Ke Chen

ORCID: 0000-0001-9089-7031
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About
Contact & Profiles
Research Areas
  • Biochemical Analysis and Sensing Techniques
  • Olfactory and Sensory Function Studies
  • Regulation of Appetite and Obesity
  • Receptor Mechanisms and Signaling
  • Advanced Chemical Sensor Technologies
  • Neuroscience and Neuropharmacology Research
  • Parkinson's Disease Mechanisms and Treatments
  • Hearing, Cochlea, Tinnitus, Genetics
  • Neurological disorders and treatments
  • Animal Vocal Communication and Behavior
  • Hearing Loss and Rehabilitation
  • Cognitive Abilities and Testing
  • Renin-Angiotensin System Studies
  • Neural dynamics and brain function
  • Neurobiology and Insect Physiology Research
  • Heart Rate Variability and Autonomic Control
  • Music Technology and Sound Studies
  • Blood Pressure and Hypertension Studies
  • Music and Audio Processing
  • Insect and Arachnid Ecology and Behavior
  • Optical Imaging and Spectroscopy Techniques
  • Speech and Audio Processing
  • advanced mathematical theories
  • Nonlinear Partial Differential Equations
  • Plant and animal studies

University of Chinese Academy of Sciences
2013-2025

State Key Laboratory of Transducer Technology
2025

Chinese Academy of Sciences
2013-2025

Shanghai Institute of Microsystem and Information Technology
2025

Harvard University
2023-2024

Massachusetts Eye and Ear Infirmary
2023-2024

Eaton (United States)
2023-2024

Stony Brook University
2018-2020

Xi'an Jiaotong University
2008-2019

State University of New York
2018

Visual, auditory, and somatosensory cortices are topographically organized, with neurons responding to similar sensory features clustering in adjacent portions of the cortex. Such topography has not been observed piriform cortex, whose responses odorants sparsely distributed across The spatial organization taste gustatory insular cortex (GC) is currently debated, conflicting evidence from anesthetized rodents pointing alternative mutually exclusive models. Here, we rely on calcium imaging...

10.1016/j.cub.2020.10.014 article EN cc-by-nc-nd Current Biology 2020-11-12

Research over the past decade has established gustatory insular cortex (GC) as a model for studying how primary sensory cortices integrate sensory, affective, and cognitive signals. This integration occurs through time-varying patterns of neural activity. Selective silencing GC activity during specific temporal windows provided evidence GC's role in mediating taste palatability expectation. Recent results also suggest that this area may play decision making. However, existing data are...

10.1016/j.cub.2020.03.012 article EN cc-by-nc-nd Current Biology 2020-04-02

This study investigated the disparities in brain activation patterns during Stroop task among individuals with mild cognitive impairment (MCI) and those without any impairments (healthy controls, HCs) using functional near-infrared spectroscopy (fNIRS). We analyzed cortical of 73 patients MCI 63 HC as they completed task, employing fNIRS. The regions interest (ROIs) included dorsal prefrontal cortex (dPFC), ventrolateral (VLPFC), parietal lobe (PL). is divided into early stage (0-15 s) late...

10.3389/fnagi.2025.1470747 article EN cc-by Frontiers in Aging Neuroscience 2025-02-07

Objectives: This study aimed to investigate how motor preparation impacted brain activation in individuals with differing cognitive statuses. Methods: We investigated the cortical pattern of 57 mild impairment (MCI) and 67 healthy controls (HCs) using functional near-infrared spectroscopy (fNIRS) during prepared walking (PW) single (SW) tasks. The focused on assessing activity four regions interest (ROIs): prefrontal cortex (PFC), primary cortex, secondary parietal lobe. Additionally, we...

10.3390/brainsci15040333 article EN cc-by Brain Sciences 2025-03-23

10.1016/j.bbrc.2013.05.036 article EN Biochemical and Biophysical Research Communications 2013-05-21

Dysfunction of motor cortices is thought to contribute disorders such as Parkinson's disease (PD). However, little known on the link between cortical dopaminergic loss, abnormalities in cortex neural activity and deficits. We address role dopamine modulating by focusing anterior lateral (ALM) mice performing a cued-licking task. first demonstrate licking deficits concurrent alterations spiking ALM head-fixed with unilateral depletion neurons (i.e., injected 6-OHDA into medial forebrain...

10.1093/cercor/bhz005 article EN cc-by-nc Cerebral Cortex 2019-01-08

SUMMARY Research over the past decade has established gustatory insular cortex (GC) as a model for studying how primary sensory cortices integrate multiple sensory, affective and cognitive signals. This integration occurs through time varying patterns of neural activity. Selective silencing GC activity during specific temporal windows provided evidence GC’s role in mediating taste palatability expectation. Recent results also suggest that this area may play decision making. However, existing...

10.1101/2019.12.16.878553 preprint EN cc-by-nc-nd bioRxiv (Cold Spring Harbor Laboratory) 2019-12-18

Managing the emotional aspect remains a challenge in automatic music generation. Prior works aim to learn various emotions at once, leading inadequate modeling. This paper explores disentanglement of piano performance generation through two-stage framework. The first stage focuses on valence modeling lead sheet, and second addresses arousal by introducing performance-level attributes. To further capture features that shape valence, an less explored previous approaches, we introduce novel...

10.48550/arxiv.2407.20955 preprint EN arXiv (Cornell University) 2024-07-30

In this paper, we establish local well-posedness results for the Muskat equation in any dimension using modulus of continuity techniques. By introducing a novel quantity \(\beta_\sigma(f_0')\) which encapsulates monotonicity and slope, identify new class initial data within \(W^{1,\infty}(\mathbb{R}^d)\). This includes scenarios where product maximal minimal slopes is large, thereby guaranteeing existence classical solution.

10.48550/arxiv.2411.01501 preprint EN arXiv (Cornell University) 2024-11-03

SUMMARY Sound elicits rapid movements of muscles in the face, ears, and eyes that protect body from injury trigger brain-wide internal state changes. Here, we performed quantitative facial videography mice resting atop a piezoelectric force plate observed broadband sounds elicit rapid, small, highly stereotyped region near vibrissae array. Facial motion energy (FME) analysis revealed sensitivity to far lower sound levels than acoustic startle reflex greater reliability across trials...

10.1101/2023.09.07.556766 preprint EN cc-by-nc-nd bioRxiv (Cold Spring Harbor Laboratory) 2023-09-09

SUMMARY Visual, auditory and somatosensory cortices are topographically organized, with neurons responding to similar sensory features clustering in adjacent portions of the cortex. Such topography has not been observed piriform cortex, whose responses odorants sparsely distributed across The spatial organization taste gustatory insular cortex (GC) is currently debated, conflicting evidence from anesthetized rodents pointing alternative mutually exclusive models. Here, we rely on calcium...

10.1101/2020.07.01.183095 preprint EN cc-by-nc-nd bioRxiv (Cold Spring Harbor Laboratory) 2020-07-02

ABSTRACT Dysfunction of motor cortices is thought to contribute disorders such as Parkinson’s disease (PD). However, little known on the link between cortical dopaminergic loss, abnormalities in cortex neural activity and deficits. We address role dopamine modulating by focusing anterior lateral (ALM) mice performing a cued-licking task. first demonstrate licking deficits concurrent alterations spiking ALM with unilateral depletion neurons (i.e., injected 6-OHDA into medial forebrain...

10.1101/337014 preprint EN cc-by-nc bioRxiv (Cold Spring Harbor Laboratory) 2018-06-03
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