A5100332374- MicroRNA in disease regulation
- Immunotherapy and Immune Responses
- Extracellular vesicles in disease
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Cancer Immunotherapy and Biomarkers
- RNA Interference and Gene Delivery
- RNA modifications and cancer
- Liver Disease Diagnosis and Treatment
- Gut microbiota and health
- Autophagy in Disease and Therapy
- Peroxisome Proliferator-Activated Receptors
- CAR-T cell therapy research
- Cancer-related Molecular Pathways
- Heat shock proteins research
- Cancer, Hypoxia, and Metabolism
- Connexins and lens biology
- Photodynamic Therapy Research Studies
- Nanoplatforms for cancer theranostics
- Pancreatic and Hepatic Oncology Research
- Cancer Mechanisms and Therapy
- Hepatocellular Carcinoma Treatment and Prognosis
- Immune Cell Function and Interaction
- Redox biology and oxidative stress
- Rice Cultivation and Yield Improvement
Fudan University
2006-2025
Beijing Children’s Hospital
2024
Capital Medical University
2024
Nanjing Medical University
2013-2024
Jiangsu Province Hospital
2015-2024
Affiliated Hospital of Nantong University
2019-2024
Nantong University
2019-2024
Nanjing Normal University
2024
Xuzhou Medical College
2023
Jiangsu University
2023
Abstract Objective Hepatocellular carcinima is one of the most common tumors in clinic and also leading causes death from cancer worldwide. Quercetin shows significant effects on blocking development various cancers. Methods We used human hepatocellular carcinoma LM3 nude mice tumor model to assess quercetin clarify its mechanism action. collected cell line treated with different doses at time periods determined vital indexes. The liver tissues were for western boltting (WB), Hematoxylin...
The PD-1 pathway, consisting of the co-inhibitory receptor on T cells and its ligand (PD-L1) antigen-presenting (APCs), is a major mechanism tumor immune evasion. PD-L1 blockade antibodies have produced remarkable clinical activities against subset cancers. Binding between cell-intrinsic APC-intrinsic triggers inhibitory signaling to attenuate cell response. Here, we report that co-expressed with tumor-infiltrating APCs. Using reconstitution culture assays, demonstrate binds in cis. Such...
// Jie Ji 1, * , Junwei Tang Lei Deng Yu Xie 1 Runqiu Jiang Guoqiang Li Beicheng Sun Liver Transplantation Center of the First Affiliated Hospital and Collaborative Innovation For Cancer Personalized Medicine, Nanjing Medical University, Nanjing, Jiangsu Province, P.R. China These authors have contributed equally to this work Correspondence to: Sun, e-mail: sunbc@njmu.edu.cn Keywords: lncRNA, HCC, EpCAM, mTOR, prognosis Received: April 27, 2015 Accepted: October 16, Published: 26, ABSTRACT...
Enzymatically inactive chitinase-like protein CHI3L1 drives inflammatory response and promotes tumor progression. However, its role in gastric cancer (GC) tumorigenesis metastasis has not yet been fully elucidated. We determined the significance of expression patients with GC. also explored an as-yet unknown receptor investigated involved signaling GC metastasis.CHI3L1 was evaluated by immunoblotting, tissue microarray-based immunohistochemistry analysis (n = 100), enzyme linked...
Even with sufficient oxygen, tumor cells use glycolysis to obtain the energy and macromolecules they require multiply, once thought be a characteristic of known as "Warburg effect". In fact, throughout process carcinogenesis, immune stromal cells, two major cellular constituents microenvironment (TME), also undergo thorough metabolic reprogramming, which is typified by increased glycolysis. this review, we provide full-scale review glycolytic remodeling several types TME show how these...
// Xiaojie Wang 1, * , Jie Ji Haiyan Zhang 1 Zhixia Fan Linglin Lei Shi Feifan Zhou 2 Wei R. Chen 2, Hongwei 3 Xiuli Shanghai Skin Disease Hospital, 200443, China Biophotonics Research Laboratory, Center for Interdisciplinary Biomedical Education and Research, University of Central Oklahoma, Edmond, OK 73034, USA Huadong Fudan University, 200040, These authors have contributed equally to this work Correspondence to: Wang, e-mail: wangxiuli20150315@163.com hongweiwang2005@aliyun.com Keywords:...
