A5100457100- Catalytic C–H Functionalization Methods
- Catalytic Cross-Coupling Reactions
- Organoboron and organosilicon chemistry
- Synthesis and biological activity
- Spectroscopy and Laser Applications
- Electrochemical Analysis and Applications
- Catalytic Alkyne Reactions
- Phytochemical compounds biological activities
- Natural product bioactivities and synthesis
- Natural Compounds in Disease Treatment
- Enzyme Catalysis and Immobilization
- Bioactive Compounds and Antitumor Agents
- Metal-Organic Frameworks: Synthesis and Applications
- Particle physics theoretical and experimental studies
- Synthesis and Biological Evaluation
- Covalent Organic Framework Applications
- Radioactive element chemistry and processing
- Advanced Fiber Laser Technologies
- Radical Photochemical Reactions
- Sulfur-Based Synthesis Techniques
- Quantum Chromodynamics and Particle Interactions
- Chemical Synthesis and Analysis
- Carbohydrate Chemistry and Synthesis
- Advanced Nanomaterials in Catalysis
- Phytochemistry and biological activity of medicinal plants
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2025
East China Normal University
2023-2024
Tsinghua University
2018-2024
Henan Agricultural University
2024
Ministry of Agriculture and Rural Affairs
2024
Nanjing Agricultural University
2024
East China University of Science and Technology
2023-2024
Hangzhou Normal University
2024
First Affiliated Hospital Zhejiang University
2024
Jiangsu University
2023-2024
Herein we reported a transition metal-free deborylative cyclization strategy, based on which two routes have been developed, generating racemic and enantioenriched cyclopropylboronates. The of geminal-bis(boronates) bearing leaving group was highly diastereoselective, tolerating few functional groups applicable to heterocycles. When optically active epoxides were used as the starting materials, cyclopropylboronates could be efficiently prepared with >99 % stereospecificity. Mechanistic...
Geminal bis(boronates) are versatile synthetic building blocks in organic chemistry. The fact that they predominantly serve as nucleophiles the previous reports, however, has restrained their potential. Herein we disclose ambiphilic reactivity of α-halogenated geminal bis(boronates), which first catalytic utilization was accomplished by merging a formal Heck cross-coupling with highly diastereoselective allylboration aldehydes or imines, providing new avenue for rapid assembly...
Abstract The site‐selective reaction of a multifunctional linear molecule requires suitable catalyst possessing both uniform narrow channel to limit the rotation and designed active site in channel. Recently, nanoparticles (NPs) were incorporated metal–organic frameworks (MOFs) with tailorable porosity ordered nanochannel, which makes these materials (NPs/MOFs) highly promising candidates as catalytic nanoreactors field heterogeneous catalysis. Inspired by “Gondola” sailing “Venetian Canal”...
Organic isocyanates are versatile intermediates that provide access to a wide range of functionalities. In this work, we have developed the first synthetic method for preparing aliphatic via direct C–H activation. This proceeds efficiently at room temperature and can be applied functionalize secondary, tertiary, benzylic bonds with good yields functional group compatibility. Moreover, isocyanate products readily converted substituted ureas without isolation, demonstrating potential method....
Abstract Compartmentalization is an essential feature found in living cells to ensure multiple biological processes occur without being affected by undesired external influences. Here, compartmentalized systems are developed based on the self‐assembly of metal–organic framework (MOF) nanoparticles into multifunctional MOF capsules (MOF‐Cs). Such MOF‐Cs have capability controlling molecular transportation and protecting interior microenvironment, thus making tandem reaction along trajectories...
Abstract General methods for the preparation of geminal bis(boronates) are great interest due to their widespread applications in organic synthesis. While terminal gem ‐diboron compounds readily accessible, construction sterically encumbered, internal analogues has remained a prominent challenge. Herein, we report formal umpolung strategy access these valuable building blocks. The available 1,1‐diborylalkanes were first converted into corresponding α‐halogenated derivatives, which then serve...
In arid regions conducting flood irrigation, irrigation practice often results in the temporary formation of water ponds cropland, which plays a critical role agricultural productivity. The prompt identification districts is important for effective management water. Utilizing OPtical TRApezoid Model (OPTRAM) soil moisture estimation, we have proposed an improved version OPTRAM aimed to identify district using Sentinel-2 data through Google Earth Engine platform. While wet edge determined...
α-Halogenated boronic esters are versatile building blocks that can be diversified into a wide variety of polyfunctionalized molecules. However, their synthetic potential has been hampered by limited preparation methods. Herein, we report visible light-induced C-H bromination reaction readily available benzyl esters. This method features high yields, mild conditions, simple operation, and good functional group tolerance. The analogous chlorides iodides accessed via Finkelstein reaction....
Compared to chemical methods, the biotransformation of glycyrrhizin (GL) into glycyrrhetinic acid 3- O -mono- β - d -glucuronide (GAMG), which has a higher sweetness and stronger pharmacological activity than those GL, via catalysis by -glucuronidase is an environmentally friendly approach due mild reaction conditions high yield GAMG. However, currently available GUSs show low substrate specificity toward GL further hydrolyze GAMG (GA) as by-product, increasing difficulty subsequent...
The regulation of epigenetic factors is considered a crucial target for solving complex chronic diseases such as cardio-cerebrovascular diseases. HuangqiGuizhiWuwu Decoction (HGWWD), classic Chinese prescription, mainly used to treat various vascular Although our previous studies reported that HGWWD could effectively prevent dysfunction in diabetic rodent models, the precise mechanism still elusive.In this study, we investigated mechanisms modulating damage endothelial cells diabetes by...
A novel multienzyme cascade was designed for the regio- and stereo-selective amination of renewable fatty acids to value-added d -amino acids.
Abstract A silver‐catalyzed cycloaromatization of 1‐(2‐ethynyl‐phenyl)‐prop‐2‐yn‐1‐ol with isocyanides efficiently provides benzo[ b ]fluorene and benzofuran‐pyrrole derivatives through a modular cascade reaction that includes nucleophilic attack on the diyne substrate. C−C cross‐coupling/oxygen transportation/Diels‐Alder/hydrogen shift/isomerization mechanistic pathway is proposed. magnified image
A copper-assisted Wittig-type olefination of aldehydes and p -toluenesulfonyl isocyanide (TosMIC) is disclosed, providing an operationally simple approach to ( E )-vinyl sulfone with various functional groups under mild reaction conditions.
A silver-mediated reaction between 2-ethynyl-3-(1-hydroxyprop-2-yn-1-yl)phenols or 2-ethynyl-3-(1-hydroxyprop-2-yn-1-yl)anilines and methylene isocyanides has been developed. sequential 5-endo-dig cyclization [3 + 2] cycloaddition process is proposed. This synthetic strategy atom- step-efficient applicable to a broad scope of substrates, allowing the synthesis valuable substituted benzofuran- indole-pyrroles in moderate high yields.
Polymyxin B (PB) is introduced into the clinic as last-line therapy against carbapenem-resistant