A5012617536- Ion Transport and Channel Regulation
- Sphingolipid Metabolism and Signaling
- Peptidase Inhibition and Analysis
- Cancer, Hypoxia, and Metabolism
- Tryptophan and brain disorders
- Quinazolinone synthesis and applications
- Ubiquitin and proteasome pathways
- Histone Deacetylase Inhibitors Research
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- PARP inhibition in cancer therapy
- Cancer Immunotherapy and Biomarkers
- Reproductive Biology and Fertility
- Bioactive Compounds and Antitumor Agents
- Cancer therapeutics and mechanisms
- Computational Drug Discovery Methods
- Natural Compounds in Disease Treatment
- Synthesis and Biological Evaluation
- Endoplasmic Reticulum Stress and Disease
- Cancer Research and Treatments
- Caveolin-1 and cellular processes
- Liver Disease Diagnosis and Treatment
- Cholesterol and Lipid Metabolism
- Synthesis and biological activity
- DNA Repair Mechanisms
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
Academia Sinica
2022-2023
Academy of Medical Sciences
2014-2023
First Affiliated Hospital of Xiamen University
2021-2022
Peking Union Medical College Hospital
2014-2021
Wuhan University
2020-2021
Renmin Hospital of Wuhan University
2020-2021
University of Toledo
2011-2021
Boston IVF
2021
Icahn School of Medicine at Mount Sinai
2019
Ninety-six individuals with Down syndrome over age 35 years were evaluated and followed up for evidence of nontreatable dementia. Dementia was judged to be present when a functional decline occurred in areas such as orientation, memory, verbal motor skills, self-care abilities. Forty-nine patients fit this criterion, an average onset dementia at 54.2 +/- 6.1 years. The prevalence the institutionalized population our study (n = 53) 8% (2/25 patients) between 49 years, 55% (11/20 50 59 75%...
Abstract Glioblastoma is an aggressive tumor that associated with distinctive infiltrating microglia/macrophages populations. Previous studies demonstrated chlorogenic acid (5-caffeoylquinic acid, CHA), a phenolic compound low molecular weight, has anti-tumor effect in multiple malignant tumors. In the present study, we focused on macrophage polarization to investigate mechanisms behind anti-glioma response of CHA vitro and vivo . We found treatment increased expression M1 markers induced by...
Nanos is expressed in multipotent cells, stem cells and primordial germ (PGCs) of organisms as diverse jellyfish humans. It functions together with Pumilio to translationally repress targeted mRNAs. Here we show by loss-of-function experiments that Xenopus Nanos1 required preserve PGC fate. Morpholino knockdown maternal resulted a striking decrease PGCs loss from the gonads. Lineage tracing TUNEL staining reveal Nanos1-deficient fail migrate out endoderm. They appear undergo apoptosis rather...
Polypharmacology is a promising paradigm in modern drug discovery. Herein, we have discovered series of novel PI3K and HDAC dual inhibitors which the hydroxamic acid moiety as zinc binding functional group was introduced to quinazoline-based pharmacophore through an appropriate linker. Systematic structure–activity relationship studies resulted lead compounds 23 36 that simultaneously inhibited with nanomolar potencies demonstrated favorable antiproliferative activities. Compounds...
Primordial germ cells (PGCs) in Xenopus are specified through the inheritance of plasm. During gastrulation, PGCs remain totipotent while surrounding vegetal mass become committed to endoderm action localized maternal transcription factor VegT. We find that although contain VegT RNA, they do not express its downstream targets at mid-blastula transition (MBT). Transcriptional repression correlates with failure phosphorylate serine 2 carboxy-terminal domain (CTD) large subunit RNA polymerase...
ABCA1 and scavenger receptor class B type I (SR-BI)/CD36 lysosomal integral membrane protein II analogous 1 (CLA-1) are the key transporter in reverse cholesterol transport (RCT). Increasing expression level of SR-BI/CLA-1 is antiatherogenic. The aim study was to find novel antiatherosclerotic agents upregulating from natural compounds. Using ABCA1p-LUC CLA-1p-LUC HepG2 cell lines, we found that rutaecarpine (RUT) triggered promoters CLA-1 genes. RUT increased vitro related liver X alpha...
It has not been possible to study the pumping and signaling functions of Na/K-ATPase independently in live cells.Both cell-free cell-based assays indicate that A420P mutation abolishes Src regulatory function Na/K-ATPase.A420P mutant normal but function.Identification regulation-null mutants is crucial for addressing physiological role Na/K-ATPase. The α1 possesses both functions. However, it these cells. We have identified a 20-amino acid peptide (Ser-415 Gln-434) (NaKtide) from nucleotide...
