A5074810028- RNA modifications and cancer
- Tracheal and airway disorders
- S100 Proteins and Annexins
- Lung Cancer Research Studies
- ATP Synthase and ATPases Research
- Thermal Regulation in Medicine
- Metabolomics and Mass Spectrometry Studies
- Cancer-related molecular mechanisms research
- Salivary Gland Tumors Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- COVID-19 Clinical Research Studies
- Advanced Proteomics Techniques and Applications
- Inflammasome and immune disorders
- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Mass Spectrometry Techniques and Applications
- Biomarkers in Disease Mechanisms
- Ferroptosis and cancer prognosis
- Sirtuins and Resveratrol in Medicine
- Heme Oxygenase-1 and Carbon Monoxide
- Cancer Mechanisms and Therapy
- Machine Learning in Bioinformatics
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- MicroRNA in disease regulation
Air Force Medical University
2014-2024
Tang Du Hospital
2019-2023
Second Affiliated Hospital of Xi'an Jiaotong University
2008-2016
Xi'an Jiaotong University
2008-2010
Resveratrol is a plant-derived natural compound which possesses potential anticancer properties. However, there are scarce reports on its effects in non-small cell lung cancer and auxiliary function the of cisplatin. In present study, we investigated resveratrol viability apoptosis human H838 H520 lines. It has been found that inhibited proliferation cells dose- time-dependent manner, was increased treated with associated depolarization mitochondrial membrane potential, release cytochrome c...
Non-small cell lung cancer (NSCLC) accounts for 80-85% of all cases and the prognosis NSCLC patients is unsatisfactory since 5-year survival rate still as low 11%. Natural compounds derived from plants with few or no side effects have been recognized alternative auxiliary cure patients. Phloretin such an agent possessing various pharmacological activities; however, there scarce information on its anticancer NSCLC. It was evaluated confirmed, in present study, that phloretin inhibited...
The aim of the present research was to investigate protecting effects 3,5,4′‐tri‐O‐acetylresveratrol (AC‐Rsv) on LPS‐induced acute respiratory distress syndrome (ARDS). Lung injuries have been evaluated by histological examination, wet‐to‐dry weight ratios, and cell count protein content in bronchoalveolar lavage fluid. Inflammation assessed MPO activities cytokine secretion lungs cells. results showed that AC‐Rsv significantly reduced mortality mice stimulated with LPS. Pretreatment...
BackgroundEnhancing the diagnostic efficacy of early-stage lung cancer is crucial for improving prognosis. The objective this study was to ascertain dependable exosomal miRNAs as biomarkers diagnosis cancer.MethodsExosomal miRNA candidates were identified through sequencing and subsequently validated in various case-control sets using real-time quantitative reverse transcription-polymerase chain reaction (RT-qPCR). correlation between expression clinicopathological features investigated. To...
Inflammation takes responsibility for the seawater aspiration-induced lung injury. Tanshinone IIA (TIIA) can protect lipopolysaccharide-induced injury in mice through inhibition of inflammation, but it is not reported whether TIIA have a protective effect on induced by aspiration. Macrophage migration inhibitory factor (MIF) plays an important role acute In this study, we observed and MIF it. Seawater was aspirated into trachea rats to make model. administered investigate its beneficial...
Hypertension, as the most common comorbidity for patients with coronavirus disease 19 (COVID-19), has resulted in cases more severe symptoms and higher mortality. The risk factors associated COVID-19 hypertension are unknown.All available confirmed from February 3 to March 10, 2020, were enrolled Huoshenshan Hospital, Wuhan, China. demographic characteristics, clinical manifestations, laboratory data, radiological assessments, treatments on admission extracted compared. Univariate...
Icariin (ICA), a major constituent of flavonoids from the Chinese medical herb Epimedium brevicornum Maxim, is found to be protective for male reproductive ability, with underlying mechanism largely unknown. Our study here investigated effects ICA on Sertoli cells, which act as nurse cells germ developing. was stimulate cell proliferation in dose-dependent manner. Further revealed that induced an obvious phosphorylation ERK cells. Inhibition activation by inhibitor U0126 nearly blocked...
The aim of the present study was to examine effects 3,5,4'-tri-O-acetylresveratrol on connexin 43 (Cx43) in acute lung injury (ALI) rats induced by tracheal instillation artificial seawater. Different doses (50, 150, and 450 mg/kg) were administered orally for 7 days before modeling. Four hours after seawater inhalation, histological changes, contents TNF- α , IL-1 β IL-10, expression Cx43 lungs detected. Besides, gap junction communication A549 cells human umbilical vein endothelial...
A specific protein profile that accompanies neoplastic transformation in the premalignant airway epithelium could provide an opportunity for early diagnosis of lung cancer. The aim this study was to screen and identify candidate biomarkers non-small cell Thirteen cancer samples were obtained within 30 minutes after a surgical resection. Laser capture microdissection performed enrich normal squamous metaplasia or atypical adenomatous hyperplasia populations. resulting tandem mass spectrum...
ABSTRACT Purpose One major issue is the therapeutic effect following chemotherapy for non–small cell lung cancer (NSCLC). Although numerous risk factors have been identified and novel therapies developed, improving patient overall survival (OS) remains a crucial postoperative issue. This study aimed to develop nomogram accurately predicting OS of patients with Stage III–IV NSCLC treated chemotherapy. Methods The Department Respiration at Tangdu Hospital, Air Force Medical University,...
Abstract Background The purpose of this study is to discover potential biomarkers in serum for the detection small cell lung cancer (SCLC). Methods 74 samples including 30 from SCLC patients and 44 healthy controls were analyzed using ClinProt system combined with matrix-assisted laser desorption/ionization time-of-flight masss spectrometry (MALDI-TOF-MS). software genetic algorithm analysis selected a panel markers that most efficiently predicted which had SCLC. Results diagnostic pattern 5...
Previous studies show that overexpression of stathmin involved in the malignant biological behavior lung cancer. This investigation is to disclose expression status non-small cell cancer (NSCLC) and its clinical value for diagnosis prognosis cancer.The cells tissues NSCLC was examined using immunohistochemistry (IHC), in-situ hybridization (ISH), Western blot. The correlation between survival patients evaluated by a Kaplan-Meier method multiple regression analysis.NSCLC showed an compared...
Drowning is a cause of accidental mortality. However, survival may result in acute lung injury. The aim the present study was to evaluate effects 3,5,4'-tri-O-acetylresveratrol (AC-Res) on injury (ALI) induced by seawater inhalation rats. ALI models were established tracheal instillation artificial with or without 50 mg/kg AC-Res pretreatment for 7 days. Lung samples from different groups harvested 4 h after model established. Histological changes, blood vessel permeability, inflammatory...
Background: Tracheobronchopathia osteochondroplastica (TO) is a benign rare disease characterized by multiple tracheobronchial nodules, which has not been clearly illuminated and there are no standard guidelines for TO management. The aim of this study was to clarify the clinical features treatment outcomes provide basis diagnosis treatment. Methods: A total 32,215 patients taken bronchoscopy were retrospectively reviewed select diagnosed with TO. Clinical characteristics, bronchoscopic...
To identify the risk factors for predicting dynamic progression of COVID-19.A total 2321 eligible patients were included in this study from February 4 to April 15, 2020. Two illness conditions, including mild/moderate (M/M) subtype severe/critical (S/C) and S/C fatality, classified. Clinical message was collected compared, respectively. Kaplan-Meier method, Cox regression model score system used predict disease 112 1761 with M/M progressors (P) 1649 non-progressors (NP). Increasing...