A5027813231- Intracranial Aneurysms: Treatment and Complications
- Traumatic Brain Injury and Neurovascular Disturbances
- Renal cell carcinoma treatment
- Lung Cancer Diagnosis and Treatment
- S100 Proteins and Annexins
- Cancer-related molecular mechanisms research
- Lung Cancer Treatments and Mutations
- Ferroptosis and cancer prognosis
- Lung Cancer Research Studies
- Epigenetics and DNA Methylation
- Renal and related cancers
- Pancreatic and Hepatic Oncology Research
- Cerebrovascular and Carotid Artery Diseases
- Electrospun Nanofibers in Biomedical Applications
- Intracerebral and Subarachnoid Hemorrhage Research
- RNA modifications and cancer
- Vascular Malformations Diagnosis and Treatment
- Tracheal and airway disorders
- Cancer, Lipids, and Metabolism
- Natural Compounds in Disease Treatment
- Rheumatoid Arthritis Research and Therapies
- Prostate Cancer Treatment and Research
- Cancer-related Molecular Pathways
- Cancer-related gene regulation
- Moyamoya disease diagnosis and treatment
Shanghai Institute of Technology
2024
Sichuan University
2021-2024
Imperial College Healthcare NHS Trust
2021-2024
Charing Cross Hospital
2022-2024
West China Hospital of Sichuan University
2021-2024
First Affiliated Hospital of Zhengzhou University
2015-2024
Jiaxing University
2011-2023
First Hospital of Jiaxing
2016-2023
Chongqing University of Education
2022-2023
Zhongshan Hospital
2023
Intracranial aneurysm is a leading cause of stroke. Its treatment has evolved over the past 2 decades. This review summarizes strategies for intracranial aneurysms from 3 different perspectives: open surgery approach, transluminal and new technologies being used or trialed. We introduce most available techniques in detail, including contralateral clipping, wrapping double catheters assisting coiling waffle-cone technique, so on. Data major trials such as Analysis Treatment by Endovascular...
We aimed to assess the association between triglyceride-glucose (TyG) index and kidney stones in US adults.Data were obtained from 2007-2014 National Health Nutrition Examination Survey (NHANES). Participants aged ≥18 years who not pregnant provided complete data about TyG included analysis. Weighted multivariable regression analysis subgroup preformed estimate independent relationship nephrolithiasis recurrence.A total of 20,972 participants with mean 8.71 ± 0.72. The prevalence rates...
Interstitial lung disease (ILD) is associated with substantial morbidity and mortality, which one of the key systematic manifestations connective tissue (CTD). Tripterygium wilfordii, known as Leigongteng in Chinese, has been applied to treat disease-related interstitial (CTD-ILD) for many years. Triptolide a effective component from wilfordii. But molecular mechanism treating CTD-ILD not yet clear.Gaining insight into intervention CTD-ILD, we used method network pharmacology. And then...
Abstract Systemic metabolic syndrome significantly increases the risk of morbidity and mortality in patients with non-alcoholic fatty liver disease (NAFLD) steatohepatitis (NASH). However, no effective therapeutic strategies are available, practically because our understanding its complicated pathogenesis is poor. Here we identify tripartite motif-containing protein 31 (Trim31) as an endogenous inhibitor rhomboid 5 homolog 2 (Rhbdf2), further determine that Trim31 directly binds to Rhbdf2...
We investigated the relationship between low lean mass (LLM) and lower urinary tract symptoms (LUTS) using 2005â2006 National Health Nutrition Examination Survey (NHANES) dataset. enrolled 959 men with an average age of 52.08 ± 7.91 years performed weighted multiple regression analysis to determine independent exposure variables (LLM, alternate LLM) outcomes (urinary hesitancy, incomplete emptying, frequency, nocturia, daytime LUTS, clinical LUTS) after adjusting for confounding factors....
Traumatic brain injury (TBI) is the leading cause of death in young adults and main mortality disability across all ages worldwide. We previously analyzed expression profile data TBI models obtained from Gene Expression Omnibus (GEO) database found that seripina3n mRNA was markedly upregulated acute phase four sets, indicating serpina3n may be involved pathophysiological process TBI. Therefore, we further investigated biological role molecular mechanism traumatic this study. As a result,...
The molecular pathogenesis of human lung cancer has not been completely clarified. Here, we reported that UBE2L3, a member the ubiquitin-conjugating enzymes (E2s), were overexpressed in non-small-cell (NSCLC) tissues compared with non-tumor tissues. High expression UBE2L3 was correlated advanced tumor stage and adverse outcomes. Knockdown inhibited NSCLC cell growth while ectopic promoted cycle dependent manner. results subcutaneous xenograft studies revealed knockdown attenuated vivo...
miR-301b-3p is reported in various human cancers for its abnormal expression, while the role and molecular mechanisms lung adenocarcinoma (LUAD) remain unclear, this focus of present study.TCGA database was consulted to know gene expression LUAD tissue. CCK-8, colony formation assay Transwell were applied identify target genes regulating cell biological properties. Bioinformatics analysis plus dual-luciferase performed validate potential connection between genes.miR-301b-3p DLC1 study...
The aim of the present study was to investigate functions RNA polymerase I subunit B (POLR1B) in lung cancer. Reverse transcription-quantitative PCR used measure mRNA expression level POLR1B human cancer cell lines including A549, NCI-H1299, NCI-H1975 and NCI-H460. A lentivirus vector transfection system knockdown A549 cells. Celigo Cell Counting method, MTT colony formation assays were proliferation knocking-down Flow cytometry assay apoptosis rates. Co-expression analysis microarray...
Clear cell renal carcinoma (ccRCC) is the dominant subtype of kidney cancer. Dysregulation long-chain acyl-CoA synthetase 1 (ACSL1) strongly implicated in undesirable results varieties cancers. Nevertheless, dysregulation and associated multi-omics characteristics ACSL1 ccRCC remain elusive.We probed mRNA protein profiles RCC using data from Cancer Genome Atlas, Gene Expression Omnibus, Human Protein Atlas (HPA), Clinical Proteomic Tumor Analysis Consortium (CPTAC) verified them our patient...
This study was to test the hypothesis that tetramethylpyrazine (TMP) protected against early brain injury after subarachnoid hemorrhage (SAH) by affecting mitochondrial-dependent caspase-3 apoptotic pathway. TMP administrated rats' prechiasmatic SAH mode. Animal neurobehavioral functions were assessed and mitochondrial morphology, cytoplasmic calcium, membrane potential changes (Δψm) of tissues measured. The expressions cytochrome c (cyt c), second mitochondria-derived activator caspases...