A5101586072- Bladder and Urothelial Cancer Treatments
- Cancer, Lipids, and Metabolism
- Renal cell carcinoma treatment
- Urinary and Genital Oncology Studies
- Ferroptosis and cancer prognosis
- Cholesterol and Lipid Metabolism
- Epigenetics and DNA Methylation
- Prostate Cancer Treatment and Research
- Testicular diseases and treatments
- Bone health and treatments
- Cancer Immunotherapy and Biomarkers
- Renal and related cancers
- Pediatric Urology and Nephrology Studies
- Muscle and Compartmental Disorders
- Peroxisome Proliferator-Activated Receptors
- Sphingolipid Metabolism and Signaling
- Cardiovascular Effects of Exercise
- Smoking Behavior and Cessation
- Pneumonia and Respiratory Infections
- Natural product bioactivities and synthesis
- Ubiquitin and proteasome pathways
- Blood groups and transfusion
- Immune Cell Function and Interaction
- Inflammatory Biomarkers in Disease Prognosis
- Aortic Disease and Treatment Approaches
Qilu Hospital of Shandong University
2013-2025
Zhengzhou University
2023-2024
China National Center for Food Safety Risk Assessment
2018
Karolinska Institutet
2017
Jinshan Hospital of Fudan University
2016
Shandong University
2014-2015
Chinese Academy of Medical Sciences & Peking Union Medical College
2012-2014
// Kun Wang 1, 2, * , Tiantian Liu 3, Nan Ge 4, Li 5 Xiaotian Yuan 2 Jikai 1 Feng Kong 4 Chang Hongbo Ren Keqiang Yan Sanyuan Hu 6 Zhonghua Xu Magnus Björkholm Yidong Fan Shengtian Zhao Cheng Dawei Department of Urology, Shandong University Qilu Hospital, Jinan, China Medicine, Division Hematology and Centre for Molecular Karolinska Hospital Solna Institutet, Stockholm, Sweden 3 Pathology, School Urology Central Research Laboratory, Second Nursing, General Surgery, These authors...
TERT promoter mutations are identified in many malignancies including bladder cancer (BC) and upper tract urothelial carcinoma (UTUC). In contrast, no were found renal cell (RCC) as reported a recent study. Because the mutant urine DNA was recently tested marker for BC, it is important to ascertain whether these truly absent RCCs. Here we determined 109 patients with RCC 14 UTUC. The 9/96 (9.3%) clear (ccRCC) tumors 1/8 (13%) chromophobe tumors. Among ccRCC patients, mutation correlated...
ABCA1 and scavenger receptor class B type I (SR-BI)/CD36 lysosomal integral membrane protein II analogous 1 (CLA-1) are the key transporter in reverse cholesterol transport (RCT). Increasing expression level of SR-BI/CLA-1 is antiatherogenic. The aim study was to find novel antiatherosclerotic agents upregulating from natural compounds. Using ABCA1p-LUC CLA-1p-LUC HepG2 cell lines, we found that rutaecarpine (RUT) triggered promoters CLA-1 genes. RUT increased vitro related liver X alpha...
Abstract Deregulation of microRNAs (miRNAs) contributes to the development and progression many cancer types; however, their functions in pathogenesis testicular germ cell tumor (TGCT) remain unclear. Here, we determined miRNA expression profiles TGCTs normal testes using small RNA sequencing, identified several deregulated miRNAs TGCTs, including miR-506~514 cluster. In functional studies vitro demonstrated that miR-514a-3p induced apoptosis through direct regulation paternally expressed...
Background Clear cell renal carcinoma is the most predominant type of malignancies, characterized by high aggressiveness and probability distant metastasis. Renin angiotensin system (RAS) plays a crucial role in maintaining fluid balance within human body, its involvement tumorigenesis increasingly being uncovered, while ccRCC remains unclear. Methods WGCNA was used to identify RAS related genes. Machine learning applied screen hub genes for constructing risk model, E-MTAB-1980 dataset...
Abstract Receptor tyrosine kinase (RTK) inhibitors, such as sunitinib and sorafenib, remain the first-line drugs for treatment of mRCC. Acquired drug resistance metastasis are main causes failure. However, in case Renal Cell Cancer (mRCC), which showed a good response to sunitinib, we found that long-term with could promote lysosome biosynthesis exocytosis, thereby triggering RCC. By constructing sunitinib-resistant cell lines vivo, confirmed TFE3 plays key role acquired Under stimulation...
