A5024546037- Forensic and Genetic Research
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Genetic diversity and population structure
- Molecular Biology Techniques and Applications
- Genetic Associations and Epidemiology
- Genomics and Phylogenetic Studies
- Genetic and phenotypic traits in livestock
- Cancer-related gene regulation
- Circular RNAs in diseases
- RNA and protein synthesis mechanisms
- NF-κB Signaling Pathways
- Geoscience and Mining Technology
- Proteoglycans and glycosaminoglycans research
- Air Quality and Health Impacts
- RNA Research and Splicing
- MicroRNA in disease regulation
- Rheumatoid Arthritis Research and Therapies
- Glycosylation and Glycoproteins Research
- Hydrocarbon exploration and reservoir analysis
- Nicotinic Acetylcholine Receptors Study
- Cell Adhesion Molecules Research
- Ion channel regulation and function
- Blockchain Technology Applications and Security
Institute of Forensic Science
2015-2024
Chinese University of Hong Kong
2022-2024
City University of Hong Kong
2022-2024
University of California, San Francisco
2011-2023
Ministry of Public Security of the People's Republic of China
2015-2023
City of Hope
2023
Beckman Research Institute
2023
Zunyi Medical University
2023
Affiliated Hospital of North Sichuan Medical College
2023
Chinese Academy of Inspection and Quarantine
2018-2022
Abstract Background MicroRNAs (miRNAs) are involved in cancer development and progression, acting as tumor suppressors or oncogenes. Our previous studies have revealed that miR-148a miR-152 significantly down-regulated gastrointestinal cancers. Interestingly, miR-148b has the same "seed sequences" miR-152. Although aberrant expression of been observed several types cancer, its pathophysiologic role relevance to tumorigenesis still largely unknown. The purpose this study was elucidate...
Abstract Low n‐doping efficiency and inferior stability restrict the thermoelectric performance of n‐type conjugated polymers, making their lag far behind p ‐type counterparts. Reported here are two rigid coplanar poly( ‐phenylene vinylene) (PPV) derivatives, LPPV‐1 LPPV‐2 , which show nearly torsion‐free backbones. The fused electron‐deficient structures endow derivatives with less conformational disorder low‐lying lowest unoccupied molecular orbital (LUMO) levels, down to −4.49 eV. After...
BackgroundCell division cycle 20 (CDC20) is frequently overexpressed in malignant tumours and involved the differentiation process of hematopoietic stem cells. However, role CDC20 prostate cancer stem-like cells (CSCs) remains poorly understood.MethodsThe expression CDC20, CD44, β-catenin were examined specimens by immunohistochemistry assay, on properties CSCs was accessed real-time quantitive PCR, spheroid formation, vitro vivo limiting dilution assay.FindingCDC20 associated with...
Numerous studies indicate that non-coding RNAs (ncRNAs) have critical functions across biological processes, and single-nucleotide polymorphisms (SNPs) could contribute to diseases or traits through influencing ncRNA expression. However, the associations between SNPs expression are largely unknown. Therefore, genome-wide quantitative trait loci (eQTL) analysis assess effects of on expression, especially in multiple cancer types, will help understand how risk alleles toward tumorigenesis...
Abstract Global food trade has become an increasingly crucial element for feeding the world's population. Enhancing bilateral or multilateral trust in safety international is not only important promoting sustainable development of but also beneficial cooperation when facing a global crisis. However, highly credible traceability systems (TSs) cross‐border movement are still absent many countries and regions. Blockchain regarded as promising technology that can help build transparency security...
ancestor of monocots and eudicots.Expression data showed widespread distribution the cucumber LOX gene family within plant tissues, suggesting that they perform different functions in tissues.
Drug combination is now a hot research topic in the pharmaceutical industry, but experiment-based methodologies are extremely costly time and money. Many computational methods have been proposed to address these problems by starting from existing drug combinations. However, most cases, only molecular structure information included, which covers too limited set of characteristics efficiently screen Here, we integrated similarity-based multifeature data improve prediction accuracy using...
Abstract Agenesis of the corpus callosum (AgCC) is a congenital brain malformation that occurs in approximately 1:1,000–1:6,000 births. Several syndromes associated with AgCC have been traced to single gene mutations; however, majority causes remain unidentified. We investigated mother and two children who all shared complete chromosomal deletion at 1q42. fine mapped this show it includes Disrupted‐in‐Schizophrenia 1 ( DISC1 ), implicated schizophrenia other psychiatric disorders....
Small berry fruit products are gaining an expanded market due to their high nutrition value. However, the authenticity of is challenged by adulteration and mislabeling. To establish accurate robust method for identifying both known unknown species in small products, DNA barcoding technology based on Sanger sequencing was adopted. overcome influence processing conditions recovery, mini-barcodes rbcL ITS a medium-barcode psbA-trnH were applied. identify ingredients containing mixed species,...
Abstract Developing safe and effective therapeutic modalities remains a critical challenge for improving the prognosis of patients with colorectal cancer (CRC). In this regard, targeting epigenetic regulation in cancers has recently emerged as promising approach. Since several natural compounds have been shown to be important modulators, we hypothesized that Ginseng might exert its anticancer activity by regulating DNA methylation alterations CRC. study, series cell culture studies were...
Gastric cancer (GC) is one of the most commonly diagnosed malignancies, threatening millions lives worldwide each year. Importantly, GC a heterogeneous disease, posing significant challenge to selection patients for more optimized therapy. Over last decades, extensive community effort has been spent on dissecting heterogeneity GC, leading identification distinct molecular subtypes that are clinically relevant. However, so far, no tool publicly available subtype prediction, hindering research...
JZTX-XI is a peptide toxin isolated from the venom of Chinese spider Chilobrachys jingzhao. It contains 34 residues including six cysteine with disulfide bridges linked in pattern I-IV, II-V, and III-VI. Using 3'- 5'-RACE methods, full-length cDNA was identified as encoding an 86-residue precursor JZTX-XI. In electrophysiological assay, shows activity toward Kv2.1 channel way similar to hanatoxin1 SGTx1 that both activation deactivation processes are affected, which accordance high sequence...
Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic destructive inflammation in synovial joints. It well known that genetic and environmental risk factors their interaction contribute to RA pathogenesis. This study aimed investigate the association between critical polymorphisms tumor necrosis factor α (TNFα)-induced protein 3(TNFAIP3) gene of large northern Chinese Han population.A case-control 1280 patients matched healthy controls was conducted.This showed...
Abstract Background The reform of county-level public hospitals is a breakthrough in the new era healthcare China and has attracted considerable attention since 2012. Continuous efficient operations hospital are primary concerns this reform. To ensure effectiveness county-based intervention measures Chongqing, it significant to understand how county characteristics associated with efficiency due development differences between counties. This study identifies trajectory over time...