A5101580545- Dark Matter and Cosmic Phenomena
- Lung Cancer Treatments and Mutations
- Cancer, Hypoxia, and Metabolism
- Particle Detector Development and Performance
- Astrophysics and Cosmic Phenomena
- Cancer Cells and Metastasis
- Brain Metastases and Treatment
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
- Cancer Genomics and Diagnostics
- Ferroptosis and cancer prognosis
- Cancer Immunotherapy and Biomarkers
- Cancer Research and Treatments
- Glioma Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Colorectal Cancer Treatments and Studies
- Gastric Cancer Management and Outcomes
- Photoacoustic and Ultrasonic Imaging
- RNA modifications and cancer
- Inflammatory Bowel Disease
- Nanoplatforms for cancer theranostics
- HER2/EGFR in Cancer Research
- Renal Diseases and Glomerulopathies
- Radiation Therapy and Dosimetry
- 3D Printing in Biomedical Research
Houston Methodist
2016-2025
Harbin Medical University
2015-2025
Daqing City People's Hospital
2025
Sun Yat-sen University
2021-2025
Fifth Affiliated Hospital of Sun Yat-sen University
2025
Children's Hospital of Zhejiang University
2014-2025
Tongji Hospital
1991-2025
Huazhong University of Science and Technology
2003-2025
University of Electronic Science and Technology of China
2025
The Fourth People's Hospital
2025
Triple-negative breast cancer (TNBC) is an aggressive form of with no effective targeted therapy. Inducible nitric oxide synthase (iNOS) associated poor survival in patients by increasing tumor aggressiveness. This work aimed to investigate the potential iNOS inhibitors as a therapy for TNBC. We hypothesized that inhibition endogenous would decrease TNBC aggressiveness reducing initiation and metastasis through modulation epithelial-mesenchymal transition (EMT)-inducing factors.iNOS protein...
On April 29, 2014, the FDA granted accelerated approval to ceritinib (ZYKADIA; Novartis Pharmaceuticals Corporation), a breakthrough therapy-designated drug, for treatment of patients with anaplastic lymphoma kinase (ALK)-positive, metastatic non-small cell lung cancer (NSCLC) who have progressed on or are intolerant crizotinib. The was based single-arm multicenter trial enrolling 163 ALK-positive NSCLC had disease progression (91%) intolerance Patients received at starting dose 750 mg...
Abstract Triple negative breast cancer (TNBC) is known to contain a high percentage of CD44+/CD24−/low stem cells (CSCs), corresponding with poor prognosis despite systemic chemotherapy. Chloroquine (CQ), an antimalarial drug, lysotropic reagent which inhibits autophagy. CQ was identified as potential CSC inhibitor through in silico gene expression signature analysis the population. Autophagy plays critical role adaptation stress conditions cells, and related drug resistance maintenance....
Abstract On December 11, 2015, the FDA granted accelerated approval to alectinib (Alecensa; Genentech) for treatment of patients with anaplastic lymphoma receptor tyrosine kinase (ALK)-positive, metastatic non–small cell lung cancer (NSCLC) who have progressed on or are intolerant crizotinib. This was based two single-arm trials including 225 treated 600 mg orally twice daily. The objective response rates (ORR) by an independent review committee in these studies were 38% [95% confidence...
Abstract Intrauterine adhesion (IUA) stands as a prevalent medical condition characterized by endometrial fibrosis and scar tissue formation within the uterine cavity, resulting in infertility and, severe cases, recurrent miscarriages. Cell therapy, especially with stem cells, offers an alternative to surgery, but concerns about uncontrolled differentiation tumorigenicity limit its use. Exosomes, more stable immunogenicity‐reduced than parent have emerged promising avenue for IUA treatment....
Discoidin domain receptor 2 (DDR2) is an unusual tyrosine kinase in that its ligand fibrillar collagen rather than a growth factor-like peptide. We examined signal transduction pathways of DDR2. Here we show DDR2 also it requires Src activity to be maximally tyrosine-phosphorylated, and promotes association with Shc. The interaction Shc involves portion not previously implicated kinases. These results identify the adaptor protein as key signaling intermediates transduction. Furthermore,...
Little research has been done to address the huge opportunities that may exist reposition existing approved or generic drugs for alternate uses in cancer therapy. In addition, there little work on strategies experimental agents testing settings could shorten their clinical development time. Progress each area lagged, part, because of lack systematic methods define drug off-target effects (OTE) might affect important cell signaling pathways. this study, we addressed critical gap by developing...
Abstract Purpose: Irinotecan (CPT-11) induced diarrhea occurs frequently in patients with cancer and limits its usage. Bacteria β-glucuronidase (GUS) enzymes intestines convert the nontoxic metabolite of CPT-11, SN-38G, to toxic SN-38, finally lead damage intestinal epithelial cells diarrhea. We previously reported amoxapine as a potent GUS inhibitor vitro. To further understand molecular mechanism potential for treatment CPT-11–induced diarrhea, we studied binding modes metabolites by...
Segmented filamentous bacteria (SFB) are commensal organisms which grow by anchoring a specialized holdfast structure to the intestinal walls of variety animals. Interaction SFB with Peyer's patches in mice promotes post-natal maturation immune system. We previously reported that colonization humans mainly occurs 36 months age, and is difficult be detected afterwards. In this study, we measured level fluids human children. were found via qPCR represent small fraction whole SFB-positive...
