A5103247619- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Flavonoids in Medical Research
- RNA modifications and cancer
- Liver physiology and pathology
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Cancer Research and Treatments
- Natural product bioactivities and synthesis
- HER2/EGFR in Cancer Research
- Virus-based gene therapy research
- Peptidase Inhibition and Analysis
- Cancer-related gene regulation
- Cancer Mechanisms and Therapy
- Immune cells in cancer
- Cancer-related Molecular Pathways
- Stress Responses and Cortisol
- Lung Cancer Treatments and Mutations
- Hepatitis B Virus Studies
- Cancer Cells and Metastasis
- Lung Cancer Research Studies
- Colorectal Cancer Treatments and Studies
- Chemokine receptors and signaling
- Phagocytosis and Immune Regulation
- Cancer Immunotherapy and Biomarkers
Second Affiliated Hospital of Guangzhou Medical University
2008-2025
Second Affiliated Hospital of Xi'an Jiaotong University
2015-2024
Guangzhou Medical University
2008-2024
Xi'an Jiaotong University
2004-2023
Xiamen University
2021
Shanghai Chest Hospital
2021
Shanghai Jiao Tong University
2021
Weatherford College
2021
Shaanxi Provincial People's Hospital
2017-2018
Shanxi Medical University
2017-2018
Baicalein, a widely used Chinese herbal medicine, has historically been in anti-inflammatory and anti-cancer therapies. However, the anti-metastatic effect molecular mechanism(s) of baicalein on hepatocellular carcinoma (HCC) remain poorly understood. Therefore, purpose this study was to assess effects related HCC. Based assays utilized both HCC cell lines an animal model, we found that inhibited tumor metastasis vivo vitro. Furthermore, after treatment with for 24 hours, there decrease...
Baicalein is a purified flavonoid extracted from the roots of Scutellaria baicalensis or radix. Although previous studies have suggested that possesses an in vitro anti-hepatocellular carcinoma activity, its vivo effects and mechanisms action are still not completely understood. In this study, at concentrations 40-120 µM exhibited significant cytotoxicity to three hepatocellular (HCC) cell lines but marginal normal liver line vitro. Compared standard chemotherapy drug, 5-fluorouracil (5-FU),...
Baicalein has been shown to possess significant anti-hepatoma activity by inhibiting cell proliferation. Whether the anti-proliferative effect of baicalein is related its modulation miRNA expression in hepatocellular carcinoma (HCC) still unknown.The effects on HCC line Bel-7402 was assessed detecting proliferation activity, cycle distribution, changes p21/CDKN1A, P27/CDKN1B, total Akt and phosphoryted AKT. Microarray analysis conducted determine profiles baicalein-treated or untreated cells...
Abstract Psychological stress has great impacts on the immune system, particularly leukocytes distribution. Although of acute blood distribution are well studied, however, it remains unclear how chronic affects in peripheral circulation. Furthermore, there is no report about role spleen induced by stress. Here we show that contributes to alteration restraint Our data confirmed anxiety-like behavior mice. found decreased CD4/CD8 ratio and elevated percentages natural killer cells, monocytes...
Liver fibrosis is a complex process of tissue remodeling in response to injury. Hepatic macrophages have been identified as key player this process. As the largest lymphoid organ body, spleen exerts both local and systemic effects on immune cell response. Splenectomy can improve hepatic function during treatment liver cirrhosis. However, whether influences disease progression through modulation remains unclear.We examined ex vivo macrophage responses from splenectomized or sham operated rats...
WXSH0208 is a selective inhibitor of influenza RNA polymerase subunit, demonstrating antiviral activity in preclinical studies against A and B virus infections. The purpose this study was to investigate the efficacy safety adult outpatients with uncomplicated influenza. We conducted multicenter phase 2 trial based on randomized, double-blind, placebo-controlled design at 23 research centers China from November 2023 March 2024. Participants were randomized 1:1:1:1 receive one following...
Recurrence of bladder cancer following transurethral resection tumor (TURBt) is an obstacle in clinical management. In the current study, we investigated antitumor activity baicalein, a Chinese herbal medicine, against T24 cells vitro. Baicalein inhibited growth and caused G1/S arrest cell cycle cells. Moreover, baicalein induced apoptosis via loss mitochondrial transmembrane potential (ΔΨm), release cytochrome c activation caspase-9 caspase-3. Akt phosphorylation, downregulated Bcl-2...
EGR1 plays a critical role in cancer progression. However, its precise hepatocellular carcinoma has not been elucidated. In this study, we found that the overexpression of suppresses cell proliferation and increases apoptosis by binding to miR-203a promoter sequence. addition, investigated function on progression HCC cells. We verified effect is consistent with regulation Through bioinformatic analysis luciferase assays, confirmed targets HOXD3. Silencing HOXD3 could block transition G2/M...
The dynamics of the spleen during tumor progression remains incompletely understood. In this study, we established a murine H22 orthotopic hepatoma model and dynamically detected alterations in percentages immunocytes spleen. We observed prominent myeloid-derived suppressor cell (MDSC) accumulation early response which persisted through all stages growth. addition, percentage regulatory T cells (Tregs) increased by week 2. Although CD3 + CD49b natural killer (NKT) day 3, that CD4 slightly 1,...
The high mortality figures for hepatocellular carcinoma (HCC) are mostly due to recurrence and metastasis rates. However, the metabolic characteristics of HCC have not been studied extensively. In this study, we attempted elucidate metabolite profile formation through proton nuclear magnetic resonance (1H-NMR)-based metabolomics. We first established a with lung (HLM) rat model by exposure diethylnitrosamine. Fifteen rats were then divided into three groups based on pathologic changes: HCC,...
Hypersplenism is a condition in which the spleen overactive. It common patients with cirrhosis-related portal hypertension. The over-activated hemophagocytic splenic macrophages are an important cause of hypersplenism. MicroRNAs (miRNAs) 21-22 nt single-stranded RNAs expressed endogenously, play roles many diseases. We have found by microarray, previously, that miR-615-3p highly In this study, we enhanced phagocytic capacity macrophages. Bioinformatics analysis indicated ligand-dependent...
Abstract Background Among the most aggressive and rapidly lethal types of lung cancer, adenocarcinoma is common type. Exosomes, as a hot area, play an influential role in cancer. By using proteomics analysis, we aimed to identify potential markers serum. Methods In our study, used ultracentrifugation method isolate serum exosomes. The Liquid chromatography-mass spectrometry (LC–MS) bioinformatics analysis were exosomal proteins with altered expression among patients advanced adenocarcinoma,...
gastric cancer is a serious health concern with high morbidity and mortality. Therefore, it urgent to find novel targets for diagnosis treatment.qRT-PCR immunohistochemistry assays were used detect GTPBP4 expression in tissues, epithelial cells. Lentivirus infection was construct stable knockdown Annexin V/PI apoptosis, CCK8, EdU incorporation cell clone formation analysis performed evaluate the effects of on proliferation apoptosis. Further RNA-based high-throughput sequencing co-IP...
Abstract Hepatocarcinoma (HCC) has a very high mortality rate and the recurrence metastasis rates contribute to poor prognosis of HCC patients. To understand formation metastasis, we assessed metabonomics rat with lung (HLM). The HLM model was established by exposure diethylnitrosamine (DEN). Levels serum urine metabolites were quantified gas chromatography/time‐of‐flight mass spectrometry (GC/TOFMS), data analyzed partial least‐squares discrimination analysis (PLS‐DA). Serum levels some...