A5054795296- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- RNA modifications and cancer
- RNA Research and Splicing
- Reproductive System and Pregnancy
- RNA Interference and Gene Delivery
- Antimicrobial Peptides and Activities
- Cancer-related gene regulation
- Cancer-related Molecular Pathways
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Endometriosis Research and Treatment
- Animal Virus Infections Studies
- Cell death mechanisms and regulation
- Immune Cell Function and Interaction
- Cancer Cells and Metastasis
- Renal and related cancers
- Pharmacological Effects of Natural Compounds
- interferon and immune responses
- Skin Protection and Aging
- Neurological Disease Mechanisms and Treatments
- Bacteriophages and microbial interactions
- Viral gastroenteritis research and epidemiology
- Monoclonal and Polyclonal Antibodies Research
Inner Mongolia Medical University
2025
Ocean University of China
2025
Qingdao National Laboratory for Marine Science and Technology
2025
South China Agricultural University
2025
Liaocheng University
2025
First Affiliated Hospital of Xi'an Jiaotong University
2021-2025
Northwestern Polytechnical University
2025
Fanjingshan National Nature Reserve
2025
University of Science and Technology of China
2025
Tianjin Medical University
2008-2024
Neutrophil extracellular traps (NETs) are intricate fibrous structures released by neutrophils in response to specific stimuli. These composed of depolymerized chromatin adorned with histones, granule proteins, and cytosolic proteins. NETs formed via two distinct pathways known as suicidal NETosis, which involves NADPH oxidase (NOX), vital is independent NOX. Certain proteins found within exhibit strong cytotoxic effects against both pathogens nearby host cells. While play a defensive role...
Abstract The nodal regulatory properties of microRNAs (miRNA) in metastatic cancer may offer new targets for therapeutic control. Here, we report that upregulation miR-483-5p is correlated with the progression human lung adenocarcinoma. promotes epithelial–mesenchymal transition (EMT) accompanied by invasive and Mechanistically, activated WNT/β-catenin signaling pathway exerts its prometastatic function directly targeting Rho GDP dissociation inhibitor alpha (RhoGDI1) leukocyte cell adhesion...
Abstract Atherosclerosis, a chronic inflammatory disease, is the major cause of life-threatening complications such as myocardial infarction and stroke. Endothelial apoptosis plays vital role in initiation progression atherosclerotic lesions. Although subset microRNAs (miRs) have been identified critical regulators atherosclerosis, studies on their participation endothelial atherosclerosis limited. In our study, we found that miR-26a expression was substantially reduced aortic intima ApoE...
A key cause of the high mortality cardiovascular diseases is cardiomyocyte inability to renew after cardiac injury. As a promising strategy supplement functional myocytes for repair, there pressing need understand cellular and molecular mechanisms heart regeneration.Seven genetic mouse lines were used: global OSM (oncostatin M) knockout, monocyte-/macrophage-specific deletion, cardiomyocyte-specific lines, including receptor gp130 (glycoprotein 130) activation, Yap (yes-associated protein)...
Abstract Objectives Micro RNA s (mi s) as small noncoding molecules function by regulating their target genes negatively. MiR‐1258 was widely researched in multicancers, but its role remains unclear colorectal cancer ( CRC ). Methods The expression of miR‐1258 and specific gene were detected human specimens cell lines mi RT ‐ PCR , qRT Western blot. effects on proliferation evaluated using CCK ‐8 assays, EdU incorporation, colony formation assays cell‐cycle assays; vitro the vivo...
FSTL1 is a protein coding gene associated with cell signaling pathway regulation and the progression of variety disorders. In this study, we hypothesized that increases oncogenesis in breast cancer by enhancing stemness chemoresistance. RT-PCR IHC revealed significantly higher mRNA levels TNBC than non-TNBC specimens lines. We then found were increased chemoresistant cells. LIVE/DEAD, MTT viability colony formation assays did fact demonstrate required for CDDP DOX chemoresistance...
Long non-coding RNA (lncRNA) plays an important role in many biological processes and has attracted widespread attention. Although the precise functions mechanisms for most lncRNAs are still unknown, we certain that usually perform their by interacting with corresponding RNA- binding proteins. For example, lncRNA-protein interactions play post transcriptional gene regulation, such as splicing, translation, signaling, advances complex diseases. However, experimental verification of prediction...
