A5035523819- Sexual function and dysfunction studies
- Renal and related cancers
- Hormonal and reproductive studies
- Urinary Bladder and Prostate Research
- Sexuality, Behavior, and Technology
- Hippo pathway signaling and YAP/TAZ
- Genetic and Kidney Cyst Diseases
- Pluripotent Stem Cells Research
- Urological Disorders and Treatments
- Caveolin-1 and cellular processes
- Hedgehog Signaling Pathway Studies
- Epigenetics and DNA Methylation
- COVID-19 Clinical Research Studies
- RNA Research and Splicing
- COVID-19 Impact on Reproduction
- Tissue Engineering and Regenerative Medicine
- Chronic Kidney Disease and Diabetes
- Sperm and Testicular Function
- Acute Kidney Injury Research
- CRISPR and Genetic Engineering
- Plant Toxicity and Pharmacological Properties
- Connexins and lens biology
- Phagocytosis and Immune Regulation
- Diabetes and associated disorders
- Menstrual Health and Disorders
Binzhou University
2020-2025
Qilu Hospital of Shandong University
2024-2025
Binzhou Medical University
2020-2025
Shandong Provincial Hospital
2019-2024
Shandong University
2016-2024
Shandong First Medical University
2020-2024
Shandong University of Traditional Chinese Medicine
2018-2024
Second Hospital of Shandong University
2015-2023
Affiliated Hospital of Shandong University of Traditional Chinese Medicine
2017-2021
Abstract Background Since SARS‐CoV‐2 infection was first identified in December 2019, the novel coronavirus‐induced pneumonia COVID‐19 spread rapidly and triggered a global pandemic. Recent bioinformatics evidence suggested that angiotensin‐converting enzyme 2—the main cell entry target of SARS‐CoV‐2—was predominantly enriched spermatogonia, Leydig Sertoli cells, which suggests potential vulnerability male reproductive system to infection. Objectives To identify RNA seminal plasma determine...
Although mature podocytes lack tight junctions, junction integral membrane protein claudin-5 (CLDN5) is predominantly expressed on plasma membranes of under normal conditions. Using podocyte-specific Cldn5 knockout mice, we identify CLDN5 as a crucial regulator podocyte function and reveal that deletion exacerbates injury proteinuria in diabetic nephropathy mouse model. Mechanistically, reduces ZO1 expression induces nuclear translocation ZONAB, followed by transcriptional downregulation WNT...
Introduction The low-density lipoprotein receptor (LDLR) is integral to cholesterol metabolism and cardiovascular health. Enhancing LDLR expression a promising strategy for treating hyperlipidemia reducing the risk of atherosclerosis. However, current reporter systems have limitations in detecting both transcriptional translational regulation. To address this, we developed novel dual-reporter system incorporating Enhanced Green Fluorescent Protein (EGFP) Gaussia luciferase (Gluc) enable...
Acute kidney injury (AKI) is a frequent clinical complication in critically ill patients, and it rapidly develops into renal failure with high morbidity mortality. However, other than dialysis, no effective therapeutic interventions can offer reliable treatment to limit improve survival. Here, we firstly reported that remdesivir (RDV, GS-5734), broad-spectrum antiviral nucleotide prodrug, alleviated AKI by specifically inhibiting NOD-, LRR-, pyrin domain-containing protein 3 (NLRP3)...
Abstract Various methods have been used to reconstruct the penis. The objective of this study was investigate feasibility constructing engineered corpus cavernosum with primary mesenchymal stem cells (MSCs) in a rabbit model vitro . Acellular corporal matrices (ACMs) were obtained from adult penile tissues through an established decellularization procedure. MSCs separated, purified, and then seeded on ACMs construct cavernosum. subsequently cultured incubator for 14 days. Histological...
Erectile dysfunction (ED) is a common complication of pelvic fractures. To identify the vascular and neurogenic factors associated with ED, 120 patients admitted ED after traumatic fracture between January 2009 June 2013 were enrolled in this study. All answered International Index Function (IIEF-5) questionnaire. Nocturnal penile tumescence (NPT) testing confirmed occurrence 96 (80%) on whom duplex ultrasound neurophysiological further performed. Of these 29 (30%) demonstrated only...
Abstract Background Intracavernous injection of mesenchymal stem cells (MSCs) is a promising method for diabetic mellitus-induced erectile dysfunction (DMED), but short survival time MSCs in cavernous fatal defect therapy. This study investigated therapeutic efficiency and potential mechanism probucol combined with MSCs. Methods In vivo study, total forty-eight 10-week-old male Sprague-Dawley (SD) rats were used. Twelve received intraperitoneal PBS as the sham group; rest 60 mg/kg...
Abstract Hypoxia-inducible factor-1α (HIF-1α) has been implicated in the transcriptional regulation of telomerase reverse transcriptase (hTERT) gene expression and activity, essential elements for cellular immortalization transformation. However, controversial results were obtained different studies. Moreover, it is totally unclear whether HIF-2α, paralog HIF-1α, plays a role regulating hTERT expression. In present study, we found that hypoxic treatment enhanced mRNA activity three renal...
