A5100752270- Epigenetics and DNA Methylation
- Bladder and Urothelial Cancer Treatments
- Renal and related cancers
- Telomeres, Telomerase, and Senescence
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Cancer-related gene regulation
- Cancer, Hypoxia, and Metabolism
- Cardiovascular and exercise physiology
- Ferroptosis and cancer prognosis
- Body Composition Measurement Techniques
- Gastrointestinal disorders and treatments
- Urinary and Genital Oncology Studies
- Psychosomatic Disorders and Their Treatments
- Breast Lesions and Carcinomas
- Education and Vocational Training
- Autoimmune Bullous Skin Diseases
- IgG4-Related and Inflammatory Diseases
- Artificial Intelligence in Healthcare
- Traditional Chinese Medicine Studies
- Organ and Tissue Transplantation Research
- Head and Neck Cancer Studies
- Dialysis and Renal Disease Management
- Bone Metabolism and Diseases
China Medical University
2024
Linyi University
2022-2024
Qingdao University
2023
Affiliated Hospital of Qingdao University
2023
South China Normal University
2022
Peking Union Medical College Hospital
2018-2020
Chinese Academy of Medical Sciences & Peking Union Medical College
2018-2020
Capital Medical University
2020
Zhejiang Chinese Medical University
2018
Nanjing Normal University
2018
// Kun Wang 1, 2, * , Tiantian Liu 3, Nan Ge 4, Li 5 Xiaotian Yuan 2 Jikai 1 Feng Kong 4 Chang Hongbo Ren Keqiang Yan Sanyuan Hu 6 Zhonghua Xu Magnus Björkholm Yidong Fan Shengtian Zhao Cheng Dawei Department of Urology, Shandong University Qilu Hospital, Jinan, China Medicine, Division Hematology and Centre for Molecular Karolinska Hospital Solna Institutet, Stockholm, Sweden 3 Pathology, School Urology Central Research Laboratory, Second Nursing, General Surgery, These authors...
Oct4 and Sox2 are two major transcription factors related to the stem cell self-renewal differentiation. The aim of this study was examine association between expression levels with both clinicopathological characteristics prognoses patients hypopharyngeal squamous carcinoma.Tumor tissue samples from 85 carcinoma were collected, clinical follow-up data these recorded, status examined in by immunohistochemistry (IHC).Oct4 found be an independent predictive factor for overall survival (p =...
TERT promoter mutations are identified in many malignancies including bladder cancer (BC) and upper tract urothelial carcinoma (UTUC). In contrast, no were found renal cell (RCC) as reported a recent study. Because the mutant urine DNA was recently tested marker for BC, it is important to ascertain whether these truly absent RCCs. Here we determined 109 patients with RCC 14 UTUC. The 9/96 (9.3%) clear (ccRCC) tumors 1/8 (13%) chromophobe tumors. Among ccRCC patients, mutation correlated...
Abstract Activation of telomerase, a key event during immortalization and malignant transformation, requires expression the telomerase reverse transcriptase (hTERT). Consistently, lack activity hTERT occurs in most normal human somatic cells. However, it has been observed that both cancerous renal tissues express whereas only latter exhibits activity. The mechanism underlying dissociation between is unclear. In present study, we examined alternative splicing transcripts cell carcinoma (RCC)...
The significance of SOX2 in nasopharyngeal carcinoma (NPC), a tumor associated with Epstein–Barr virus (EBV), remains unclear. Here, we reported that, the univariate analysis, expression was correlated poorer distant metastasis-free survival (DMFS). EBV-VCA/IgA titers patients NPC were also overall (OS). Patients NPC, who had both strong staining and high EBV-VCA/IgA, poorest prognoses. Therefore, or combination level could be valuable to predict metastasis prognosis NPC.
Abstract The TERT promoter and FGFR3 gene mutations are two of the most common genetic events in urothelial bladder cancer (UBC), these mutation assays patient urine have been shown to be promising biomarkers for UBC diagnosis surveillance. These results were obtained mainly from studies patients with Western countries, little is known about such information Han Chinese UBC. In present study, we addressed this issue by analyzing tumors 182 samples 102 mRNA expression and/or urine. identified...
Abstract Hypoxia-inducible factor-1α (HIF-1α) has been implicated in the transcriptional regulation of telomerase reverse transcriptase (hTERT) gene expression and activity, essential elements for cellular immortalization transformation. However, controversial results were obtained different studies. Moreover, it is totally unclear whether HIF-2α, paralog HIF-1α, plays a role regulating hTERT expression. In present study, we found that hypoxic treatment enhanced mRNA activity three renal...
Abstract Background This study was designed to determine the pattern and correlation between expression of HIF-1α transcriptional targets TGM2 BNIP3 in laryngeal cancer, investigate association with clinical outcome squamous cell carcinoma (SCC) patients receiving postoperative radiotherapy. Methods Immunostaining antibodies specific performed formalin-fixed, paraffin-embedded specimens from 148 SCC patients. scored as high or low, based on number tumor cells stained staining intensity. All...
