chromosomal instability and disturbed signaling transduction. E3 ubiquitin ligases are well-recognized as mediators leading to genomic alterations malignant phenotypes. There a lack systematic study on novel oncodrivers with clinical significance PCa. In this we used clustered regularly interspaced short palindromic repeats (CRISPR) system screen 656 or tumor repressors PCa cells. We...
The protein corona effect refers to the phenomenon wherein nanomaterials in bloodstream are coated by serum proteins, yet how coronated interact with blood vessels and its toxicity implications remain poorly understood. In this study, we investigated corona-related vessel using an all-humanized assay integrating organoids patient-derived serum. Initially, screened various discern parameters including size, morphology, hydrophobicity, surface charge, chirality-dependent difference influence...
The distal short arm of human chromosome 1 (1p36) is commonly altered in primary hepatoma tumors and cell lines. This region includes the RIZ gene, a member PR (PRDI-BF1/BLIMP1 homology) domain family transcription factors. An unusual feature this yin-yang involvement cancers. Two products are normally produced from which differ by presence or absence domain; PR-plus product disrupted underexpressed whereas PR-minus present overexpressed cancer cells. RIZ1 candidate tumor suppressor because...
Inflammatory bowel disease (IBD) is often triggered and/or exacerbated by nonsteroidal anti-inflammatory drugs (NSAIDs). Among various prostanoids affected NSAIDs, prostaglandin E<sub>2</sub> (PGE<sub>2</sub>), in particular, seems to play critical roles IBD via the EP4 receptor, one of four PGE<sub>2</sub> receptor subtypes (EP1–4). An agonist,...
Bone cells are subject to interstitial fluid flow (IFF) driven by venous pressure and mechanical loading. Rapid dynamic changes in loading cause transient gradients IFF. The effects of pulsatile (temporal shear) on rat UMR106 primary osteoblastic were studied. Pulsatile induced a 95% increase S-phase compared with static controls. In contrast, ramped steady stimulated only 3% increase. Similar patterns induction also observed cells. significantly increased relative cell number 37 62% at 1.5...
This trial evaluated the efficacy and safety of GZ389988A, a tropomyosin receptor kinase A (TrkA) inhibitor, in subjects with painful knee osteoarthritis (OA).In this single center, double-blind, placebo-controlled randomized trial, 104 moderate-to-severe OA pain were enrolled to receive intra-articular (IA) injection either GZ389988A or placebo. Efficacy measures assessed over 12 weeks included walking (Western Ontario McMaster Universities Osteoarthritis Index [WOMAC] A1), overall pain,...
AIM:To investigate EP4-selective agonist effect on indomethacin-induced gastric lesions and the spontaneous healing of chronic ulcers. METHODS:In a mouse model bleeding with high dose indomethacin (20 mg/kg), an was administered orally.Stomach mucous regeneration were monitored.In ulcer induced by acetic acid, EP4 evaluated in presence or absence low (3 mg/kg).In cultured human cells, indomethacininduced apoptosis assessed flow cytometry. RESULTS:The reduced acute hemorrhagic damage promoted...