A5101743626- Venomous Animal Envenomation and Studies
- Cancer therapeutics and mechanisms
- Biochemical and Structural Characterization
- Mitochondrial Function and Pathology
- Bioactive Compounds and Antitumor Agents
- Ion channel regulation and function
- Cellular Mechanics and Interactions
- S100 Proteins and Annexins
- Traumatic Brain Injury and Neurovascular Disturbances
- Single-cell and spatial transcriptomics
- Neutropenia and Cancer Infections
- High Altitude and Hypoxia
- Neuroinflammation and Neurodegeneration Mechanisms
- Virus-based gene therapy research
- Neuroscience of respiration and sleep
- Endoplasmic Reticulum Stress and Disease
- Cell Image Analysis Techniques
- Advanced biosensing and bioanalysis techniques
- Hippo pathway signaling and YAP/TAZ
- Neuroscience and Neuropharmacology Research
- RNA Interference and Gene Delivery
- Signaling Pathways in Disease
- Intensive Care Unit Cognitive Disorders
- Cell death mechanisms and regulation
- Lung Cancer Research Studies
Gansu University of Traditional Chinese Medicine
2025
Guangdong Pharmaceutical University
2024
Soochow University
2015-2024
Beijing Radiation Center
2024
University of Minnesota
2023
Zhangjiagang First People's Hospital
2015-2023
Guizhou University
2021-2023
University of South China
2022-2023
Inner Mongolia Medical College Hospital
2022
Hunan Agricultural University
2021-2022
Luotonin A is a pyrroloquinazolinoquinoline alkaloid isolated from the Chinese herbal medicinal plant Peganum nigellastrum. Although previously shown to exhibit cytotoxicity against murine leukemia P-388 cell line, mechanism of action luotonin unknown. Presently, we demonstrate that stabilizes human DNA topoisomerase I−DNA covalent binary complex, affording same pattern cleavage as structurally related I inhibitor camptothecin. also mediated I-dependent toward Saccharyomyces cerevisiae...
On the basis of an analysis luotonin A and its D-ring deaza analogue as topoisomerase I poisons I-dependent cytotoxic agents, a novel structurally related antitumor antibiotic camptothecin (CPT) was prepared. 14-Azacamptothecin found to have much greater aqueous solubility than CPT, inhibit I-mediated DNA relaxation more efficiently stabilize covalent binary complex almost same extent. 14-Aza CPT be slightly less active in mediating cytotoxicity toward yeast expressing human I, possibly...
Lung fibrosis is associated with inflammation, apoptosis and oxidative damage. The transcription factor nuclear erythroid 2‑related factor‑2 (Nrf2) prevents damage to cells from stress by regulating the expression of antioxidant proteins. Sulforaphane (SFN), an Nrf2 activator, additionally regulates excessive promoting endogenous antioxidants. present study investigated if SFN protects against lung injury induced bleomycin (BLM). secondary aim was assess this protection mechanism involves...
Background and objectives Acute mountain sickness (AMS) is a pathology with different symptoms in which the organism not adapted to environment that occurs under special of high altitude. Its main mechanism organism’s tissue damage caused by acute hypobaric hypoxia. Traditional Chinese medicine (TCM) theory focuses on holistic concept. TCM has made remarkable achievements treatment many sicknesses. This review outlines pathogenesis AMS modern traditional medicine, progress animal models AMS,...
Due to the growth of e-commerce and increasing demand for eco-friendly consumption, green supply chain has received significant attention recently. Additionally, delivery time products can significantly impact market in online channel. However, due incomplete historical data, epistemic uncertainty will inevitably arise when estimating products. Therefore, by applying theory, we propose an uncertain function based on greenness time, thus introducing into comprising platform a manufacturer....
Dedifferentiated liposarcoma (DDLPS) is a subtype of LPS characterized by two distinct levels differentiation and morphological structures, comprising areas well‑differentiated dedifferentiated, non‑lipogenic, highly malignant components. DDLPS most frequently occurs in the retroperitoneum soft tissues pelvis limbs, rare head neck region, accounting for only 1% sarcomas. The present study describes case 72‑year‑old male with 30‑year history left upper limb numbness heaviness. During physical...
Neuroinflammation plays an important role in secondary injury after traumatic brain (TBI). Andrographolide (Andro), a diterpenoid lactone isolated from Andrographis paniculata, has been demonstrated to exhibit anti-inflammatory activity neurodegenerative disorders. This study therefore aimed investigate the potential neuroprotective effects of Andro TBI and explore underlying mechanisms. In our study, we used weight-dropped model induce Sprague-Dawley rats, neurological deficits were...
Ubiquitin-specific protease 11 (USP11) is a ubiquitin-specific involved in the regulation of protein ubiquitination. However, its role traumatic brain injury (TBI) remains unclear. This experiment suggests that USP11 possibly regulating neuronal apoptosis TBI. Therefore, we use precision impactor device to established TBI rat model and assayed by overexpressing inhibiting USP11. We found Usp11 expression increased after In addition, hypothesized pyruvate kinase M2 (PKM2) potential target...
Armcx1 is a member of the ARMadillo repeat-Containing protein on X chromosome (ARMCX) family, which recognized to have evolutionary conserved roles in regulating mitochondrial transport and dynamics. Previous research has shown that expressed at higher levels mice after axotomy adult retinal ganglion cells crush injury, this increases neuronal survival axonal regeneration. However, its role traumatic brain injury (TBI) unclear. Therefore, aim study was assess expression TBI explore possible...
We conducted a meta-analysis of observational studies to examine the hypothesized association between breast cancer and antihypertensive drug (AHT) use. Fixed- or random- effect models were used calculate pooled risk ratios (RRs) 95% confidence intervals (CIs) for all AHTs individual classes (i.e., angiotensin-converting enzyme inhibitors, [ACEi]; angiotensin-receptor blockers, [ARBs]; calcium channel [CCBs]; beta-blockers, [BBs], diuretics). Twenty-one with 3,116,266 participants included....