A5101997857- Liver Disease Diagnosis and Treatment
- Inflammatory Biomarkers in Disease Prognosis
- Diet and metabolism studies
- Liver Disease and Transplantation
- Maternal Mental Health During Pregnancy and Postpartum
- Child and Adolescent Psychosocial and Emotional Development
- Endoplasmic Reticulum Stress and Disease
- Fatty Acid Research and Health
- Gut microbiota and health
- Ferroptosis and cancer prognosis
- Autophagy in Disease and Therapy
- Liver Diseases and Immunity
- Spinal Cord Injury Research
- Electrocatalysts for Energy Conversion
- Family and Disability Support Research
- Liver physiology and pathology
- Plant-based Medicinal Research
- Technology and Data Analysis
- Dietary Effects on Health
- Piperaceae Chemical and Biological Studies
- COVID-19 and Mental Health
- Colorectal and Anal Carcinomas
- Spinal Dysraphism and Malformations
- Functional Brain Connectivity Studies
- Child Abuse and Trauma
Southern Medical University
2023-2025
The First People's Hospital of Shunde
2023-2025
117th Hospital of People's Liberation Army
2024-2025
Taizhou First People's Hospital
2025
Chinese People's Liberation Army
2025
Nanjing Medical University
2023-2025
Jiangsu Province Hospital
2025
Huazhong University of Science and Technology
2017-2024
Union Hospital
2017-2024
Children's Hospital of Zhejiang University
2024
Deoxynivalenol (DON) is a widespread issue for feed and food safety, leading to animal human health risks. The objective of this study was determine whether ferroptosis involved in DON-induced intestinal injury piglets. Three groups 21-day-old male weanling piglets (n = 7/group) were fed control diet, or diet adding 1.0 3.0 mg DON/kg. At week 4, serum small intestines collected assay biochemistry, histology, redox status ferroptosis-related genes expression. In addition, the involvement role...
The relationship between systemic inflammation and tumor-associated bacteria is largely unknown in colorectal cancer (CRC). primary aim of this study was to investigate the prognostic effects response index (SIRI) on survival outcomes CRC patients who experienced surgical therapy, second reveal potential association SIRI levels CRC. We recruited a cohort 298 resection Wuhan Union Hospital. These were assigned low high groups based cut-off value SIRI. utilized 1:1 propensity score matching...
Ferroptosis, a newly characterized form of regulated cell death, is induced by excessive accumulation lipid peroxidation catalyzed intracellular bioactive iron. Increasing evidence has suggested that ferroptosis involved in the pathogenesis several human diseases, including acute liver injury. Targeted inhibition holds great promise for clinical treatment these diseases. Herein, we report simple and one-pot synthesis ultrasmall poly(acrylic) acid coated Mn3O4 nanoparticles (PAA@Mn3O4-NPs,...
Our recent studies have shown that hypothermic microenvironment promotes tumor progression and the molecular sensors for cold are transient receptor potential (TRP) channels TRPM8 TRPA1. To evaluate contribution of TRPA1 to cancer malignancy, we screened cell subpopulations from Lewis lung (LLC) using limiting dilutions Western blotting. We identified LLC-1 cells express 3-fold more than TRPA1, LLC-2 at levels similar LLC-3 one-third level showed greater adhesion, migration, invasiveness...
The oxygen reduction reaction (ORR) plays an irreplaceable role in many energy-conversion processes. Low-cost catalysts with high activity and stability are eagerly needed to improve the sluggish ORR kinetics. Herein, we use a simple hydrothermal method evenly deposit iron disulfide (FeS2, as shell) on surface of dodecahedral Co@N-doped graphitized carbon (Co@DNC, core) ZIF-67 dodecahedrons precursor. Co@DNC@FeS2-0.5 (Co@DNC-to-FeCl3¡6H2O mass ratio 0.5) catalyst shows comparable catalytic...
