Prostate cancer (PCa) is one of the most lethal causes cancer-related death in male. It characterized by chromosomal instability and disturbed signaling transduction. E3 ubiquitin ligases are well-recognized as mediators leading to genomic alterations malignant phenotypes. There a lack systematic study on novel oncodrivers with clinical significance PCa. In this we used clustered regularly interspaced short palindromic repeats (CRISPR) system screen 656 or tumor repressors PCa cells. We...

Abstract Aberrant epigenetic reprogramming represents a hallmark of renal cell carcinoma (RCC) tumorigenesis and progression. Whether there existed other vulnerabilities that could serve as therapeutic targets remained unclear promising. Here, we combined the clustered regularly interspaced short palindromic repeats functional screening results multiple RCC datasets to identify JMJD6 potent target in RCC. expression correlated with poor survival outcomes patients promoted progression vitro...

Background The status of prostate-specific antigen (PSA) screening is unclear in China. Evidence regarding the optimal frequency and interval serial for prostate cancer (PCa) disputable. Objective This study aimed to depict PSA explore PCa Methods A 13-year prospective cohort was conducted using Chinese Electronic Health Records Research Yinzhou study’s data set. total 420,941 male participants aged ≥45 years were included between January 2009 June 2022. Diagnosis PCa, cancer-specific death,...

To accurately describe dynamic vegetation changes, high temporal and spectral resolution data are urgently required. Optical images contain rich information but limited by poor weather conditions cloud contamination. Conversely, synthetic-aperture radar (SAR) is effective under all contains insufficient to recognize certain changes. Conditional adversarial networks (cGANs) can be adopted transform SAR (Sentinel-1) into optical (Landsat8), which exploits the advantages of both images. As...

Genome-wide association studies have identified 270 loci conferring risk for prostate cancer (PCa), yet the underlying biology and clinical impact remain to be investigated. Here we observe an enrichment of transcription factor genes including HNF1B within PCa risk-associated regions. While focused on 17q12/HNF1B locus, find a strong eQTL multiple potential causal variants involved in regulation expression PCa. An unbiased genome-wide co-expression analysis reveals PCa-specific somatic...

The risk of second primary cancers (SPC) is increasing after the first (FPC) are diagnosed and treated. underlying causal relationship remains unclear. We conducted a pan-cancer association (26 cancers) study in Surveillance, Epidemiology, End Results (SEER) database (non-Hispanic whites). standardized incidence ratio (SIR) was estimated as SPCs cancer survivors based on general population. Furthermore, effect evaluated by two-sample Mendelian Randomization (MR, 13 FPCs) UK Biobank (UKB,...

Abstract MicroRNAs (miRNAs) are involved in the regulation of gene expression via incomplete base pairing to sequence motifs at three prime untranslated regions (3′‐UTRs) mRNAs and play critical roles etiology cancers. Single nucleotide polymorphisms (SNPs) 3′‐UTR miRNA‐binding may influence miRNA affinity. However, this biological mechanism prostate cancer (PCa) remains unclear. Here, a three‐stage genome‐wide association study SNPs ( n =33 117) is performed 5515 Chinese men. Three...

Abstract Background Legislation of cannabis use has been approved in many European and North American countries. Its impact on urological cancers is unclear. This study was conducted to explore the association between risk cancers. Methods We identified 151,945 individuals with information UK Biobank from 2006 2010. Crude age‐standardized incidence ratios different were evaluated entire cohort subgroups. Cox regression performed for survival analysis. Results Previous a significant...

Anticipating the postoperative pathological stage and potential for adverse features of prostate cancer (PCa) patients before radical prostatectomy (RP) is crucial guiding perioperative treatment.

Currently, prostate cancer (PCa) prebiopsy medical image diagnosis mainly relies on mpMRI and PI-RADS scores. However, has its limitations, such as inter- intra-radiologist variability the potential for imperceptible features. The primary objective of this study is to evaluate effectiveness a machine learning model based radiomics analysis MRI T2-weighted (T2w) images predicting PCa in cases.

Polygenic risk score (PRS) has shown promise in predicting prostate cancer (PCa) risk. However, the application of PRS non-European ancestry was poorly studied.We constructed using 68, 86, or 128 PCa-associated single-nucleotide polymorphisms (SNPs) identified through a large-scale Genome-wide association study (GWAS) European population. A calibration approach performed to adjust exact value for each ancestry. The conducted East Asian (ChinaPCa Consortium, n = 2379), (UK Biobank, 209,172),...

This study aimed to evaluate the clinical utility of 18F-PSMA-1007 positron emission tomography (PSMA PET)/magnetic resonance imaging (MRI) in patients with suspected or defined prostate cancer.In pilot study, we retrospectively investigated 62 who underwent PSMA-PET/MRI for PCa between June 2019 and 2020. Patients were grouped into three subgroups: (1) without histological evidence, (2) primary PCa, (3) biochemical recurrent cancer (BRPCa). Two nuclear physicians independently interpreted...