Breast carcinoma (BC) has been extensively profiled by high-throughput technologies for over a decade, and broadly speaking, these studies can be grouped into those that seek to identify patient subtypes (studies of heterogeneity) or gene signatures with prognostic predictive capacity. The sheer number reported led speculation everything is in BC. Here, we show this ubiquity an apparition caused poor understanding the interrelatedness between subtype molecular determinants prognosis. Our...
The activation of the epithelial-to-mesenchymal transition (EMT) program is a critical step in cancer progression and metastasis, but visualization this process at single-cell level, especially vivo, remains challenging. We established an vivo approach to track fate tumor cells based on novel EMT-driven fluorescent color switching breast mouse model intravital two-photon laser scanning microscopy. Specifically, MMTV-PyMT, Rosa26-RFP-GFP, Fsp1-Cre triple transgenic was used monitor conversion...
Triple-negative breast cancer (TNBC) exhibits more traits possessed by stem cells (CSC) than other subtypes and is likely to develop brain metastases. TNBC patients usually have shorter survival time after diagnosis of metastasis, suggesting an innate ability tumor in adapting the brain. In this study, we establish novel animal models investigate early adaptation metastases introducing both patient-derived cell line-derived CSC-enriched metastasis tumorsphere into mice. We discovered...
Systematic drug repositioning identifies digoxin as a potential treatment for groups 3 and 4 medulloblastoma.
Abstract Background Regulatory T cells (Tregs) play a neuroprotective role by suppressing microglia and macrophage-mediated inflammation modulating adaptive immune reactions. We previously documented that Treg immunomodulatory mechanisms are compromised in Alzheimer’s disease (AD). Ex vivo expansion of Tregs restores amplifies their immunosuppressive functions vitro. A key question is whether adoptive transfer ex expanded human can suppress neuroinflammation amyloid pathology preclinical...
Abstract Lung cancer is the leading cause of cancer-related deaths and has an overall 5-year survival rate lower than 15%. Large-scale clinical trials have demonstrated a significant relative reduction in mortality high-risk individuals with low-dose computed tomography screening. However, biomarkers capable identifying most at-risk population detecting lung before it becomes clinically apparent are urgently needed clinic. Here, we report identification urine cancer. Using well-characterized...
Triple-negative breast cancers (TNBCs) display a complex spectrum of mutations and chromosomal aberrations. Chromosome 5q (5q) loss is detected in up to 70% TNBCs, but little known regarding the genetic drivers associated with this event. Here, we show somatic deletion region syntenic human 5q33.2–35.3 mouse model TNBC. Mechanistically, identify KIBRA as major factor contributing effects on tumor growth metastatic progression. Re-expression impairs metastasis vivo inhibits tumorsphere...
// Xiaoping Zhu 1, * , Jing Zhong 2, Zhen Zhao 3 Jianting Sheng 1 Jiang Wang 4 Jiyong Liu 5 Kemi Cui Jenny Chang 6 Hong Stephen Wong Department of Systems Medicine and Bioengineering, Houston Methodist Research Institute, Weill Cornell Medical College, Houston, TX, USA 2 Radiology, The Teaching Hospital Fujian University, Provincial Cancer Hospital, Fuzhou, China Zhongda Nanjing, Orthopedics, Tongji Wuhan, Pharmacy, Changhai Shanghai, Center, These authors have contributed equally to this...
Endothelial cells are known to contribute kidney fibrosis via endothelial-mesenchymal transition (EndoMT). Matrix metalloproteinase 9 (MMP-9) is be profibrotic. However, whether MMP-9 contributes EndoMT unknown.Primary mouse renal peritubular endothelial (MRPECs) were isolated and treated by recombinant human transforming growth factor beta 1 (rhTGF-β1) with or without inhibitor (rhMMP-9) alone. Kidney was induced unilateral ureteral obstruction (UUO) in knockout (KO) wide-type (WT) control...
Abstract Subsets of breast tumors present major clinical challenges, including triple-negative, metastatic/recurrent disease and rare histologies. Here, we developed 37 patient-derived xenografts (PDX) from these difficult-to-treat cancers to interrogate their molecular composition functional biology. Whole-genome transcriptome sequencing reverse-phase protein arrays revealed that PDXs conserve the landscape corresponding patient tumors. Metastatic potential varied between PDXs, where...
Abstract The increasing rates of antibiotic resistance in Helicobacter pylori ( H. ) are a major concern the decreasing eradication rate. Large-scale and long-period studies on antimicrobial susceptibility children limited. This study aimed to describe temporal changes among southeast China. Gastric biopsies obtained from were cultured for 2015 2020. Susceptibility clarithromycin (CLA), amoxicillin (AML), metronidazole (MTZ), furazolidone (FZD), tetracycline (TET) levofloxacin (LEV) was...
Abstract BACKGROUND: Brain‐metastatic breast cancer (BMBC) is increasing and poses a severe clinical problem because of the lack effective treatments underlying molecular mechanisms are largely unknown. Recent work has demonstrated that deregulation epidermal growth factor receptor (EGFR) may correlate with BMBC progression. However, exact contribution EGFR makes to remains unclear. METHODS: The role in was explored by serial analyses brain‐trophic clone human MDA‐MB‐231 carcinoma cells...