The extracellular heat shock protein 90α (eHSP90α) has been reported to promote cancer cell motility. However, whether pancreatic (PC) cells expressed membrane-bound or secreted HSP90α, as well its underlying mechanism for PC progression, were still unclear. Our study demonstrated that the amounts of HSP90α proteins discrepant in multiple cells. In addition, highly invasive Capan-2 have a higher level compared with those less PL45 conditioned medium recombinant treatment stimulated migration...
Objectives This study aimed to describe the temporal trends in prevalence and disability-adjusted life years (DALYs) of refractive disorders (RD) China globally from 1990 2021 provide predictions for next decade. Methods Utilizing open data Global Burden Disease database (2021), this conducted a comprehensive comparative analysis RD burden globally, including changes DALYs. Joinpoint regression was employed calculate annual percentage change, average its corresponding 95% confidence interval...
Silencing specificity is a critical issue in the therapeutic applications of siRNA, particularly treatment single nucleotide polymorphism (SNP) diseases where discrimination against variation demanded. However, no generally applicable guidelines are available for design such allele-specific siRNAs. In this paper, was approached by using reporter-based assay. With panel 20 siRNAs and 240 variously mismatched target reporters, we first demonstrated that mismatches were discriminated...
The α1 Na/K-ATPase possesses both pumping and signaling functions. Using purified enzyme we found that the might interact with regulate Src activity in a conformation-dependent manner. Here further explored importance of conformational transition capability regulation Src-related signal transduction cell culture. We first rescued α1-knockdown cells by wild-type rat or mutants (I279A F286A) are known to be defective transition. Stable lines comparable expression wild type α1, I279A, F286A...
PD-1 and PD-L1 antibodies have brought about extraordinary clinical benefits for cancer patients, their indications are expanding incessantly. Currently, most PD-1/PD-L1 agents administered intravenously, which may be uncomfortable some patients. Herein, we develop a novel oral-delivered small molecular, YPD-29B, specifically targets human PD-L1. Our data suggested that YPD-29B could potently selectively block the interaction between PD-1, but did not inhibit any other immune checkpoints....
Dihydrofolate reductase (DHFR), a core enzyme of folate metabolism, plays crucial role in the biosynthesis purines and thymidylate for cell proliferation growth both prokaryotic eukaryotic cells. However, development new DHFR inhibitors is challenging due to limited number scaffolds available drug development. Hence, we designed synthesized class with 1,3-diamino-7H-pyrrol[3,2-f]quinazoline derivative (PQD) structure bearing condensed rings. Compound 6r exhibited therapeutic effects on mouse...
Vertebrate axis specification is an evolutionarily conserved developmental process that relies on asymmetric activation of Wnt signaling and subsequent organizer formation the future dorsal side embryo. Although roles during have been studied extensively, it unclear how pathway asymmetrically activated. In Xenopus zebrafish, triggered by determinants, which are translocated from vegetal pole to embryo shortly after fertilization. The transport determinants requires a unique microtubule...
This study aims to examine the cross-sectional association between serum total bilirubin (STB) and type 2 diabetes (T2D) risk in general population, whether obesity could moderate this association.We used data from 1999-2018 National Health Nutrition Examination Surveys (NHANES), including a of 38,641 US adult participants who were 18 years or older. The STB was classified as low, moderate, high groups according tertiles.We found that with lower had significantly higher T2D than those (OR =...
The bacterial ATP-competitive GyrB/ParE subunits of type II topoisomerase are important anti-bacterial targets to treat super drug-resistant infections. Herein we discovered novel pyrrolamide-type inhibitors based on the structural modifications candidate AZD5099 that was withdrawn from clinical trials due safety liabilities such as mitochondrial toxicity. hydroxyisopropyl pyridazine compound 28 had a significant inhibitory effect Gyrase (GyrB, IC50 = 49 nmol/L) and modest Topo IV (ParE,...
A new class of fluorophores 3-alkyl-6-methoxy-7-hydroxy-chromones (AMHCs) is developed and suitable as reagents for biological imaging.
Psoriasis is characterized by abnormal proliferation of keratinocytes, as well infiltration immune cells into the dermis and epidermis, causing itchy, scaly erythematous plaques skin. The understanding this chronic inflammatory skin disease remains unclear all available treatments have their limitations currently. Here, we showed that IMMH002, a novel orally active S1P1 modulator, desensitized peripheral pathogenic lymphocytes to egress signal from secondary lymphoid organs thymus. Using...
Indoleamine 2,3-dioxygenase (IDO) 1 is the key enzyme for regulating tryptophan metabolism and an important target interrupting tumor immune escape. In this study, we designed four series of compounds as potential IDO1 inhibitors by attaching various fragments or ligands to indole phenylimidazole scaffolds improve binding IDO1. The were synthesized their inhibitory activities against evaluated. cytotoxicities two cell lines also determined. Two with a scaffold (DX-03-12 DX-03-13) showed...