A5013383146- Prostate Cancer Treatment and Research
- Lung Cancer Diagnosis and Treatment
- Cancer-related gene regulation
- Autophagy in Disease and Therapy
- Prostate Cancer Diagnosis and Treatment
- Renal cell carcinoma treatment
- RNA modifications and cancer
- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Urologic and reproductive health conditions
- Endoplasmic Reticulum Stress and Disease
- Protein Degradation and Inhibitors
- Antibiotics Pharmacokinetics and Efficacy
- Obstructive Sleep Apnea Research
- Phonocardiography and Auscultation Techniques
- Colorectal Cancer Surgical Treatments
- Inflammasome and immune disorders
- Tracheal and airway disorders
- Renal and related cancers
- Sirtuins and Resveratrol in Medicine
- Higher Education and Teaching Methods
- Thermal Regulation in Medicine
- Artificial Intelligence in Healthcare
- Antibiotic Resistance in Bacteria
- Salivary Gland Tumors Diagnosis and Treatment
Ruijin Hospital
2019-2024
Shanghai Jiao Tong University
2020-2024
Affiliated Hospital of Qingdao University
2018-2023
Qingdao University
2018-2023
Creative Commons
2023
Kunming General Hospital of Chengdu Military Command
2005-2016
Kunming Medical University
2011
Background: Methyltransferase-like 14 (METTL14) participates in tumorigenesis several malignancies, but how METTL14 mediates the metastasis of renal cell carcinoma (RCC) has never been reported. Methods: Western blotting, quantitative real-time PCR, and immunohistochemistry were used to determine mRNA protein levels relevant genes. Methylated RNA immunoprecipitation sequencing utilized screen potential targets METTL14. Chromatin assay for transposase-accessible chromatin performed...
BackgroundCell division cycle 20 (CDC20) is frequently overexpressed in malignant tumours and involved the differentiation process of hematopoietic stem cells. However, role CDC20 prostate cancer stem-like cells (CSCs) remains poorly understood.MethodsThe expression CDC20, CD44, β-catenin were examined specimens by immunohistochemistry assay, on properties CSCs was accessed real-time quantitive PCR, spheroid formation, vitro vivo limiting dilution assay.FindingCDC20 associated with...
Hypoxia-inducible factor 2α (HIF2α) antagonists are effective against clear cell renal carcinomas (ccRCCs) that highly express HIF2α. To identify potential drug targets in HIF2α low/− ccRCC, we constructed an epigenetic-focused single-guide RNA library and performed vivo CRISPR-Cas9 knockout screen BALB/c nude mice transplanted with 786-O (HIF2α high ) or Caki-2 cells. We found the m6A demethylase fat mass obesity-associated ( FTO gene was indispensable to growth of but not ccRCC. Activation...
Alveolar epithelial cell death plays a critical role in the pathogenesis of lipopolysaccharide (LPS)-induced acute lung injury. Increased autophagy has dual effect on survival. However, it is not known whether promotes or survival human alveolar cells exposed to LPS.Genetic and pharmacological approaches were used evaluate A549 viability upon LPS exposure. The endoplasmic reticulum (ER) stress unfolded protein response (UPR) pathways examined with immunoblotting studies further explore...
Single-cell RNA sequencing (scRNA-seq) was recently adopted for deciphering intratumoral heterogeneity across cell sub-populations, including clear renal carcinoma (ccRCC). Here, we characterized the single-cell expression profiling of 121 samples and found 44 metastasis-associated marker genes. Accordingly, trained validated 17 pivotal genes (MAGs) in 626 patients incorporating internal external cohorts to evaluate model predicting overall survival (OS) progression-free (PFS). Correlation...
Sunitinib is one of the multi-targeted tyrosine kinase inhibitors for treatment renal cell carcinoma (RCC) at present. However, its clinical efficacy limited by chemoresistance RCC. Our previous study found that eukaryotic translation initiation factor 3 subunit D (EIF3D) was an oncogene in development and progression RCC but little known about whether EIF3D participated sunitinib resistance RCC.The expression tumor tissue specimen detected immunohistochemistry. The effect on...