Abstract The TERT promoter and FGFR3 gene mutations are two of the most common genetic events in urothelial bladder cancer (UBC), these mutation assays patient urine have been shown to be promising biomarkers for UBC diagnosis surveillance. These results were obtained mainly from studies patients with Western countries, little is known about such information Han Chinese UBC. In present study, we addressed this issue by analyzing tumors 182 samples 102 mRNA expression and/or urine. identified...
The androgen receptor (AR) plays a pivotal role in prostatic carcinogenesis, and it also affects the transition from hormone sensitive prostate cancer (HSPC) to castration-resistant (CRPC). Particularly, persistent activation of appearance splicing variant 7 (AR-V7), could partly explain failure deprivation therapy (ADT). In present study, we reported that huaier extract, derived officinal fungi, has potent antiproliferative effects both HSPC CRPC cells. Mechanistically, extract...
BackgroundThe presence of peripheral inflammatory cells has been linked to the prognosis cancer. This study aims investigate distinct roles absolute neutrophil count (ANC) and monocyte (AMC) in differentiating renal cell carcinoma (RCC) from angiomyolipoma (RAML), as well their prognostic significance RCC.MethodsWe conducted a comprehensive analysis immune data, clinicopathological tumor characteristics patients diagnosed with RCC or RAML January 2015 December 2021. Receiver operating...
The aim of this study was to improve understanding the clinical, pathologic, and prognostic features urachal carcinoma (UrC), a retrospectively descriptive done in 2 clinical centers.After excluding missed patients, pathological data 59 patients with UrC, who were diagnosed or treated at centers between 1986 2019, analyzed. SPSS 22.0 (IBM) GraphPad Prism 8.0.1 used for statistics visualization. Survival analyzed by Kaplan-Meier method Log-rank tests. Cox proportional hazards regression...
Urokinase is involved in the processes of initiating urinary stones. Several published case-control studies have examined relationship urokinase gene 3'-untranslated region (3'-UTR) T/C polymorphism and urolithiasis, but yielded inconsistent findings. In this study, a comprehensive meta-analysis was conducted by pooling relevant to obtain reliable conclusions. Studies focusing on association between 3'-UTR urolithiasis were retrieved through PubMed, Medline, Web Science China National...
It is known that the ATP-binding cassette transporter A1 (ABCA1) plays a major role in cholesterol homeostasis and high density lipoprotein (HDL) metabolism. Several laboratories have demonstrated ABCA1 binding to lipid-poor apolipoprotein A-I (apoA-I) will mediate assembly of nascent HDL cellular efflux, which suggests possible receptor-ligand interaction between apoA-I. In this study, cell-based-ELISA-like high-throughput screening (HTS) method was developed identify synthetic natural...
Background Establishment of sister chromatid cohesion N-acetyltransferase 2 (ESCO2), a member the EFO2 family, is implicated in pathogenesis and progression various cancers. However, there has been limited comprehensive pan-cancer analysis conducted on ESCO2 thus far. Methods Publicly available databases, such as UCSC Xena database, were utilized to examine differential expression patterns across cancer types. In addition, variations levels investigated distinct clinical stages. Univariate...
Objectives This study aimed to evaluate the stiffness of 2‐dimensional (2D) shear wave elastography (SWE) in preoperatively predicting prognostic stage groups invasive ductal carcinoma (IDC). Methods Eighty‐six newly diagnosed lesions on 83 patients with IDCs were analyzed. All parameters from conventional ultrasound and virtual touch tissue imaging quantification collected, mean velocity (SWVmean) was calculated. Data maximum diameter, estrogen receptor (ER), progesterone (PR), human...
Clinically, for testicular tumor patients with negative markers, how to distinguish the malignant from benign is a difficult problem. This study aimed assess clinical significance of absolute monocyte count (AMC) in differential diagnosis germ cell stage S0 (TGCTS0) and tumor. In this retrospective single-center study, total 90 newly diagnosed or TGCTS0 were reviewed. All received surgical intervention as primary treatment method. AMC other clinicopathological parameters analyzed. Receiver...
Purpose: Immune checkpoint therapy (ICT) provides a new idea for the treatment of advanced clear cell renal carcinoma (ccRCC), which can bring significant benefits to patients. However, clinical application ICT is limited because lack predictive biomarkers select potential responders. This study aims propose biomarker predict response Nivolumab in patients with ccRCC. Materials and methods: The genes that significantly improve prognosis ccRCC were retrieved from Cancer Genome Atlas (TCGA)...