A5037712945- Pharmacological Effects of Natural Compounds
- Plant biochemistry and biosynthesis
- Microbial Metabolic Engineering and Bioproduction
- Natural product bioactivities and synthesis
- Chromatography in Natural Products
- Microbial Natural Products and Biosynthesis
- Enzyme Catalysis and Immobilization
- Olfactory and Sensory Function Studies
- Biochemical Analysis and Sensing Techniques
- Glycosylation and Glycoproteins Research
- Carbohydrate Chemistry and Synthesis
- Enzyme Production and Characterization
- Plant tissue culture and regeneration
- CRISPR and Genetic Engineering
- Biochemical and Molecular Research
- Regulation of Appetite and Obesity
- Toxin Mechanisms and Immunotoxins
- Phytochemical compounds biological activities
- Phytochemistry and Bioactivity Studies
- Fungal Biology and Applications
- Transgenic Plants and Applications
- Steroid Chemistry and Biochemistry
- Weed Control and Herbicide Applications
- Viral Infectious Diseases and Gene Expression in Insects
- Advanced Antenna and Metasurface Technologies
Ministry of Industry and Information Technology
2021-2025
Beijing Institute of Technology
2016-2025
Shanghai Electric (China)
2024
Hebei University
2024
Changchun Institute of Optics, Fine Mechanics and Physics
2024
Northwest A&F University
2019-2023
Harbin Engineering University
2023
China Academy of Information and Communications Technology
2022
Beijing Institute of Petrochemical Technology
2020-2021
Nanjing Agricultural University
2013-2020
The hallmark reaction of P450 monooxygenase involves activation C–H bond and the production a hydroxyl. P450s tailoring natural product could further oxidize hydroxyl to carboxylic acid. However, heterogeneously expressed plant display poor chemo- regioselectivity in microbes, restricting efficient biosynthesis related products. CYP72A63 is enzyme previously used for glycyrrhetinic acid, its selectivity resulted oxidation 11-oxo-β-amyrin mixture rare licorice triterpenoids (glycyrrhetol,...
An improved hybrid method of backward shooting and bouncing ray (SBR) physical optics (PO)/physical theory diffraction (PTD) is proposed to investigate the scattering from a three-dimensional electrically large target. The basic idea combine forward-ray-tracing technique accelerate original backward-ray-tracing one. significantly reduces computational complexity while ensuring same accuracy with traditional SBR method. performance our are validated evaluated by comparison exact...
Fosthiazate is a widely used chiral organophosphorous nematicide with four stereoisomers. The present study systemically assessed the stereoselectivity of fosthiazate for first time, including absolute configuration confirmation, stereoselective bioactivity toward nematode and aphid, toxicity to honeybees, degradation in cucumber pepper under field conditions. configurations stereoisomers that eluted on Superchiral IG-3 column were confirmed as (1S,3R)-(−)-fosthiazate,...
Yeast has been an indispensable host for synthesizing complex plant-derived natural compounds, yet the yields remained largely constrained. This limitation mainly arises from overlooking importance of cell and pathway suitability during optimization enzymes pathways. Herein, beyond conventional enzyme engineering, we dissected metabolic with a framework simultaneously augmenting cofactors carbon flux to enhance biosynthesis heterogenous triterpenoids. We further developed phospholipid...
Butenyl-spinosyn, derived from Saccharopolyspora pogona, is a broad-spectrum and effective bioinsecticide. However, the regulatory mechanism affecting butenyl-spinosyn synthesis has not been fully elucidated, which hindered improvement of production. Here, high-production strain S. pogona H2 was generated by Cobalt-60 γ-ray mutagenesis, showed 2.7-fold increase in production compared to wild-type ASAGF58. A comparative transcriptomic analysis between ASAGF58 performed elucidate that more...
Verbasoside and hydroxysalidroside are derivatives of phenylethanol glycosides (PhGs) that exhibit a range pharmacological activities also serve as valuable precursors for synthesizing other more complex PhGs. However, chemical synthesis plant extraction large-scale production impractical to date. Here, 79 fungi from four types PhG-containing plants their rhizospheric soils were screened out, endophyte Alternaria botrytis RYF1 Rehmannia glutinosa was identified with the ability generate...
The highly selective auxin-type herbicide quinclorac is widely used to control important dicotyledon and monocotyledon weeds in rice fields. Echinochloa crusgalli var. zelayensis one of the most troublesome China, very difficult east China due misuse herbicides.The JZD -R, JTJ JCW -R SSX biotypes E. had resistance with levels ranked as < -R. Growth reduction different was positively correlated ethylene production. Stimulated 1-aminocyclopropane-1-carboxylic acid (ACC) activities ACC synthase...
Compared to chemical methods, the biotransformation of glycyrrhizin (GL) into glycyrrhetinic acid 3- O -mono- β - d -glucuronide (GAMG), which has a higher sweetness and stronger pharmacological activity than those GL, via catalysis by -glucuronidase is an environmentally friendly approach due mild reaction conditions high yield GAMG. However, currently available GUSs show low substrate specificity toward GL further hydrolyze GAMG (GA) as by-product, increasing difficulty subsequent...
Glycoside hydrolases (GHs) have attracted special attention in research aimed at modifying natural products by partial removal of sugar moieties to manipulate their solubility and efficacy. However, these modifications are challenging control because the low substrate specificity most GHs often generates undesired by-products. We previously identified a GH2-type fungal β-glucuronidase from Aspergillus oryzae (PGUS) exhibiting promiscuous hydrolysis triterpenoid saponins. Here, we present...
Glycyrrhetinic acid (GA) is the pentacyclic triterpenoid hydrophobic aglycone with many pharmacological effects and biological activities. Glycosylation often used to improve aglycone's properties such as solubility, stability, potency. UDP-glycosyltransferases (UGTs) are main enzymes catalyze this conversion via transferring glycosyl moiety corresponding acceptor substrates in nature. However, a glycosyltransferase which can transfer glucose GA has not been reported yet. The UGT73C11 from...