The aim of this study was to investigate the biological functions and underlying mechanisms SIRT5 in clear cell renal carcinoma (ccRCC).SIRT5 expression data Cancer Genome Atlas Kidney Clear Cell Carcinoma (TCGA-KIRC) were selected, correlations between various clinicopathological parameters analysed. ccRCC tissues examined using immunohistochemistry. Stable lines with knockdown established. In vitro vivo experiments conducted functional roles cellular biology ccRCC, including viability...
Objective To evaluate the impact of an enhanced recovery after surgery (ERAS) pathway on patients undergoing minimally invasive radical prostatectomy at a single institute. Methods In this retrospective study, 301 who underwent laparoscopic or robot-assisted from May 2014 to September 2018 were consecutively recruited. Before April 2017, treated with conventional care; all ERAS thereafter. The primary outcome was postoperative length hospital stay (LOS). secondary outcomes hospitalization...
Drowning is a cause of accidental mortality. However, survival may result in acute lung injury. The aim the present study was to evaluate effects 3,5,4'-tri-O-acetylresveratrol (AC-Res) on injury (ALI) induced by seawater inhalation rats. ALI models were established tracheal instillation artificial with or without 50 mg/kg AC-Res pretreatment for 7 days. Lung samples from different groups harvested 4 h after model established. Histological changes, blood vessel permeability, inflammatory...
This study aimed to evaluate the clinical utility of 18F-PSMA-1007 positron emission tomography (PSMA PET)/magnetic resonance imaging (MRI) in patients with suspected or defined prostate cancer.In pilot study, we retrospectively investigated 62 who underwent PSMA-PET/MRI for PCa between June 2019 and 2020. Patients were grouped into three subgroups: (1) without histological evidence, (2) primary PCa, (3) biochemical recurrent cancer (BRPCa). Two nuclear physicians independently interpreted...
Tubulocystic renal cell carcinoma is a rare neoplasm of kidney with low metastatic tendency. There has only been relatively small collection literature dedicated to this subtype. Here we present two cases diagnosed in our center detailed clinical information. Along review, aim paint comprehensive profile TC-RCC. Hematuria and asthenia could be the chief complaints although most patients are asymptomatic. This lesion signature multilocular cystic form on radiology enhancement septa should...
This study aimed to figure out whether the combination of prostate health index (PHI) and prostate-specific membrane antigen (PSMA)-PET/MR could improve diagnostic accuracy for cancer (PCa) than that each individual method used alone.
Antibiotics are emerging contaminants of concern worldwide, especially in coastal areas. However, no conclusion can confirm their ecotoxic effects based on popular employed biomarkers. Based our previous exploration the histopathological changes marine model organism-marine mussels, convincing results indicated sulfamethoxazole (SMX) induce tissue damage but examination procedure was labor- and time-consuming. In this study, a systematic working flow assessment developed, including...
In order to improve the operational efficiency of airport, wireless broadband communication technology will be used as an important airport surface in future. 2007, International Telecommunication Union (ITU) and Civil Aviation Organization (ICAO) proposed Aeronautical Mobile Airport Communication System (AeroMACS) [1]. This paper introduce AeroMACS, including its network architecture some application tests Hongqiao Airport, such vehicle monitoring, situation information display, video...
Asthma and chronic obstructive pulmonary disease (COPD) are the most common airway diseases, mainly manifested with inflammation affecting whole respiratory tract. Some studies have shown that two diseases can appeared at same time in partly patients, especially elderly known as asthma-chronic overlap syndrome (ACOS). Although incidence of ACOS is high, but it not well recognized, relevant clinical trial, patients asthma COPD often divided control group to make comparison. However, recent...
To the Editor: Sleeve resection, which is a procedure to resect and reconstruct bronchial and/or pulmonary arteries, considered valid therapeutic approach for centrally located lung cancer. With establishment development of comprehensive treatment concept, applying neoadjuvant such as immunotherapy against cancer with locally advanced staging effective. Neoadjuvant might reduce tumor size increase chances complete resection achieve parenchyma-sparing procedures sleeve resection. Generally,...
Vibration response imaging system is the important invention in this century,providing a dynamic objective basis for breathing disease diagnosis,chronic obstructive pulmonary has become global concern diseases,social burden heavier,so early diagnosis and treatment are particularly important.This paper vibration application of chronic latest summarized. Key words: Vibration imaging; Chronic disease; Diagnosis; Differential