A5042080483- Genetic Associations and Epidemiology
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Advanced biosensing and bioanalysis techniques
- Epigenetics and DNA Methylation
- Lymphoma Diagnosis and Treatment
- Systemic Lupus Erythematosus Research
- Genomics and Chromatin Dynamics
- RNA Research and Splicing
- Ferroptosis and cancer prognosis
- Traumatic Brain Injury and Neurovascular Disturbances
- Glaucoma and retinal disorders
- Genetic and phenotypic traits in livestock
- Genetic Mapping and Diversity in Plants and Animals
- S100 Proteins and Annexins
- Neuroinflammation and Neurodegeneration Mechanisms
- Ion channel regulation and function
- Rheumatoid Arthritis Research and Therapies
- Intraocular Surgery and Lenses
- Immune Response and Inflammation
- Gene expression and cancer classification
- Immune cells in cancer
- Genetic Syndromes and Imprinting
- T-cell and B-cell Immunology
- Hearing, Cochlea, Tinnitus, Genetics
Nanjing Drum Tower Hospital
2021-2025
Obstetrics and Gynecology Hospital of Fudan University
2024-2025
Nanjing Medical University
2022-2025
Zhongkai University of Agriculture and Engineering
2023-2025
Jiangsu Cancer Hospital
2022-2025
Xi'an Jiaotong University
2010-2024
Changzhi Medical College
2024
Zhangjiagang First People's Hospital
2018-2024
Soochow University
2010-2024
Shandong University of Technology
2022-2024
Chemical looping combustion (CLC) is a new technology that clean and highly efficienct. The reactivity of four potential oxygen carrier particles composed Fe2O3/CuO MgAl2O4 have been investigated using thermogravimetric analysis (TGA) laboratory pressurized circulating fluidized bed system. According to the research, following findings can be made: first, consisting 45% Fe2O3 15% CuO supported on 40% (F45C15M40) were found best for CLC coke oven gas (COG). Secondly, results multicycle...
Astrocyte activation is a hallmark of central nervous system injuries resulting in glial scar formation (astrogliosis). The astrocytes involves metabolic and morphological changes with complex underlying mechanisms, which should be defined to provide targets for astrogliosis intervention. Astrogliosis usually accompanied by an upregulation fibrillary acidic protein (GFAP). Using vitro scratch injury model, we scratched primary cultures cerebral cortical observed influx calcium the form waves...
Even with sufficient oxygen, tumor cells use glycolysis to obtain the energy and macromolecules they require multiply, once thought be a characteristic of known as "Warburg effect". In fact, throughout process carcinogenesis, immune stromal cells, two major cellular constituents microenvironment (TME), also undergo thorough metabolic reprogramming, which is typified by increased glycolysis. this review, we provide full-scale review glycolytic remodeling several types TME show how these...
Childhood obesity is reported to be associated with the risk of many diseases in adulthood. However, observational studies cannot fully account for confounding factors. We aimed systematically assess causal associations between childhood body mass index (BMI) and various adult traits/diseases using two-sample Mendelian randomization (MR).After data filtering, 263 traits genetically correlated BMI (P < 0.05) were subjected MR analyses. Inverse-variance weighted, MR-Egger, weighted median,...
Abstract The synovium is an important component of any synovial joint and the major target tissue inflammatory arthritis. However, multi-omics landscape required for functional inference absent from large-scale resources. Here we integrate genomics with transcriptomics chromatin accessibility features human in up to 245 arthritic patients, characterize genetic regulation on gene expression regulatory mechanisms mediating diseases predisposition. We identify 4765 independent primary 616...
The domestic silkworm, Bombyx mori, is a model insect with important economic value for silk production that also acts as bioreactor biomaterial production. functional complexity of the silkworm transcriptome has not yet been fully elucidated, although genomic sequencing and other tools have widely used in its study. We explored at different developmental stages using high-throughput paired-end RNA sequencing. A total about 3.3 gigabases (Gb) sequence was obtained, representing 7-fold...
