A5103201823- RNA modifications and cancer
- Migraine and Headache Studies
- Trigeminal Neuralgia and Treatments
- Cancer-related molecular mechanisms research
- Lipid metabolism and disorders
- RNA Research and Splicing
- Sympathectomy and Hyperhidrosis Treatments
- Lipid metabolism and biosynthesis
- Genomics and Chromatin Dynamics
- Cellular transport and secretion
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Pancreatic function and diabetes
- Multiple Sclerosis Research Studies
- Lipid Membrane Structure and Behavior
- Ferroptosis and cancer prognosis
- Peripheral Neuropathies and Disorders
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Erythrocyte Function and Pathophysiology
- Circular RNAs in diseases
- Plant Gene Expression Analysis
- Neurofibromatosis and Schwannoma Cases
- Plant-Microbe Interactions and Immunity
- Meningioma and schwannoma management
- Traumatic Brain Injury Research
- Immune cells in cancer
Huazhong Agricultural University
2019-2025
Southwest Forestry University
2024-2025
Peking Union Medical College Hospital
2022-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2025
Johns Hopkins Medicine
2024
Johns Hopkins University
2024
China-Japan Friendship Hospital
2021-2024
First Affiliated Hospital of Kunming Medical University
2023
Kunming Medical University
2023
Soochow University
2019-2021
Caveolae are bulb-shaped nanodomains of the plasma membrane that enriched in cholesterol and sphingolipids. They have many physiological functions, including endocytic transport, mechanosensing, regulation lipid transport. Caveola formation relies on integral proteins termed caveolins (Cavs) cavin family peripheral proteins. Both protein families bind anionic phospholipids, but precise roles these lipids unknown. Here, we studied effects phosphatidylserine (PtdSer), phosphatidylinositol...
Long non-coding RNAs (lncRNAs) act as versatile regulators of many biological processes and play vital roles in various diseases. lncRNASNP is dedicated to providing a comprehensive repository single nucleotide polymorphisms (SNPs) somatic mutations lncRNAs their impacts on lncRNA structure function. Since the last release 2018, there has been huge increase number variants lncRNAs. Thus, we updated version 3 by expanding species eight eukaryotic (human, chimpanzee, pig, mouse, rat, chicken,...
Numerous studies indicate that non-coding RNAs (ncRNAs) have critical functions across biological processes, and single-nucleotide polymorphisms (SNPs) could contribute to diseases or traits through influencing ncRNA expression. However, the associations between SNPs expression are largely unknown. Therefore, genome-wide quantitative trait loci (eQTL) analysis assess effects of on expression, especially in multiple cancer types, will help understand how risk alleles toward tumorigenesis...
Alternative polyadenylation (APA) is an important post-transcriptional regulation that recognizes different signals (PASs), resulting in transcripts with 3' untranslated regions, thereby influencing a series of biological processes and functions. Recent studies have revealed some single nucleotide polymorphisms (SNPs) could contribute to tumorigenesis development through dysregulating APA. However, the associations between SNPs APA human cancers remain largely unknown. Here, using genotype...
'Superbugs' have received increasing attention from researchers, such as ESKAPE bacteria (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter spp.), which directly led to about 1 270 000 death cases in 2019. Recently, phage peptidoglycan hydrolases (PGHs)-derived antimicrobial peptides were proposed new antibacterial agents against multidrug-resistant bacteria. However, there is still a lack of methods for...
Medicago sativa is an important forage crop; its value mainly concentrated in economic aspects. The growth cycle and rate of M. have influence on benefits. Alternaria alstroemeriae has often been used as a pathogenic bacterium previous studies, studies the growth-promoting effects A. are rare. This study aimed to assess parameters sativae investigate molecular metabolic mechanisms sativa. showed significant improvement plant height, root length, fresh weight, dry weight compared uninoculated...
Capsicum frutescens is a valuable economic crop that widely cultivated for its unique flavor and rich nutritional content. While some studies have shown differences in flavonoid content among different chili species, the mechanism by which changes composition lead to fruit color variations C. remains underreported. We performed transcriptomics targeted metabolome sequencing on three growth stages of analyzed data better understand change. Based previous research genes regulate compounds MBW...
Alternative promoter (AP) events, as a major pre-transcriptional mechanism, can initiate different transcription start sites to generate distinct mRNA isoforms and regulate their expression. At present, hundreds of thousands APs have been identified across human tissues, considerable number demonstrated be associated with complex traits diseases. Recent researches also proven important effects on animals. However, the landscape in animals has not fully recognized. In this study, 102,349 AP...
The identification of cancer prognostic biomarkers is crucial for predicting disease progression, optimizing personalized therapies, and improving patient survival. Molecular are increasingly being identified prognosis estimation. However, existing studies databases often focus on single-type molecular biomarkers, deficient in comprehensive multi-omics data integration, which constrains the exploration underlying mechanisms. To fill this gap, we conducted a systematic analysis using over...
This article reported a 33-year-old male electric welder with myelodysplastic syndrome (MDS) who presented recurrent fever. Laboratory tests revealed anemia, thrombocytopenia, elevated inflammatory markers, and positive blood cultures. Chest imaging examinations showed diffuse miliary nodules in both lungs, enlarged mediastinal lymph nodes, new patchy shadows the lungs. Antibacterial treatment was ineffective. Through video-assisted thoracoscopic surgery pathology, patient diagnosed...
Abstract Animal-ImputeDB (http://gong_lab.hzau.edu.cn/Animal_ImputeDB/) is a public database with genomic reference panels of 13 animal species for online genotype imputation, genetic variant search, and free download. Genotype imputation process estimating missing genotypes in terms the haplotypes panel. It can effectively increase density single nucleotide polymorphisms (SNPs) thus be widely used large-scale genome-wide association studies (GWASs) using relatively inexpensive low-density...
Parkinson's disease (PD) is a common, chronic, progressive, debilitating neurodegenerative disease. The current levodopa treatment requires the addition of other drugs, such as catechol-O-methyl transferase (COMT) inhibitors, to alleviate motor fluctuations in advanced PD. Therefore, theoretical reference for urgently needed. In this study, an appropriate search strategy was used screen eligible studies on different drugs treat patients with PD from Embase, PubMed, and Cochrane Library....
Objective: Gliomas are the most common primary tumors in central nervous system with a bad prognosis. Pyroptosis, an inflammatory form of regulated cell death, plays vital role progression and occurrence tumors. However, value pyroptosis related genes (PRGs) glioma remains poorly understood. This study aims to construct PRGs signature risk model explore correlation clinical characteristics, prognosis, tumor microenviroment (TME), immune checkpoints. Methods: RNA sequencing profiles relevant...
Enhancer RNAs (eRNAs) are a class of non-coding transcribed from enhancers. As the markers active enhancers, eRNAs play important roles in gene regulation and associated with various complex traits characteristics. With increasing attention to eRNAs, numerous have been identified different human tissues. However, expression landscape, regulatory network potential functions animals not fully elucidated. Here, we systematically characterized 185 177 5085 samples across 10 species by mapping...
Abstract Genotype imputation is a process that estimates missing genotypes in terms of the haplotypes and reference panel. It can effectively increase density single nucleotide polymorphisms (SNPs), boost power to identify genetic association promote combination studies. However, there has been lack high-quality panels for most plants, which greatly hinders application genotype imputation. Here, we developed Plant-ImputeDB (http://gong_lab.hzau.edu.cn/Plant_imputeDB/), comprehensive database...