Transcutaneous electrical acupoint stimulation (TEAS) has the potential to alleviate post-traumatic stress disorder (PTSD). The purpose of this study was determine whether adding TEAS sertraline or cognitive behavioral therapy (CBT) could improve anti-PTSD efficacy.In randomized controlled trial, 240 PTSD patients (60 in each group) were assigned receive simulated combined with (group A) CBT B), active C), plus D) for 12 weeks. outcomes measured using Clinician-Administered Scale, Check...
Urothelial cell carcinoma (UCC) includes urothelial bladder (UBC), renal pelvic (RPC) and ureter (UC), its incidence varies dependent on geographical areas tumor locations, which indicates different oncogenic mechanisms and/or genetic susceptibility/environment exposure. The activating mutations of the fibroblast growth factor receptor 3 (FGFR3) gene telomerase reverse transcriptase (TERT) promoter are most frequent events in UCCs. These have clinical utilities UCC initial diagnostics,...
Pancreatic ductal adenocarcinoma (PDAC) has the highest mortality rate among all solid tumors. Tumorigenesis is promoted by oncogene KRAS, and KRAS mutations are prevalent in patients with PDAC. Therefore, a comprehensive understanding of interactions between PDAC may expediate development therapeutic strategies for reversing progression malignant Our study aims at establishing validating prediction model based on survival analysis mRNA expression.
Here we investigated the regulation of Th17 and Treg cells in orthodontic tooth movement during periodontal inflammation.Fifty-six SD rats were divided into a control (24 rats) group recovery stage periodontitis (RM group, 32 rats). Periodontitis was established by silk ligation local injection LPS. Orthodontic achieved nickel-titanium springs on maxillary first molars. The proportions evaluated flow cytometry. Gene expression ROR-γt Foxp3 determined real-time PCR. Expression ROR-γt, Foxp3,...
Although malignancy and chronic inflammatory diseases seem to be associated with one another, gastric carcinoma (GC) systemic lupus erythematosus (SLE) remains a very rare association. A 63-year-old man presented 4-month history of unintentional decreased appetite, weight loss, fatigue, but no fever, abdominal pain, or other discomfort symptoms. Endoscopic examination revealed an irregular 5-cm mucosal lesion on the flexure. The pathology poorly differentiated adenocarcinoma (mainly signet...
ObjectiveThe deoxyribonucleic acid-repair protein O6-methylguanine-deoxyribonucleic acid methyltransferase is a major determinant of resistance cells to various alkylating drugs. Its expression profile different in cancer types. Here, we studied the and function clear cell renal carcinoma.
This work aims to comprehensively explore the influencing factors of aerobics athletes' performance by integrating sports nutrition assistance and artificial intelligence neural networks. First, a personalized assessment analysis nutritional needs are conducted, collecting various data including fitness tests, physiological monitoring, surveys establish model for athletes. In order gain more comprehensive understanding characteristics requirements aerobic athletes, exercise integrated with...
With the progress of society and improvement living standards, sports training has gradually become an area increasing concern for individuals. To more comprehensively grasp physical function, body shape, fitness athletes, many researchers have conducted extensive research on real-time detection human nutrition. This study is mainly supported by cloud computing somatosensory network technology, composition in main object. In experiment, two methods were tested: BIA method analysis based...
Background: Small gastrointestinal stromal tumors (GISTs) are defined as less than 2 cm in diameter, which often found incidentally during gastroscopy. There is controversy regarding the management of small GISTs and a certain percentage become malignant follow-up. Previous studies have shown that mutation rate significantly lower large used Sanger targeted sequencing. The aim this study was to investigate overall mutational profile GISTs, including those wild-type tumors, using whole exome...
Objective To examine the relationship between HIF-1αt and VEGF expression clinicopathological characteristics in hypopharyngeal squamous cell carcinoma. Methods The status of HIF-1α were examined by immunohistochemistric method (IHC) 62 tumor tissue 19 paracancerous normal tissue. relationships characteristic analyzed. Results higher carcinoma tissues than those (66. 1％:26. 3％ ;x2 =18. 02,P ＜0. 05 ;67. 7％ : 31.6％ ; x2 =19.22, P ＜ 0. ). intensity HIF-1 α was related to T stage, N stage TNM (...
The Education Informatization 2.0 Action Plan is a concrete implementation plan for advancing Chinese "Internet + Education". It an inevitable choice adapting to the development of education using intelligent environment, and it also effective way speed up realization modernization. Against this background, necessary constantly perfect improve vocational resources help promote personnel by sorting out status quo resources. This article reports use CiteSpace4.0.R5 analyze current literature...
患者女，60岁。因"胸闷、喘憋20 d"于2019年1月23日入住北京协和医院老年医学科。患者自2014年发现左乳肿物，多次手术后复发，病理提示乳腺恶性分叶肿瘤，本次起病因肿瘤复发并合并心脏、肺脏转移，合并慢性弥漫性血管内凝血。经心腔内肿瘤切除术、肺部病灶介入下微波消融术后症状缓解，凝血功能、血小板计数有所恢复。本例患者为全世界第4例乳腺恶性分叶肿瘤心腔内转移，首例同时发现心脏、肺脏转移。.