A5100324121- Fibroblast Growth Factor Research
- Metabolism, Diabetes, and Cancer
- Heme Oxygenase-1 and Carbon Monoxide
- Cancer-related molecular mechanisms research
- Diet, Metabolism, and Disease
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Epigenetics and DNA Methylation
- Alcohol Consumption and Health Effects
- Connexins and lens biology
- Neuroscience of respiration and sleep
- Liver Disease Diagnosis and Treatment
- Advanced biosensing and bioanalysis techniques
- Pancreatic function and diabetes
- Ion channel regulation and function
- Lipid metabolism and disorders
- Ginseng Biological Effects and Applications
- Microbial metabolism and enzyme function
- Genomics, phytochemicals, and oxidative stress
- Glycosylation and Glycoproteins Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Lipid metabolism and biosynthesis
- Pharmacological Effects of Natural Compounds
- Fatty Acid Research and Health
- Cholesterol and Lipid Metabolism
- Polysaccharides and Plant Cell Walls
Pudong Medical Center
2021-2025
Fudan University
2021-2025
Fifth Affiliated Hospital of Zhengzhou University
2025
Shanxi Medical University
2025
Southwest Minzu University
2021-2025
Chongqing Medical and Pharmaceutical College
2024
Jiangsu University
2018-2023
Affiliated Hospital of Jiangsu University
2018-2023
Chengdu University of Traditional Chinese Medicine
2023
Chongqing Medical University
2010-2022
The kidney not only regulates fluid and electrolyte balance but also functions as an endocrine organ. For instance, it is the major source of circulating erythropoietin renin. Despite currently available therapies, there a marked increase in cardiovascular morbidity mortality among patients suffering from end-stage renal disease. We hypothesized that current understanding function was incomplete organ might secrete additional proteins with important biological roles. Here we report...
We previously identified renalase, a secreted novel amine oxidase that specifically degrades circulating catecholamines. Parenteral administration of either native or recombinant renalase lowers blood pressure, heart rate, and cardiac contractility by metabolizing Renalase plasma levels are markedly reduced in patients with chronic kidney disease. It is not known whether endogenous contributes to the regulation catecholamines.We show here lacks significant activity under basal conditions...
Abstract Central nervous system (CNS) diseases are the leading cause of morbidity and mortality; their treatment, however, remains constrained by blood–brain barrier (BBB) that impedes access most therapeutics to brain. A CNS delivery platform for protein therapeutics, which is achieved encapsulating proteins within nanocapsules contain choline acetylcholine analogues, reported herein. Mediated nicotinic receptors transporters, such can effectively penetrate BBB deliver CNS, as demonstrated...
Voltage-gated potassium (Kv) channels regulate cell membrane potential and control a variety of cellular processes. Kv1.3 are expressed in several tissues believed to participate volume regulation, apoptosis, T activation renal solute homeostasis. Examination Kv1.3-deficient mice (Kv1.3(-/-)), generated by gene targeting, revealed previously unrecognized role for body weight regulation. Indeed, Kv1.3(-/-) weigh significantly less than littermates. Moreover, knockout protected from...
Kv1.3 is a voltage-gated potassium (K) channel expressed in number of tissues, including fat and skeletal muscle. Channel inhibition improves experimental autoimmune encephalitis, part by reducing IL-2 tumor necrosis factor production peripheral T lymphocytes. Gene inactivation causes mice (Kv1.3-/-) exposed to high-fat diet gain less weight be obese than littermate control. Interestingly, although Kv1.3-/- on the high-calorie weight, they remain euglycemic, with low blood insulin levels....
Previous studies confirmed that dietary supplements of fish oil and krill can alleviate obesity in mice, but the underlying mechanism remains unclear. This study aims to discern whether treatment change structure gut microbiota during alleviation. The ICR mice received high-fat diet (HFD) continuously for 12 weeks after two acclimatization with a standard chow diet, fed were used as control. In groups HFD supplementation, weight gains attenuated liver index, total cholesterol, triglyceride...
Direct Observation of Procedural Skills (DOPS) is a clinical assessment tool that enables trainers to observe medical students' procedural abilities in real-time settings. It assesses knowledge application, decision-making, and skill proficiency during tasks. This study modifies the DOPS evaluate operation insulin pumps (PUMP) continuous glucose monitoring systems (CGMS) diabetes management. Key elements modified include 1) Knowledge Assessment: Evaluating understanding PUMP CGMS, including...
Intramuscular fat (IMF), or marbling, is a critical indicator of goat meat quality. Non-coding RNAs play key role in the formation and deposition IMF vertebrates by regulating genes involved its synthesis, degradation, transport. The competing endogenous RNA (ceRNA) hypothesis identifies circular (circRNAs) as natural "sponges" for microRNAs (miRNAs). However, precise mechanisms circRNAs remain poorly understood. In current study, we utilized existing sequencing data to construct ceRNA...