Abstract As the best substitute for antibiotics, antimicrobial peptides (AMPs) have important research significance. Due to high cost and difficulty of experimental methods identifying AMPs, more researches are focused on using computational solve this problem. Most existing calculation can identify AMPs through sequence itself, but there is still room improvement in recognition accuracy, a problem that constructed model cannot be universal each dataset. The pre-training strategy has been...
Objective— Thoracic aortic aneurysm and dissection (TAAD) are severe vascular conditions. Dysfunctional transforming growth factor-β (TGF-β) signaling in smooth muscle cells elevated angiotensin II (AngII) levels implicated the development of TAAD. In this study, we investigated whether these 2 factors lead to TAAD a mouse model explored possibility using microRNA-21 ( miR-21 ) for treatment Approach Results— was developed Smad3 (mothers against decapentaplegic homolog 3) heterozygous (S3...
Platelet-derived growth factor receptor (PDGFR) signaling is involved in proliferation and survival a wide array of cell types. The role PDGFR heart regeneration still unknown. We find that PDGFR-β decreases myocardium with age conditional activation cardiomyocytes promotes regeneration. Employing RNA sequencing, we show the enhancer zeste homolog 2 (Ezh2) can be upregulated by primary cardiomyocytes. Conditional knockout Ezh2 blocks cardiomyocyte H3K27me3 modification during neonatal...
Cisplatin is one of the most effective antitumor agents, but its clinical use highly limited by severe side effects, especially nephrotoxicity. Recently, active form gasdermin D (GSDMD), termed GSDMD-N, was identified to mediate pyroptotic inflammatory cell death in several diseases. However, role GSDMD-N fragment cisplatin-induced acute kidney injury (AKI) remains unclear. In present study, we found that pyroptosis induced cisplatin both mouse tissues and renal tubular epithelial cells,...
Abstract Background Amphibian-derived peptides exhibit considerable potential in the discovery and development of new therapeutic interventions for clinically challenging chronic skin wounds. MicroRNAs (miRNAs) are also considered promising targets effective therapies against However, further research this field is anticipated. This study aims to identify provide a peptide drug candidate, as well explore underlying miRNA mechanisms possible target wound healing. Methods A combination Edman...
Borrelia burgdorferi, the causative agent of Lyme disease, is transmitted to humans by bite Ixodes scapularis ticks. The mechanisms which bacterium from vector host are poorly understood. In this study, we show that F(ab)2 fragments BBE31, a B.burgdorferi outer-surface lipoprotein, interfere with migration spirochete tick gut into hemolymph during feeding. decreased infection results in lower salivary glands infection, and consequently attenuates mouse tick-transmitted B. burgdorferi. Using...
The present study aimed to investigate whether long non-coding RNAs (lncRNAs) are involved in cardiac fibrogenesis induced by myocardial infarction (MI). differentially expressed lncRNAs and mRNAs peri-infarct region of mice 4 weeks after MI were selected for bioinformatic analysis including gene ontology (GO) enrichment, pathway network analysis. Left ventricular tissue levels compared between sham control mice, using a false discovery rate (FDR) <5%. Out 55000 detected, 263...
MicroRNAs (miRNAs) play key roles in cancer development and progression. In the present study, we investigated role of miR-145 progression hepatocellular carcinoma (HCC). Ten HCC cell lines samples from 96 patients with were analyzed for expression by quantitative real-time polymerase chain reaction (qRT-PCR). Overexpression was established transfecting mimics into HepG2 QGY-7703 cells. Cell proliferation migration assessed viability assay transwell assay. Western blot to verify ROCK1 as a...
'Superbugs' have received increasing attention from researchers, such as ESKAPE bacteria (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter spp.), which directly led to about 1 270 000 death cases in 2019. Recently, phage peptidoglycan hydrolases (PGHs)-derived antimicrobial peptides were proposed new antibacterial agents against multidrug-resistant bacteria. However, there is still a lack of methods for...
Taurine, a conditionally essential amino acid, plays critical role in cardiovascular function.Here we examined the effect of taurine on mitochondria and endoplasmic reticulum rat cardiomyocytes during glucose deprivation (GD).Data showed that cell viability, intracellular contents, transporter expression were decreased GD.In contrast, an increase reactive oxygen species Ca 21 contents was observed.GD also caused disrupted mitochondrial membrane potential, apoptotic death, dissociation...