Both gingerol and capsaicin are agonists of TRPV1, which can negatively control tumor progression. This study observed the long-term effects oral administration 6-gingerol alone or in combination with for 20 weeks a urethane-induced lung carcinogenic model. We showed that carcinoma incidence multiplicity were 70% 21.2 Âą 3.6, respectively, versus 100% 35.6 5.2 group (P < 0.01) 50% 10.8 3.1 0.01). The reversed cancer-promoting effect (carcinoma 20% 4.7 2.3; P 0.001). was due to increased...
This study explores the contributions of neutrophils to chemotherapeutic resistance and berberine-regulated cancer cell sensitivity doxorubicin (DOX). In vitro experiments, continuous DOX treatment led shift HL-60 cells N2 thus induced resistance. The combination with 2 ÂľM berberine resulted in differentiation toward N1 therefore stimulated immune clearance. Berberine increased reactive oxygen species (ROS) decreased autophagy apoptosis HL-60-N2 morphological changes, but had no effect on...
Resolvin D1 (RvD1) was previously reported to relieve inflammation and liver damage in several diseases, but its potential role fibrosis remains elusive. The aim of our study investigate the effects underlying mechanisms RvD1 hepatic autophagy fibrosis. In vivo , male C57BL/6 mice were intraperitoneally injected with 20% carbon tetrachloride (CCl4, 5 ml/kg) twice weekly for 6 weeks establish model. (100 ng or 300 ng/mouse) added daily last 2 modeling period. vitro lipopolysaccharide...
Smoke bombs are often used in military/fire training, which can produce a large amount of zinc chloride (ZnCl2) smoke. Inhalation ZnCl2 smoke usually causes acute lung injury (ALI) that would likely develop to respiratory distress syndrome (ARDS). However, there is no effective prevention or treatment strategy for the smoke-induced ALI. Resveratrol (RES) natural polyphenol with good anti-inflammatory and anti-apoptotic activities, but its low solubility, stability, bioavailability restrict...
Dedifferentiated liposarcoma (DDLPS) is a subtype of LPS characterized by two distinct levels differentiation and morphological structures, comprising areas wellâdifferentiated dedifferentiated, nonâlipogenic, highly malignant components. DDLPS most frequently occurs in the retroperitoneum soft tissues pelvis limbs, rare head neck region, accounting for only 1% sarcomas. The present study describes case 72âyearâold male with 30âyear history left upper limb numbness heaviness. During physical...
Exercise is an effective non-pharmacological strategy to enhance cognitive function in individuals with mild impairment (MCI). Our previous studies confirmed that aerobic dance can increase the amplitude of low-frequency fluctuations (LFF) bilateral fronto-temporal, entorhinal, anterior cingulate, and para-hippocampal cortices. However, its effects on structural connections remain unclear. The present study comprised a secondary analysis randomized clinical trial aimed examine impact 3-month...
Ferroptosis is a newly characterized form of programmed cell death. The fundamental biochemical feature ferroptosis the lethal accumulation iron-catalyzed lipid peroxidation. It has gradually been recognized that implicated in pathogenesis variety human diseases. Increasing evidence shed light on regulation by amino acid metabolism. Herein, we report arginine deprivation potently inhibits erastin-induced ferroptosis, but not RSL3-induced several types mammalian cells. Arginine presence...
Background Microbial infection is accompanied by remodeling of the host transcriptome. Involvement A-to-I RNA editing has been reported during viral but remains to be elucidated intracellular bacterial infections. Results Herein we analyzed infections based on 18 RNA-Seq datasets 210 mouse samples involving 7 tissue types and 8 pathogens (IBPs), identified a consensus signature for IBP infections, mainly neutrophil-mediated innate immunity lipid metabolism. Further comparison patterns...
Inflammation takes responsibility for the seawater aspiration-induced lung injury. Tanshinone IIA (TIIA) can protect lipopolysaccharide-induced injury in mice through inhibition of inflammation, but it is not reported whether TIIA have a protective effect on induced by aspiration. Macrophage migration inhibitory factor (MIF) plays an important role acute In this study, we observed and MIF it. Seawater was aspirated into trachea rats to make model. administered investigate its beneficial...