Urine culture is time consuming, which may take days to get the results and impede further timely treatment. Our objective evaluate whether fast urinalysis bacterial discrimination system called Sysmex UF-5000 predict urinary tract infections (UTIs) (within minutes) compared with clinical routine test in suspected UTI patients. In addition, we aimed explore accuracy of microbiologic information by UF-5000.Consecutive patients who were admitted from emergency department at Queen Mary Hospital...

To date, the combined effect of polygenic risk score (PRS) and prostate health index (phi) on PCa diagnosis in men undergoing biopsy has never been investigated. A total 3166 patients who underwent initial three tertiary medical centers from August 2013 to March 2019 were included. PRS was calculated basis genotype 102 reported East-Asian-specific variants. It then evaluated univariable or multivariable logistic regression models that internally validated using repeated 10-fold...

Early evidence is disputable for the effects of modifiable lifestyle behaviors on prostate cancer (PCa) risk. No research has yet appraised such causality in different ancestries using a Mendelian randomization (MR) approach.A two-sample univariable and multivariable MR analysis was performed. Genetic instruments associated with were selected based genome-wide association studies. Summary-level data PCa obtained from PRACTICAL GAME-ON/ELLIPSE consortia Europeans (79,148 cases 61,106...

Abstract Background Prostate health index ( phi ), a derivative of [−2]proPSA (p2PSA), has shown better accuracy than prostate‐specific antigen (PSA) in prostate cancer (PCa) detection. The present study was to investigate whether previously identified PSA‐associated single nucleotide polymorphisms (SNPs) influence p2PSA or levels and lead potential clinical utility. Methods We conducted an observational prospective with 2268 consecutive patients who underwent biopsy three tertiary medical...

Abstract Backgrounds: Urinary stone disease (USD, or urolithiasis) is common and poses a significant healthcare burden health economic in working-age population. We aim to provide epidemiological insights into the prevalence, incidence, trends, risk factors of USD among Chinese Methods: A prospective cohort study 966,481 participants from CHinese Electronic Records Research during 2009-2022 Yinzhou, China (CHERRY). Temporal trends were estimated by annual percentage changes (APC) using...

This study aimed to figure out whether the combination of prostate health index (PHI) and prostate-specific membrane antigen (PSMA)-PET/MR could improve diagnostic accuracy for cancer (PCa) than that each individual method used alone.

Abstract Systematic prostate biopsy has limitations, such as overdiagnosis of clinically insignificant cancer and underdiagnosis significant cancer. Magnetic resonance imaging (MRI)-guided biopsy, a promising alternative, might improve diagnostic accuracy. To compare the detection rates systematic combined (systematic plus MRI-targeted biopsy) in Asian men, we conducted retrospective cohort study men who underwent either or at two medical centers (Queen Mary Hospital Tung Wah Hospital, Hong...

Active surveillance/watchful waiting (AS/WW) is feasible and effective for favorable-risk prostate cancer (PCa). Understanding socioeconomic determinants of AS/WW may help determine the target population social support improve cancer-related survival.The Surveillance, Epidemiology, End Results Prostate with Watchful Waiting Database 18 Registries identified 229,428 adult men diagnosed primary localized PCa (clinical T1-T2c, N0M0) during a median follow-up 45 months between 2010 2016....

Telomerase reverse transcriptase (TERT) has been consistently associated with prostate cancer (PCa) risk. However, few studies have explored the association between TERT variants and PCa aggressiveness.Individual genetic data were obtained from UK Biobank a Chinese cohort (Chinese Consortium for Prostate Cancer Genetics).A total of 209,694 Europeans (14,550 cases/195,144 controls) 8873 (4438 cases/4435 involved. Nineteen susceptibility loci five novel ones (rs144704378, rs35311994,...

The genetic risk of aggressive prostate cancer (PCa) is hard to be assessed due the lack aggressiveness-related single-nucleotide polymorphisms (SNPs). Prostate volume (PV) a potential well-established factor for PCa, we hypothesize that polygenic score (PRS) based on benign hyperplasia (BPH) or PV-related SNPs may also predict PCa death.We evaluated PRS using 21 BPH/PV-associated SNPs, two established risk-related and 10 guideline-recommended hereditary genes in population-based UK Biobank...

Abstract The aim of liquid biopsies is to obtain tumor information via the molecular interrogation samples, including blood and urine. As a minimally invasive procedure, have attracted attention. A series studies reported associations biomarkers such as circulating DNA, cell-free DNA extracellular vesicles with urological cancers, especially prostate cancer (PCa), demonstrated promising potential biopsies. In this review, we summarize recent clinical translational in PCa other bladder renal...