ABSTRACT Background Bipolar disorder (BD) is a complex mental condition of which the mechanism onset remains unclear. Mendelian randomization (MR) allows evaluation causal effects biomarkers by minimizing risks reverse causation and confounding factors. In this study, MR was used to assess relationships between neurodevelopment‐related proteins BD, thereby providing potential evidence for neurodevelopmental hypothesis disorder. Methods Leveraging data from large‐scale genome‐wide association...
Kv1.3 is a voltage-gated K + channel expressed in insulin-sensitive tissues. We previously showed that gene inactivation or pharmacological inhibition of activity increased peripheral insulin sensitivity independently body weight by augmenting the amount GLUT4 at plasma membrane. In present study, we further examined effect on trafficking and tested whether it occurred via an insulin-dependent pathway. found margatoxin (MgTX) stimulated glucose uptake adipose tissue skeletal muscle MgTX...
Abstract In this study, we characterized the functional role of long noncoding RNA (lncRNA), brain derived neurotrophic factor anti‐sense (BDNF‐AS) in regulating D‐glucose‐induced (DGI) apoptosis human retinal pigment epithelial (RPE) cells. Human RPE cell line, ARPE‐19 cells were cultured vitro and treated with various concentrations D‐glucose for 24 h. A TUNEL assay was applied immunohistochemical quantitative approaches to assess apoptotic effect D‐glucose. Under condition 50 mM...
To investigate the effect of baicalin on reactive oxygen species (ROS)/ NOD-like receptor protein 3 (NLRP3)/Caspase-1/gasdermin-D (GSDMD) inflammasome pathway and its related mechanism in regulating pyroptosis human renal tubular epithelial cells (HK-2) induced by contrast media.Iohexol was used to act HK-2 establish a cell model; signal genes were silenced, cytokines detected enzyme-linked immunosorbent assay (ELISA), viability, gene expression, expression evaluated double fluorescence...
Glutamine:fructose-6-phosphate amidotransferase (Gfat) catalyzes the first and rate-limiting step in hexosamine biosynthetic pathway. The increasing amount of evidence that links excess biosynthesis with pathogenic complications type II diabetes highlights need to understand regulation Gfat. Previous studies showed eukaryotic Gfat is subjected feedback inhibition by UDP-N-acetyl-d-glucosamine (UDP-GlcNAc) phosphorylation cAMP-activated protein kinase A (PKA). In this study, overexpression...
Abstract Background Lipid metabolism imbalance has been recognized as one of the major drivers impaired glucose in context type 2 diabetes mellitus (T2DM), rates which are steadily increasing worldwide. Impaired regulation (IGR) plays a vital role prevention and treatment T2DM. The goal this study was to further clarify whether combination plant sterols (PS) omega-3 fatty acids yields any synergistic effect that enhances IGR. Methods A total 200 participants were randomized receive PS ( n =...
We detected whether serum asprosin levels play a role in the occurrence and development of albuminuria patients with type 2 diabetes mellitus (T2DM), which has not been previously discussed.Based on urinary albumin/creatinine ratio (UACR), 207 T2DM were divided into normoalbuminuria (UACR<30 mg/g), microalbuminuria (30≤UACR<300 macroalbuminuria (UACR≥300 mg/g). Serum determined by enzyme-linked immunosorbent assay.Comparatively, patient groups [2.37 (1.63-3.57)] [2.10 (1.60-2.90)]...
The aim of the present study was to examine effects 3,5,4'-tri-O-acetylresveratrol on connexin 43 (Cx43) in acute lung injury (ALI) rats induced by tracheal instillation artificial seawater. Different doses (50, 150, and 450 mg/kg) were administered orally for 7 days before modeling. Four hours after seawater inhalation, histological changes, contents TNF- α , IL-1 β IL-10, expression Cx43 lungs detected. Besides, gap junction communication A549 cells human umbilical vein endothelial...
The therapeutic application of small interfering RNA (siRNA) requires safe nanocarriers for specific and efficient delivery in vivo. Herein, PEGylated cationic cerasomes (PCCs) were fabricated by doping a lipid with hydroxyl group into nanohybrid cerasomes. Multiple properties PCCs provide solution to many the limitations associated current platforms siRNA. polyorganosiloxane surface imparts higher morphological stability than conventional liposomes. PEGylation cerasome could protect...
Betatrophin is a widely used diagnostic marker for type 2 diabetes mellitus (DM), but its clinical utility in diagnosing gestational DM (GDM) unclear. We evaluated the relationship between betatrophin and risk of GDM as well ability to predict postpartum (PDM).In total, 386 patients were categorized into those with without PDM. All underwent oral glucose tolerance test while pregnant. was assessed examine characteristics GDM.The concentration remarkably higher than GDM. The three groups; 300...
Objective: Tsukushi is a newly identified hepatokine. Recent studies have shown that it relates to diabetes, lipid metabolism and fibrosis, but there currently no investigation about whether associated with diabetic kidney disease. Therefore, this study aimed investigate the relationship between disease by characterizing levels in healthy subjects type 2 diabetes urinary albumin-creatinine ratio. Methods: Serum level was quantified enzyme-linked immunosorbent assay 167 normoalbuminuria, 80...