A5100731392- Acute Myeloid Leukemia Research
- Photodynamic Therapy Research Studies
- Chronic Myeloid Leukemia Treatments
- Retinoids in leukemia and cellular processes
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Renal and related cancers
- Eosinophilic Disorders and Syndromes
- Protein Degradation and Inhibitors
- Chronic Lymphocytic Leukemia Research
- Epigenetics and DNA Methylation
- Hematopoietic Stem Cell Transplantation
- Hepatocellular Carcinoma Treatment and Prognosis
- Gastric Cancer Management and Outcomes
- RNA Interference and Gene Delivery
- Immune Cell Function and Interaction
- Lymphoma Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Genomics, phytochemicals, and oxidative stress
- Advanced Photocatalysis Techniques
- RNA Research and Splicing
- Multiple Myeloma Research and Treatments
- MicroRNA in disease regulation
- Acute Lymphoblastic Leukemia research
- melanin and skin pigmentation
- Mesenchymal stem cell research
Second Hospital of Shanxi Medical University
2016-2025
Shanxi Medical University
2016-2025
Shanxi University
2024-2025
Tianjin Medical University Cancer Institute and Hospital
2025
Union Hospital
2025
Jilin University
2025
Wenzhou Medical University
2008-2024
Gansu University of Traditional Chinese Medicine
2017-2024
Chinese PLA General Hospital
2020-2024
Nanjing University
2016-2024
Abstract Gastric cancer is one of the most common malignant tumors, and chemotherapy main treatment for advanced gastric cancer. However, resistance leads to failure poor prognosis in patients with Multidrug (MDR) a major challenge that needs be overcome chemotherapy. According recent research, ferroptosis activation crucial tumor therapeutic strategies. In this work, we explored solution chemoresistance by investigating effects Chinese medicine monomer baicalin on ferroptosis. Baicalin...
A relationship between human papillomavirus (HPV) infection and papillary squamous cell carcinoma (PSCC) has been suggested. However, to date, no studies have thoroughly directly evaluated for transcriptional activity of the virus or clinicopathologic significance HPV-positive PSCC. Forty-eight cases PSCC were retrieved from our surgical pathology database reviewed by 4 study pathologists, with tumors defined as SCC a significant component growth in tumor. Immunohistochemical analysis p16...
// Xiaojie Wang 1, * , Jie Ji Haiyan Zhang 1 Zhixia Fan Linglin Lei Shi Feifan Zhou 2 Wei R. Chen 2, Hongwei 3 Xiuli Shanghai Skin Disease Hospital, 200443, China Biophotonics Research Laboratory, Center for Interdisciplinary Biomedical Education and Research, University of Central Oklahoma, Edmond, OK 73034, USA Huadong Fudan University, 200040, These authors have contributed equally to this work Correspondence to: Wang, e-mail: wangxiuli20150315@163.com hongweiwang2005@aliyun.com Keywords:...
Chromobox protein homolog 7 (CBX7), one of the polycomb group (PcG) proteins, is a transcriptional repressor involved in regulation cell proliferation and senescence. In present study, we showed that CBX7 negatively regulates proliferation, viability, chemoresistance, migration pancreatic cancer cells. Overexpression significantly inhibited cells vitro vivo. Depletion facilitated their growth. also impaired viability chemoresistance Transwell assays reduces migratory capacity Of note,...
Estimated glucose disposal rate (eGDR) is considered as a reliable alternative indicator of insulin resistance. However, the relationship between eGDR levels and mortality among individuals with cardiometabolic syndrome (CMS), well within different metabolic states in this population, remains unclear. We conducted cohort study on 9928 CMS participants from National Health Nutrition Examination Survey (NHANES) database 1999 to 2018. The population was evaluated using multivariable Cox...
To study the expression of SPOP in patients with acute myeloid leukemia (AML) and its effect on proliferation, apoptosis cycle AML cells. RT-qPCR was used to detect mRNA bone marrow samples newly diagnosed normal controls. The stable overexpression cell lines THP-1 U937 were constructed by liposome transfection. proliferation detected CCK-8, flow cytometry. expressions anti-apoptotic protein Bcl-2 apoptotic Bax, Caspase3 Western blot. median level control group 0.993 1(0.6303, 1.433), while...
Background: Squamous cell carcinoma (SCC) is a common skin cancer, and its treatment still difficult. The aim of this study was to evaluate the effectiveness nanoparticle (NP)-assisted 5-aminolevulinic acid (ALA) delivery for topical photodynamic therapy (PDT) cutaneous SCC. Materials methods: Ultraviolet-induced SCCs were established in hairless mice. ALA-loaded polylactic-co-glycolic (PLGA) NPs prepared characterized. kinetics ALA PLGA NP-induced protoporphyrin IX fluorescence SCCs,...
Speckle-type POZ protein (SPOP) is an adaptor of the cullin 3-based ubiquitin ligase responsible for degradation oncoproteins frequently overexpressed in many tumor cells.Altered expression and somatic mutations SPOP have been observed various types with chromosomal aberrations, indicating a role maintaining genome stability, although detailed mechanism remains unclear.Here, we show that component DNA damage response (DDR).SPOP recruited to doublestrand break sites it forms nuclear foci...
Osteosarcoma is the most frequent malignant bone tumor, affecting extremities of adolescents and young adults. Ubiquitin-specific protease 1 (USP1) plays a critical role in many cellular processes including proteasome degradation, chromatin remodeling cell cycle regulation. In present study, we discovered that USP1 was overexpressed 26 out 30 osteosarcoma tissues compared to cartilage tumor normal tissues. We then constructed lentiviral vector mediating RNA interference (RNAi) targeting...
Background: Topical photodynamic therapy (PDT) mediated with 5-aminolevulinic acid (ALA) offers an alternative option for the treatment of acne vulgaris. Objective: To study effects ALA dose, incubation time, and lesion type on protoporphyrin IX (PpIX) production outcomes. Methods: examine time course PpIX production, 10% was applied to inflammatory papules 1 5 hours followed by in situ fluorescence examination. determine dose type, 3, 5, lesions split-face fashion 3 whole-face light...
Abstract Various methods have been used to reconstruct the penis. The objective of this study was investigate feasibility constructing engineered corpus cavernosum with primary mesenchymal stem cells (MSCs) in a rabbit model vitro . Acellular corporal matrices (ACMs) were obtained from adult penile tissues through an established decellularization procedure. MSCs separated, purified, and then seeded on ACMs construct cavernosum. subsequently cultured incubator for 14 days. Histological...
Abstract Objective This study intended to establish a droplet digital PCR (dd‐ ) for monitoring minimal residual disease ( MRD in patients with BCR / ABL (P210)‐positive chronic myeloid leukemia CML ), thereby achieving deep‐level of tumor load and determining the efficacy guided clinically individualized treatment. Methods Using dd‐ RT ‐ qPCR , two cell suspensions were obtained from K562 cells normal peripheral blood mononuclear by gradient dilution measured at cellular level. At PB level,...