A5090991475- Quinazolinone synthesis and applications
- Synthesis and biological activity
- Alcohol Consumption and Health Effects
- Sodium Intake and Health
- Heme Oxygenase-1 and Carbon Monoxide
- Nutritional Studies and Diet
- Cancer therapeutics and mechanisms
- Trace Elements in Health
- Neuropeptides and Animal Physiology
- Iron Metabolism and Disorders
- Consumer Attitudes and Food Labeling
- Adipose Tissue and Metabolism
- Liver Disease Diagnosis and Treatment
- Biochemical effects in animals
- Chemical Synthesis and Analysis
- Ferroptosis and cancer prognosis
- Retinoids in leukemia and cellular processes
- Synthesis and Biological Evaluation
- Advanced Glycation End Products research
- Exercise and Physiological Responses
- Autophagy in Disease and Therapy
- Fatty Acid Research and Health
- Cannabis and Cannabinoid Research
- Food composition and properties
- Diet, Metabolism, and Disease
Chinese Center For Disease Control and Prevention
2016-2025
Capital Medical University
2024
National Health and Family Planning Commission
2020-2024
Zhengzhou University
2021-2023
Jiangxi University of Traditional Chinese Medicine
2023
Peking University Shenzhen Hospital
2023
Eye & ENT Hospital of Fudan University
2020
Huazhong University of Science and Technology
2011-2016
Ministry of Ecology and Environment
2014-2016
Chinese Research Academy of Environmental Sciences
2016
(1) Background: Pancreatic iron deposition has been found in the progression of type 2 diabetes (T2DM); however, whether ferroptosis contributes to dysfunction pancreatic β cells (PBC) remains enigmatic. Moreover, potential protective effect quercetin is also elusive; (2) Methods: T2DM mice model was established by multiple low dose streptozocin (STZ) injection, after which intervened for 4 months; (3) Results: Substantially normalized glucose tolerance, diabetic symptoms, homeostasis...
Cancer cells and ischemic diseases exhibit unique metabolic responses adaptations to energy stress. Forkhead box O 3a (FoxO3a) is a transcription factor that plays an important role in cell metabolism, mitochondrial dysfunction oxidative stress response. Although the AMP-activated protein kinase (AMPK)/FoxO3a signaling pathway pivotal maintaining homeostasis under conditions of stress, AMPK/FoxO3a mitochondria-associated ferroptosis has not yet been fully elucidated. We show glucose...
A growing body of evidence has indicated that high-fat diet-induced nonalcoholic fatty liver disease is usually accompanied by oxidized low-density lipoprotein (ox-LDL) deposited in the liver. The current study aimed to investigate effect quercetin on ox-LDL accumulation and explore potential underlying mechanisms. results demonstrate supplementation for 24 weeks significantly alleviated damage reduced hepatic cholesterol level. Quercetin notably inhibited both mRNA protein expression CD36...
Quercetin has multiple protective effects against cardiometabolic diseases, but the biological mechanisms underlying benefits in diabetic cardiomyopathy (DCM) are unclear. A mouse DCM model was established by high-fat diet (HFD, 8 months) combined with streptozotocin injection (at mid-feeding), and quercetin (100 mg per kg day) administrated orally after streptozotocin. Our major results indicated that cardiac ejection fraction fractional shortening, mRNA levels of Collagen I CTGF, protein...
The mechanisms underlying intense exercise‐induced liver damage and its potential treatments remain unclear. We explored the hepatoprotection of quercetin, a naturally occurring flavonoid, in strenuous exercise‐derived endoplasmic reticulum stress (ERS) inflammation. Intense exercise (28 m/min at 5° slope for 90 min) resulted leakage aminotransferases BALB/C mice. hepatic ultrastructural malformations oxidative levels were attenuated by quercetin (100 mg/kg·bw). thapsigargin‐ (Tg‐) induced...
Microglial HO-1 regulates iron metabolism in the brain. Intracerebral haemorrhage (ICH) shares features of ferroptosis and necroptosis; hemin is an oxidized product haemoglobin from lysed red blood cells, leading to secondary injury. However, little known about underlying molecular mechanisms attributable injury by or ICH. In this study, we first show that FoxO3a was highly co-located with neurons microglia but not astrocytes area ICH model mice. Hemin activated FoxO3a/ATG-mediated autophagy...
The legality of the assignment future receivables in Chinese law has undergone a significant transformation, representing another instance continuously updating itself to meet transactional demands. does not recognize independent juristic act real rights, thus offering more flexible legal framework for explaining receivables. To eliminate negative externalities receivables, it is essential refine certainty standard exclude assignments that lack any determinability and establish unified...
Interleukin 33 (IL33) drives liver fibrosis, and individuals with type 2 diabetes mellitus are more likely advanced to fibrosis. However, the role of IL33 in diabetic fibrosis remains unclear, prompting our investigation. We developed a model wild-type, IL33-/-, suppression tumorigenicity (ST2-/-, receptor) mice. Furthermore, wild-type mice were injected neutralizing antibody (αIL33). also co-cultured human endothelial cells hepatic stellate identify high palmitic acid glucose conditions....
Summary Studies on turnover intention among Chinese general practitioners (GPs) at the national level are limited. This study aimed to assess leave and its associated factors a nationally representative sample of GPs. The participants were selected using multistage stratified random sampling method. A self‐administered structured questionnaire was used collect data from 3236 GPs in China between October 2017 February 2018. multiple linear stepwise regression analysis identify with intention....
Abstract Objectives Senescence, characterized by permanent cycle arrest, plays an important role in diabetic nephropathy (DN). However, the mechanism of renal senescence is still unclear, and treatment targeting it remains to be further explored. Materials Methods The DN mice were induced HFD STZ, 3 types cells treated with high glucose (HG) establish vitro model. Senescence‐related autophagy‐related markers detected qRT‐PCR Western blot. Further, autophagy inhibitors co‐immunoprecipitation...
Accumulated senescent cells during the aging process are a key driver of functional decline and age-related disorders. Here, we identify ganoderic acid A (GAA) as potent anti-senescent compound with low toxicity favorable drug properties through high-content screening. GAA, major natural component Ganoderma lucidum, possesses broad-spectrum geroprotective activity across various species. In C. elegans, GAA treatment extends lifespan healthspan effectively rapamycin. Administration also...