A5011099443- Diet and metabolism studies
- Diabetes and associated disorders
- Metabolism, Diabetes, and Cancer
- Diabetes Treatment and Management
- Liver Disease Diagnosis and Treatment
- Pancreatic function and diabetes
- Diabetes Management and Research
- Immunotherapy and Immune Responses
- Atherosclerosis and Cardiovascular Diseases
- Neuropeptides and Animal Physiology
- Pancreatitis Pathology and Treatment
- Cerebrovascular and Carotid Artery Diseases
- Nutrition and Health in Aging
- Advanced Neuroimaging Techniques and Applications
- Diet, Metabolism, and Disease
- RNA Interference and Gene Delivery
- Metabolomics and Mass Spectrometry Studies
- Bone health and osteoporosis research
- Adipose Tissue and Metabolism
- Immune Cell Function and Interaction
- Advanced MRI Techniques and Applications
- Chronic Kidney Disease and Diabetes
- Gout, Hyperuricemia, Uric Acid
- Regulation of Appetite and Obesity
- Characterization and Applications of Magnetic Nanoparticles
Pudong Medical Center
2018-2025
Fudan University
2018-2025
Hebei Medical University
2025
University of California, San Francisco
2023
Heilongjiang Bayi Agricultural University
2023
First Affiliated Hospital of Anhui Medical University
2023
Anhui Medical University
2023
Zunyi Medical University
2023
Pudong New Area People's Hospital
2023
Tianjin Medical University Cancer Institute and Hospital
2017
Previous research has shown that type 2 diabetes mellitus (T2DM) is associated with an increased risk of cognitive impairment. Patients impaired cognition often show decreased spontaneous brain activity on resting-state functional magnetic resonance imaging (rs-fMRI). This study used rs-fMRI to investigate changes in among patients T2DM and determine the relationship these (n = 29) age-, sex-, education-matched healthy control subjects 27) were included this study. Amplitude low-frequency...
Abstract A practical and effective strategy for synthesizing PEGylated superparamagnetic iron oxide nanoparticles (SPIONs) is established. In this strategy, poly(acrylic acid) (PAA) combined with SPIONs via multiple coordination between the carboxylic groups of PAA SPIONs, which introduces abundant groups, then, α , ω ‐diamino PEG linked to amidation groups. The synthesized exhibit no cytotoxicity high resistance phagocytosis by macrophages in vitro as well low uptake liver spleen vivo,...
It is found that Prussian Blue nanoparticles (PBNPs) possess a catalase-like activity to catalyse the breakdown of H2O2 into oxygen (O2) molecules under neutral conditions (pH = 7.4). Based on this finding, we have developed new strategy in which PBNPs can be excellent ultrasound (US) and magnetic-resonance (MR) dual modality imaging contrast agents for diagnostics vitro vivo. Detailed facts importance specialist readers are published as "Supporting Information". Such documents...
Type 2 diabetes is characterized by insulin resistance, which involved in the development of Alzheimer disease. This study aims to investigate relationship between abnormal resting-state brain functional connectivity and resistance type diabetes.A total 30 patients with 31 healthy well-matched volunteers were prospectively examined. Resting-state analysis was used examine correlation posterior cingulate cortex (PCC) whole-brain regions. The possible relationships measures evaluated using...
AimsRecently, interleukin (IL)-9 was found to be involved in the pathogenesis of many inflammatory diseases. Here, we tested whether IL-9 related atherosclerosis and investigated underlying mechanisms.
This study investigates the possible effect and central mechanism of novel antidiabetic medication sodium glucose transporter-2 (SGLT-2i) on cardiovascular activity.Thirty-four normal male C57BL/6 mice were randomly assigned to 2 groups receive single Dapagliflozin (1.52mg/kg) dose via intragastric gavage or a comparable saline. Glycemic level (BG), blood pressure (BP) heart rate (HR) measured hours after administration respective treatments. Immunohistochemical tests performed determine...
Direct Observation of Procedural Skills (DOPS) is a clinical assessment tool that enables trainers to observe medical students' procedural abilities in real-time settings. It assesses knowledge application, decision-making, and skill proficiency during tasks. This study modifies the DOPS evaluate operation insulin pumps (PUMP) continuous glucose monitoring systems (CGMS) diabetes management. Key elements modified include 1) Knowledge Assessment: Evaluating understanding PUMP CGMS, including...
To develop a 9-dye fluorescent autosomal and Y chromosome STR multiplex amplification system verify its performance. Using the labeling technology, construct that uses core preferred loci recommended by GB/T 41009-2021 national standard as candidate loci, then evaluate accuracy, sensitivity, species specificity, other performance index. A containing 70 including Amel, D5S818, D21S11, D7S820, CS1FPO, D2S1338, D19S433, D8S1132, D2S441, VWA, D8S1179, D16S539, D10S1435, PentaD, D3S3045, TPOX,...
Abstract BACKGROUND: Brain‐metastatic breast cancer (BMBC) is increasing and poses a severe clinical problem because of the lack effective treatments underlying molecular mechanisms are largely unknown. Recent work has demonstrated that deregulation epidermal growth factor receptor (EGFR) may correlate with BMBC progression. However, exact contribution EGFR makes to remains unclear. METHODS: The role in was explored by serial analyses brain‐trophic clone human MDA‐MB‐231 carcinoma cells...
Spatial interaction and connectivity are important factors in the spread of infectious diseases. We developed a spatial-temporal model schistosomiasis japonica transmission, disease caused by parasites that transported via surface water live both snail human hosts. The employed spatial matrix based on neighborhood relationships hydrologic to assess effect intervillage parasitic transport transmission control. Satellite remote-sensing data served as input for predicting density within each...
A strategy for conjugating an antitumor agent to superparamagnetic iron oxide nanoparticles (SPIONs) via a biocleavable ester binding is reported. Paclitaxel (PTX) was selected as model drug. Both the in vitro and vivo performance of conjugates SPION-PTX investigated respectively. PTX can be released slowly through hydrolysis bond pH-dependent manner has near equal cytotoxity clinical injection (Taxol) at equivalent dose PTX. Furthermore, accumulate tumor tissues demonstrated by MRI exhibit...
Abstract Background Nonalcoholic fatty liver disease (NAFLD) is primarily characterized by the hepatic cholesterol accumulation. Circular RNA (circRNA), one of noncoding RNA, involves in many diseases progression. However, no recent studies on circRNA expression profiles NAFLD have been reported previously. Methods A mouse model was constructed providing high-fat diet (HFD) for 32 weeks. The circRNAs profile normal mice and were determined using high-output sequencing method bioinformatics...
Atherosclerotic disease is a leading cause of morbidity and mortality in developed countries, oxidized LDL (OxLDL) plays key role the formation, rupture, subsequent thrombus formation atherosclerotic plaques. In current study, anti-mouse OxLDL polyclonal antibody nonspecific IgG were conjugated to polyethylene glycol-coated ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles, carotid perivascular collar model apolipoprotein E-deficient mice was imaged at 7.0 Tesla MRI before...
Backgrounds and Objective: Diabetic foot is a relatively severe complication in patients with type 2 diabetes (T2D), peripheral neuropathy angiopathy frequently serving as risk factors. However, it unknown how the other major systemic metabolic factors impacted profile of these patients, besides glucose management. Thus, we investigated distinct characteristics diabetic ulcers their relationships angiopathy. Materials Methods: We obtained laboratory data 334 at Shanghai Pudong Hospital from...