Childhood asthma ranks among the prevailing chronic respiratory conditions affecting a significant number of individuals. The long-term hypoxic state and inflammatory caused by could be linked with spermatozoa apoptosis. However, correlation between childhood abnormal is currently unknown. In our study, method two-sample Mendelian randomization (2SMR) was used searching an appropriate European population genome-wide association studies (GWAS) database from Ieu Open GWAS Project database....
Lung adenocarcinoma (LUAD) is one of the most common tumors in terms incidence and mortality worldwide. Posttranslational modifications, including crotonylation, play a crucial role various biological processes diseases. However, crotonylation LUAD remains unclear. Our research focuses on identifying key genes that are linked to prognosis. We also aim clarify their microenvironment advance clinical translation related targets. used RNA-sequencing data from The Cancer Genome Atlas (TCGA)...
Previous studies have demonstrated that lifestyle was associated with myopia. This study used Mendelian randomization (MR) analysis to examine the causal relationships between time of computer use, outdoors in summer and winter Subsequently, univariate MR (UVMR) analyses were carried out respectively on three exposure factors myopia, results mainly based inverse-variance-weighted method. In addition, sensitivity also conducted, including heterogeneity tests, horizontal pleiotropy...
<title>Abstract</title> Background HIV remains a critical global public health challenge, with 39 million people living as of 2022 and over 40.4 lives lost to the epidemic. In China, burden is similarly significant, 1.33 cases reported 2024. The challenges are particularly acute in western regions like Yunnan Province, which face resource limitations, socio-demographic disparities, high prevalence among ethnic minorities. Objectives This study examines HIV/AIDS diagnosis, treatment,...
Neuroinflammation plays an important role in secondary injury after traumatic brain (TBI). Andrographolide (Andro), a diterpenoid lactone isolated from Andrographis paniculata, has been demonstrated to exhibit anti-inflammatory activity neurodegenerative disorders. This study therefore aimed investigate the potential neuroprotective effects of Andro TBI and explore underlying mechanisms. In our study, we used weight-dropped model induce Sprague-Dawley rats, neurological deficits were...
Waxy corn has a short growth cycle and high multiple cropping index. However, after being planted in early spring, late autumn winter, it is susceptible to low temperature (LT), which reduces the emergence rate yield. Therefore, important analyze response mechanism of waxy under LT stress.All phenotype indexes inbred lines N28 were significantly higher than N67 LT. With increase stress time, all physiological showed an upward trend N67. Differentially expressed genes (DEGs) 16,017 14,435...
Water movement plays vital roles in both physiological and pathological conditions the brain. Astrocytes are responsible for regulating this water major contributors to brain edema conditions. Aquaporins (AQPs) astrocytes play critical regulation of AQP1, 3, 4, 5, 8, 9 have been reported Compared with 9, AQP3, 8 less studied. Among lesser known AQPs, AQP5, which has multiple functions identified outside central nervous system, is also indicated be involved hypoxia injury astrocytes. In our...
The present study investigates the effects of Juglans regia L. (walnut, JRL) leaves extract on osteogenesis human bone marrow mesenchymal stem cells (hBMSCs).hBMSCs were incubated with different concentrations JRL (10, 20, 40, or 80 μM). Cell proliferation was evaluated by Counting Kit-8 assay (CCK-8) assay. ALP activity and Alizarin Red staining used to assess BMSCs. Western blot performed measure levels proteins.Our results showed all had no significant effect cell proliferation....
Abstract Nearly 95% of susceptibility SNPs identified by genome-wide association studies (GWASs) are located in non-coding regions, which causes a lot difficulty deciphering their biological functions on disease pathogenesis. Here, we aimed to conduct comprehensive functional annotation for all the schizophrenia loci obtained from GWASs. Considering varieties epigenomic regulatory elements, annotated 22,688 acquired according genomic positions obtain SNPs. The indicated that these broadly...