Lipolysis-stimulated lipoprotein receptor (LSR) is a multi-functional protein that best known for its roles in assembly of epithelial tricellular tight junctions and hepatic clearance lipoproteins. Here, we investigated whether LSR contributes to intestinal epithelium homeostasis pathogenesis disease. By using multiple conditional deletion mouse models ex vivo cultured organoids, find elimination stem cells results the disappearance Paneth without affecting differentiation other cell...
Mean platelet volume (MPV) and Platelet distribution width (PDW) are potential markers in activation. In present study, we aimed to evaluate MPV PDW as severity for those patients who complaining erectile dysfunction (ED). A total of 358 participants were enrolled this study. The whole cohort was asked complete the International Index Erectile Function-5 (IIEF-5) questionnaire. classified into 3 groups: control group (n = 120), mild ED 118) severe 120). We found our significantly higher both...
Although elevated prolactin levels have been shown to inhibit penile erection, the relationship between and erection of tip or base has not extensively researched. We therefore investigated prolactin's effects on base, with a cross-sectional study 135 patients erectile dysfunction, based scores ≤21 International Index Erectile Function-5. All were tested for nocturnal tumescence, blood pressure, serum glucose, total cholesterol, triglyceride, high-density lipoprotein, low-density luteinizing...
Background: Since SARS-CoV-2 infection was first identified in December 2019, the novel coronavirus induced pneumonia spread rapidly and triggered a global pandemic. Recent bioinformatics evidence reported that angiotensin converting enzyme 2 (ACE2) predominantly enriched spermatogonia, leydig Sertoli cells, suggesting potential risk of male reproductive system to be vulnerable attack. Methods: From February 26 April 2, 2020, 23 COVID-19 patients were recruited this study. The clinical...
Background: Bladder cancer (BLCA) is the major tumor of urinary system, and immune-related genes (IRGs) contribute significantly to its initiation prognosis. Results: A total 51 prognostic IRGs associated with overall survival were identified. Functional enrichment analysis revealed that these actively involved in tumor-related functions pathways. Using multivariate Cox regression analysis, we detected 11 optimal (ADIPOQ, PPY, NAMPT, TAP1, AHNAK, OLR1, PDGFRA, IL34, MMP9, RAC3, SH3BP2). We...
Urothelial cells have been implicated in bladder mechanosensory transduction, and thus, initiation of the micturition reflex. Cell deformation caused by tension forces at an air-liquid interface (ALI) can induce increase intracellular Ca 2+ concentration ([Ca ] i ) ATP release some epithelial cells. In this study, we aimed to examine cellular mechanisms underlying ALI-induced [Ca cultured urothelial The ALI was created stopping influx perfusion but maintaining efflux. measured using imaging...
Past studies have shown that elevated estradiol levels could inhibit penile erection, but the relationship between and erection of tip or base has not been extensively researched.We therefore investigated estradiol's effects on base, with a cross-sectional study 135 patients erectile dysfunction (ED), based scores ≤21 according to International Index Erectile Function-5. All were tested for nocturnal tumescence, blood pressure (BP), serum glucose, total cholesterol (TC), triglyceride (TG),...
Verbascoside (VB), which is found in many medicinal plant families, exhibits biological activities various diseases. However, its effects on varicocele (VCL)-induced damage remain unknown.To investigate the and mechanism of VB experimental rats with damage.Sixty sexually mature male Sprague-Dawley (SD) were divided into six groups (n = 10): control, control-sham, VCL-vehicle (normal saline), VCL + (50, 100, 200 mg/kg/day, intraperitoneally). After 4 weeks treatment, all animals sacrificed,...
Here, we report a 41-year-old female with type II VUF after hysteromyomectomy.We the diagnosis of by imaging method, and provide feasible treatment for this complication pelvic surgery.
FRAS1 (Fraser syndrome protein 1), together with FREM1 (the Fras1-related extracellular matrix proteins 1) and FREM2, belonging to the FRAS1/FREM family, are considered play essential roles in renal organogenesis cancer progression. However, their kidney clear cell carcinoma (KIRC) remain be elucidated.
Penile hypersensitivity is one of the main pathological mechanisms premature ejaculation. However, little known about neurophysiological mechanism penile peripheral nerve sensitization. Piezo Type Mechanosensitive Ion Channel Component 2 (PIEZO2), was recently identified as a mechanically sensitive channel.This study explored possible neural PIEZO2 action in ejaculation using molecular biology and electrophysiology approaches.One hundred seventy male rats 85 female were recruited. The...
Human pluripotent stem cell (hPSC)-derived kidney organoids may contribute to disease modeling and the generation of replacement tissues. However, realization such applications requires induction hPSCs into functional mature organoids. One key questions for this process is whether a specific vascular system exists nephrogenesis. Our previous study showed that short-term (2 weeks) implantation hPSC-derived below capsules unilaterally nephrectomized immunodeficient mice resulted in enlargement...
Background Embryonic metanephros is the mammalian renal anlagen, which considered as a potential source for regeneration of functional whole kidneys. Some studies reported that implanted into unilateral nephrectomized animals can develop kidney tissue. However, kidneys are nephrotoxic in failure patients, and whether grow has not been reported. This study aims to investigate growth acute environment analyze therapeutic effect microenvironment on injury (AKI).Methods AKI was induced 200 g...