Immune checkpoint blockade (ICB) is a powerful oncologic treatment modality for wide variety of human malignancies, but the patient response rate to this remains low, especially in patients with cutaneous squamous cell carcinoma (cSCC). 5-Aminoleuvulinic acid-photodynamic therapy (ALA-PDT) widely used treat cancerous and precancerous skin diseases, value ALA-PDT invasive cSCC debatable. Our previous studies have shown that can induce antitumor immune responses by promoting immunogenic death...
// Jie Ji 1, * , Zhixia Fan Feifan Zhou 2 Xiaojie Wang 1 Lei Shi Haiyan Zhang Peiru Degang Yang Linglin Wei R. Chen 2, Xiuli Department of Photomedicine, Shanghai Skin Disease Hospital, 200443, China Biophotonics Research Laboratory, Center for Interdisciplinary Biomedical Education and Research, University Central Oklahoma, Edmond, OK 73034, USA These authors have contributed equally to this work Correspondence to: Wang, e-mail: xlwang2001@aliyun.com Chen, wchen@uco.edu Keywords: dendritic...
Non-small cell lung cancer (NSCLC) is a common malignant tumor, with high morbidity and mortality. Circular RNA (circRNA) circ_0003028 was reported to be upregulated in NSCLC. This study designed explore the role mechanism of on NSCLC progression. In this work, circ_0003028, microRNA-1298-5p (miR-1298-5p), glutamic oxaloacetic transaminase 2 (GOT2) level were detected by real-time quantitative polymerase chain reaction (RT-qPCR). The localization analyzed subcellular fractionation assay....
Excessive application of nitrogen fertilizers has inevitably resulted in environmental problems. The symbiotic fixation (SNF) that occurs the root nodules leguminous plants provides a sustainable source reduced agricultural ecosystems. More than 200 genes have been reported to regulate SNF, including rhizobial infection, nodule organogenesis and senescence (Roy et al., 2020). Mature consist mainly two cell types: infected cells (IC) contain nitrogen-fixing bacteroids uninfected (UC) mediate...
Abstract Background Breast cancer (BC) is one of the most prevalent malignant tumours that threatens women health worldwide. It has been reported circular RNAs (circRNAs) play an important role in regulating tumour progression and microenvironment (TME) remodelling. Methods Differentially expression characteristics immune correlations circRNAs BC were verified using high‐throughput sequencing bioinformatic analysis. Exosomes characterised by nanoparticle transmission electron microscopy...
Intrinsically disordered proteins (IDPs), characterized by a lack of defined tertiary structure, are ubiquitous and indispensable components cellular machinery. These participate in diverse array biological processes, often undergoing conformational transitions upon binding to their target, phenomenon termed "folding-upon-binding." The finding raises the question how achieve rapid kinetics presence intrinsic disorder, underlying molecular mechanism remains elusive. This study investigated...
Dendritic cell (DC) vaccines were generated by apoptotic squamous carcinoma (SCC) cells induced 5-aminolevulinic acid (ALA)-mediated photodynamic therapy (PDT). ALA-PDT-DC vaccine inhibited the growth of SCC in mice, indicating that immunogenic can activate an effective antitumor adaptive immunity and lead to a DC vaccine-based cancer immunotherapy.
// Qiang Li 1, * , Xuefeng Xia Jie Ji 2 Jianghui Ma 1 Liang Tao Linjun Mo 3 Wei Chen 4 Department of General Surgery, The Afflicted Drum Tower Hospital Nanjing University Medical School, Nanjing, China Nangjing University, Nangjing, School Western Australia, and Australia Liver Kidney Surgical Transplant Service, Sir Charles Gairdner Hospital, Perth, Institute Molecular Engineering, Chicago, Illinois, USA These authors contributed equally to this work share the first authorship...
Periconceptional folic acid (FA) supplementation is recommended to prevent neural tube defects and other birth defects. After 20 years mandate food fortification with FA, serum concentration of folate unmetabolized FA increased significantly in the North American population. But whether excess intake impairs neurodevelopment behavior still controversial. Here, we treated mice approximately 2.5-fold (moderate dose MFA) or 10-fold (high HFA) dietary requirement one week before mating...
Stigma characteristics are important factors affecting the seed yield of hybrid rice per unit area. Natural variation stigma has been reported in rice, but genetic basis for this is largely unknown. We performed a genome-wide association study on three six environments using 1.3 million single-nucleotide polymorphism (SNPs) characterized 353 diverse accessions Oryza sativa. An abundance phenotypic was present these collections. identified four significant SNPs associated with length, 20...